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CSH2 chorionic somatomammotropin hormone 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281097, updated on 12-Oct-2024

Summary

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Gene symbol
CSH2
Gene description
chorionic somatomammotropin hormone 2
See related
Ensembl:ENSBTAG00000006761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PL; PL1; CSH1
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Genomic context

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See CSH2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (35287200..35299843)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene placental prolactin-related protein 3-like Neighboring gene chorionic somatomammotropin hormone 1-like Neighboring gene prolactin Neighboring gene HDGF like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The characterization of DNA methylation-mediated regulation of bovine placental lactogen and bovine prolactin-related protein-1 genes. Nakaya Y, et al. BMC Mol Biol, 2009 Mar 5. PMID 19261194, Free PMC Article
  2. Bovine placental lactogen: molecular cloning and protein structure. Schuler LA, et al. Biochemistry, 1988 Nov 1. PMID 3242594
  3. Structure of the bovine placental lactogen gene and alternative splicing of transcripts. Kessler MA, et al. DNA Cell Biol, 1991 Mar. PMID 2003877
  4. Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies. Ravelich SR, et al. Biol Reprod, 2004 Dec. PMID 15306554
  5. Expression of new members of the prolactin growth hormone gene family in bovine placenta. Isolation and characterization of two prolactin-like cDNA clones. Yamakawa M, et al. J Biol Chem, 1990 May 25. PMID 2341410

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This is the first report to identify the differential regulatory mechanisms of the bCSH1 and bPRP1 genes and indicates that bCSH1 might potentially be the only transcript that is subject to DNA methyltransferase regulation.
    Title: The characterization of DNA methylation-mediated regulation of bovine placental lactogen and bovine prolactin-related protein-1 genes.
  2. Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
    Title: Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymes.
  3. Dysregulation of PL and leptin in nuclear transfer placentomes could affect cell migration and invasion and subsequently placental metabolism and transfer of nutrients to fetus, leading to increased placental and fetal macrosomia.
    Title: Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables prolactin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mammary gland development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of lactation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
chorionic somatomammotropin hormone 2
Names
BPLP-I
BPLP-II
chorionic somatomammotropin hormone 1 (placental lactogen)
placental lactogen I
placental lactogen II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164321.1 → NP_001157793.1  chorionic somatomammotropin hormone 2 isoform 2

    See identical proteins and their annotated locations for NP_001157793.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to variant 1.
    Source sequence(s)
    BC149388, CX736016, EE252986
    UniProtKB/TrEMBL
    A0AAA9TSX5, A6QPM4
    Related
    ENSBTAP00000100447.1, ENSBTAT00000112534.1
    Conserved Domains (1) summary
    cd10288
    Location:80 → 237
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. NM_181007.2 → NP_851350.2  chorionic somatomammotropin hormone 2 isoform 1

    See identical proteins and their annotated locations for NP_851350.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC149388, CX736016, EE252986, EV793172
    UniProtKB/Swiss-Prot
    P09611
    UniProtKB/TrEMBL
    F1MYF0
    Related
    ENSBTAP00000035394.6, ENSBTAT00000035519.6
    Conserved Domains (1) summary
    cd10288
    Location:80 → 273
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    35287200..35299843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059880204.1 → XP_059736187.1  chorionic somatomammotropin hormone 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09611.2 GenPept UniProtKB/Swiss-Prot:P09611
P19159.1 GenPept UniProtKB/Swiss-Prot:P19159

Gene LinkOut

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