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Bahcc1 BAH domain and coiled-coil containing 1 [ Mus musculus (house mouse) ]

Gene ID: 268515, updated on 10-Jun-2024

Summary

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Official Symbol
Bahcc1provided by MGI
Official Full Name
BAH domain and coiled-coil containing 1provided by MGI
Primary source
MGI:MGI:2679272
See related
Ensembl:ENSMUSG00000039741 AllianceGenome:MGI:2679272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930044J06
Summary
Predicted to enable chromatin binding activity. Is expressed in central nervous system and retina. Orthologous to human BAHCC1 (BAH domain and coiled-coil containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.0), CNS E14 (RPKM 5.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Bahcc1 in Genome Data Viewer
Location:
11 E2; 11 83.96 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120123696..120183123)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120232870..120292297)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11770 Neighboring gene RIKEN cDNA 2900052L18 gene Neighboring gene STARR-seq mESC enhancer starr_31347 Neighboring gene predicted gene 11772 Neighboring gene STARR-seq mESC enhancer starr_31350 Neighboring gene STARR-positive B cell enhancer ABC_E3044 Neighboring gene STARR-positive B cell enhancer ABC_E9383 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120172126-120172235 Neighboring gene VISTA enhancer mm1481 Neighboring gene RIKEN cDNA 0610009L18 gene Neighboring gene microRNA 6935 Neighboring gene actin, gamma, cytoplasmic 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Fan H, et al. Nat Genet, 2020 Dec. PMID 33139953, Free PMC Article
  2. Regulation of neuronal commitment in mouse embryonic stem cells by the Reno1/Bahcc1 locus. Hezroni H, et al. EMBO Rep, 2020 Nov 5. PMID 32969152, Free PMC Article
  3. A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. Nakayama M, et al. FASEB J, 2006 Aug. PMID 16807365
  4. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia.
    Title: Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia.
  2. Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression.
    Title: Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • KIAA1447, MGC79150

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
BAH and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347621.2 → NP_001334550.1  BAH and coiled-coil domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AL928567
    Consensus CDS
    CCDS83943.1
    UniProtKB/Swiss-Prot
    A2AS78, Q0KK52, Q0KK57, Q3TPP4, Q3UHG9, Q3UHR0, Q6GQV4, Q6P9S8, Q6PFC9, Q80UX2
    Related
    ENSMUSP00000112827.2, ENSMUST00000122148.8
    Conserved Domains (2) summary
    cd04714
    Location:2516 → 2635
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cl07283
    Location:1984 → 2036
    Tudor_3; DNA repair protein Crb2 Tudor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120123696..120183123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249048.3 → XP_011247350.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011247350.1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  2. XM_017314567.2 → XP_017170056.1  BAH and coiled-coil domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2636
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cl07283
    Location:1985 → 2037
    Tudor_3; DNA repair protein Crb2 Tudor domain

  3. XM_017314566.2 → XP_017170055.1  BAH and coiled-coil domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd04714
    Location:2516 → 2679
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cl07283
    Location:1984 → 2036
    Tudor_3; DNA repair protein Crb2 Tudor domain

  4. XM_036156725.1 → XP_036012618.1  BAH and coiled-coil domain-containing protein 1 isoform X5

  5. XM_030246038.1 → XP_030101898.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  6. XM_011249053.3 → XP_011247355.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011247355.1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  7. XM_011249051.2 → XP_011247353.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011247353.1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  8. XM_036156723.1 → XP_036012616.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  9. XM_011249054.4 → XP_011247356.1  BAH and coiled-coil domain-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011247356.1

    UniProtKB/Swiss-Prot
    A2AS78, Q0KK52, Q0KK57, Q3TPP4, Q3UHG9, Q3UHR0, Q6GQV4, Q6P9S8, Q6PFC9, Q80UX2
    Related
    ENSMUSP00000112784.2, ENSMUST00000118987.2
    Conserved Domains (2) summary
    cd04714
    Location:2516 → 2635
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cl07283
    Location:1984 → 2036
    Tudor_3; DNA repair protein Crb2 Tudor domain

  10. XM_011249049.4 → XP_011247351.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011247351.1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  11. XM_011249050.4 → XP_011247352.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011247352.1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

  12. XM_011249052.4 → XP_011247354.1  BAH and coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011247354.1

    Conserved Domains (2) summary
    cd04714
    Location:2517 → 2680
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20470
    Location:1975 → 2042
    Tudor_BAHCC1; Tudor domain found in BAH and coiled-coil domain-containing protein 1 (BAHCC1) and similar proteins

RNA

  1. XR_001780012.2 RNA Sequence

  2. XR_003949454.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198423.4: Suppressed sequence

    Description
    NM_198423.4: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHR0.2 GenPept UniProtKB/Swiss-Prot:Q3UHR0

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