LEP leptin [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LEPprovided by VGNC
Official Full Name: leptinprovided by VGNC
Primary source: VGNC:VGNC:30842
See related: BGD:BT11292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ob
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (92436910..92453660)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows.
Title: LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows.
Single nucleotide polymorphisms of leptin gene in five Ethiopian indigenous cattle breeds and the Korean Hanwoo breed.
Title: Single nucleotide polymorphisms of leptin gene in five Ethiopian indigenous cattle breeds and the Korean Hanwoo breed.
Consistent with this, leptin enhanced GnRH-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
Title: Leptin regulation of inward membrane currents, electrical activity and LH release in isolated bovine gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
Title: Impacts of a leptin SNP on growth performance and carcass characters in finishing steers studied over time.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
Title: Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Title: Leptin concentrations in finishing beef steers and heifers and their association with dry matter intake, average daily gain, feed efficiency, and body composition.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Title: Relationship of leptin concentrations with feed intake, growth, and efficiency in finishing beef steers.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
Title: Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle.
Leptin R25C genotype impacted most traits associated with fatness.
Title: Impact of a leptin single nucleotide polymorphism and ractopamine hydrochloride on growth and carcass characteristics in finishing steers.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Title: [LEP gene allelic polymorphism in a subpopulation of Ayrshire cattle].

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General gene information

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Markers

BM1501 (e-PCR), detects polymorphism
- UniSTS:251489

BM1500 (e-PCR), detects polymorphism
- UniSTS:45985

LEP-2 (e-PCR)
- UniSTS:253876

LEP-3 (e-PCR)
- UniSTS:253879

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase C activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in energy reserve metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to insulin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leptin

Names: obese; obesity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.