Gphn gephyrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gphnprovided by MGI
Official Full Name: gephyrinprovided by MGI
Primary source: MGI:MGI:109602
See related: Ensembl:ENSMUSG00000047454 AllianceGenome:MGI:109602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPH; geph; GPHRYN; C230040D23; 5730552E08Rik
Summary: Enables molybdopterin molybdotransferase activity. Involved in molybdopterin cofactor biosynthetic process and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within Mo-molybdopterin cofactor biosynthetic process and synapse organization. Located in several cellular components, including inhibitory synapse; postsynaptic density; and synaptic membrane. Is active in GABA-ergic synapse and postsynaptic specialization, intracellular component. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 8.6), CNS E18 (RPKM 8.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 35.51 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (78264099..78731546)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (78217325..78684772)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants.
Title: Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants.
Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density.
Title: Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABA(A)R density.
Study unravels the critical role for cellular signal transduction pathways in determining gephyrin SUMOylation, phosphorylation and acetylation at identified residues to regulate its scaffolding properties at specific postsynaptic sites and in turn regulating GABAergic function and plasticity.
Title: Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Ablation of gephyrin result in the forebrain-specific loss of postsynaptic gamma2-GABAA receptors, reduces LTP and network excitability in the dentate gyrus.
Title: Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.
Title: Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus.
The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/
Title: Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Data suggest that KIF5 regulates gephyrin sorting by a mechanism that involves GSK3 activity.
Title: GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.
Pin1-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2/gephyrin interaction.
Title: Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.
These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII-dependent phosphorylation site on gephyrin.
Title: Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses
Title: Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gphn (e-PCR), detects polymorphism
- UniSTS:536577

13.MMHAP76FRE7.seq (e-PCR)
- UniSTS:123183

NoName (e-PCR)
- UniSTS:236880

AI662856 (e-PCR)
- UniSTS:185937

NoName (e-PCR)
- UniSTS:236889

MARC_1069-1070:991929832:1 (e-PCR)
- UniSTS:230842

BB167507 (e-PCR)
- UniSTS:208828

mHAa21f6.seq (e-PCR)
- UniSTS:125950

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molybdopterin adenylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin molybdotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin molybdotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables molybdopterin molybdotransferase activity	ISO Inferred from Sequence Orthology more info
enables nitrate reductase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of synaptic specificity at neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of synaptic specificity at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gamma-aminobutyric acid receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molybdopterin cofactor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in molybdopterin cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to metal ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gephyrin

NP_666077.2

EC 2.10.1.1

EC 2.7.7.75

NP_766540.2

EC 2.10.1.1

EC 2.7.7.75

XP_006515962.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515963.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515964.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515965.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515966.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515967.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515968.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515969.1

EC 2.10.1.1

EC 2.7.7.75

XP_006515970.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170562.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170563.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170564.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170565.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170566.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170567.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170568.1

EC 2.10.1.1

EC 2.7.7.75

XP_017170569.1

EC 2.10.1.1

EC 2.7.7.75

XP_030102590.1

EC 2.10.1.1

EC 2.7.7.75

XP_030102591.1

EC 2.10.1.1

EC 2.7.7.75

XP_030102592.1

EC 2.10.1.1

EC 2.7.7.75

XP_030102593.1

EC 2.10.1.1

EC 2.7.7.75

XP_036013318.1

EC 2.10.1.1

EC 2.7.7.75

XP_036013319.1

EC 2.10.1.1

EC 2.7.7.75

XP_036013321.1

EC 2.10.1.1

EC 2.7.7.75

XP_036013322.1

EC 2.10.1.1

EC 2.7.7.75

XP_036013323.1

EC 2.10.1.1

EC 2.7.7.75

XP_036013324.1

EC 2.10.1.1

EC 2.7.7.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145965.2 → NP_666077.2 gephyrin isoform 1

See identical proteins and their annotated locations for NP_666077.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC148324, BC127058, CO043793

Consensus CDS

CCDS49095.1

UniProtKB/TrEMBL

A0JNY3

Related

ENSMUSP00000106018.3, ENSMUST00000110388.10

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:363 → 769

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
NM_172952.3 → NP_766540.2 gephyrin isoform 2

See identical proteins and their annotated locations for NP_766540.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks one coding exon and contains two additional coding exons compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC125057, AC132097, AC148324, AK082353, CO043793

Consensus CDS

CCDS26000.1

UniProtKB/Swiss-Prot

E9QKJ1, Q8BUV3

Related

ENSMUSP00000054064.5, ENSMUST00000052472.6

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:360 → 766

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

78264099..78731546

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515899.4 → XP_006515962.1 gephyrin isoform X7

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:417 → 823

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315079.3 → XP_017170568.1 gephyrin isoform X20

Conserved Domains (2) summary

cd00886
Location:15 → 163

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:303 → 709

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515903.5 → XP_006515966.1 gephyrin isoform X6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:394 → 800

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_036157425.1 → XP_036013318.1 gephyrin isoform X10

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:380 → 786

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_030246732.2 → XP_030102592.1 gephyrin isoform X22

Conserved Domains (2) summary

cd00886
Location:15 → 163

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:270 → 676

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_036157428.1 → XP_036013321.1 gephyrin isoform X21

Conserved Domains (2) summary

cd00886
Location:15 → 150

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:290 → 696

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515901.5 → XP_006515964.1 gephyrin isoform X1

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:430 → 836

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_036157431.1 → XP_036013324.1 gephyrin isoform X27

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:371 → 777

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515900.5 → XP_006515963.1 gephyrin isoform X2

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:416 → 822

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315073.3 → XP_017170562.1 gephyrin isoform X3

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:411 → 817

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315077.3 → XP_017170566.1 gephyrin isoform X15

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:359 → 765

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_030246730.2 → XP_030102590.1 gephyrin isoform X14

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:361 → 767

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_036157430.1 → XP_036013323.1 gephyrin isoform X24

Conserved Domains (2) summary

cd00886
Location:15 → 163

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:249 → 655

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515904.5 → XP_006515967.1 gephyrin isoform X9

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:381 → 787

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_036157426.1 → XP_036013319.1 gephyrin isoform X12

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:367 → 773

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315076.3 → XP_017170565.1 gephyrin isoform X13

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:362 → 768

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_036157429.1 → XP_036013322.1 gephyrin isoform X23

Conserved Domains (2) summary

cd00886
Location:15 → 150

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:257 → 663

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515902.5 → XP_006515965.1 gephyrin isoform X5

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:395 → 801

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315074.3 → XP_017170563.1 gephyrin isoform X4

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:397 → 803

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515906.5 → XP_006515969.1 gephyrin isoform X18

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:340 → 746

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315078.3 → XP_017170567.1 gephyrin isoform X17

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:346 → 752

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_030246731.2 → XP_030102591.1 gephyrin isoform X16

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:348 → 754

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_030246733.2 → XP_030102593.1 gephyrin isoform X25

Conserved Domains (2) summary

cd00886
Location:15 → 150

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:236 → 642

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515905.5 → XP_006515968.1 gephyrin isoform X11

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:376 → 782

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315075.3 → XP_017170564.1 gephyrin isoform X8

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:382 → 788

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_006515907.5 → XP_006515970.1 gephyrin isoform X19

See identical proteins and their annotated locations for XP_006515970.1

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:327 → 733

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_017315080.3 → XP_017170569.1 gephyrin isoform X26

Conserved Domains (1) summary

cd00887
Location:10 → 416

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...