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Mnat1 MNAT1 component of CDK activating kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 266713, updated on 14-Nov-2024

Summary

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Official Symbol
Mnat1provided by RGD
Official Full Name
MNAT1 component of CDK activating kinaseprovided by RGD
Primary source
RGD:628874
See related
EnsemblRapid:ENSRNOG00000007267 AllianceGenome:RGD:628874
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and metal ion binding activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of apoptotic process; and positive regulation of smooth muscle cell proliferation. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of CAK-ERCC2 complex; RNA polymerase II transcription regulator complex; and cyclin-dependent protein kinase holoenzyme complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 166.7), Thymus (RPKM 116.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mnat1 in Genome Data Viewer
Location:
6q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (97550566..97706598)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (91814703..91971945)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (95995341..96153331)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351257 Neighboring gene SIX homeobox 1 Neighboring gene SIX homeobox 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 1 Neighboring gene tRNA methyltransferase 5 Neighboring gene solute carrier family 38, member 6 Neighboring gene ribosomal protein L26, pseudogene 13 Neighboring gene ribosomal protein L26, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells. Wu L, et al. J Biol Chem, 1999 Feb 26. PMID 10026172
  2. CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes. Fujii W, et al. Biol Reprod, 2011 Dec. PMID 21778139
  3. Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. Busso D, et al. J Biol Chem, 2000 Jul 28. PMID 10801852
  4. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
  5. A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH. Sandrock B, et al. J Biol Chem, 2001 Sep 21. PMID 11445587

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adult heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CAK-ERCC2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in germinal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIK complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CDK-activating kinase assembly factor MAT1
Names
MNAT CDK-activating kinase assembly factor 1
MNAT1, CDK activating kinase assembly factor
menage a trois 1
menage a trois homolog 1, cyclin H assembly factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153472.2 → NP_703202.1  CDK-activating kinase assembly factor MAT1

    See identical proteins and their annotated locations for NP_703202.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078712
    UniProtKB/TrEMBL
    A0A8I5ZYY1, A6HC54, Q6AZ68, Q8CIR5
    Conserved Domains (1) summary
    TIGR00570
    Location:1 → 308
    cdk7; CDK-activating kinase assembly factor MAT1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    97550566..97706598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261569.1 → XP_063117639.1  CDK-activating kinase assembly factor MAT1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV40

  2. XM_063261570.1 → XP_063117640.1  CDK-activating kinase assembly factor MAT1 isoform X2

    UniProtKB/TrEMBL
    F7EX11
    Related
    ENSRNOP00000010163.4, ENSRNOT00000010163.7
Nucleotide Protein Strain
Heading Accession and Version

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