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ZBTB20 zinc finger and BTB domain containing 20 [ Homo sapiens (human) ]

Gene ID: 26137, updated on 2-Nov-2024

Summary

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Official Symbol
ZBTB20provided by HGNC
Official Full Name
zinc finger and BTB domain containing 20provided by HGNC
Primary source
HGNC:HGNC:13503
See related
Ensembl:ENSG00000181722 MIM:606025; AllianceGenome:HGNC:13503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOF; DPZF; PRIMS; ODA-8S; ZNF288
Summary
This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Expression
Ubiquitous expression in kidney (RPKM 4.0), ovary (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZBTB20 in Genome Data Viewer
Location:
3q13.31
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (114314500..115147288, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (117035293..117867765, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (114033347..114866135, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:114017997-114018498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:114018499-114018998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20274 Neighboring gene uncharacterized LOC124909411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20275 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:114074859-114075500 Neighboring gene ZBTB20 antisense RNA 1 Neighboring gene T cell immunoreceptor with Ig and ITIM domains Neighboring gene microRNA 568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20277 Neighboring gene ZBTB20 antisense RNA 5 Neighboring gene VISTA enhancer hs253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20278 Neighboring gene microRNA 4796 Neighboring gene ZBTB20 antisense RNA 3 Neighboring gene Y-box binding protein 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20279 Neighboring gene ZBTB20 antisense RNA 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20284 Neighboring gene VISTA enhancer hs1648 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:114958135-114959334 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:115003756-115004955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:115036984-115037582 Neighboring gene eukaryotic translation initiation factor 4E family member 2 pseudogene 2 Neighboring gene uncharacterized LOC105374051

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assessment of the association between ZBTB20 rs9841504 polymorphism and gastric and esophageal cancer susceptibility: a meta-analysis. Shi J, et al. Int J Biol Markers, 2017 Mar 2. PMID 27646774
  2. HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma. He Z, et al. Mol Med Rep, 2020 Jul. PMID 32319639, Free PMC Article
  3. Primrose syndrome: Characterization of the phenotype in 42 patients. Melis D, et al. Clin Genet, 2020 Jun. PMID 32266967, Free PMC Article
  4. Primrose syndrome: a phenotypic comparison of patients with a ZBTB20 missense variant versus a 3q13.31 microdeletion including ZBTB20. Juven A, et al. Eur J Hum Genet, 2020 Aug. PMID 32071410, Free PMC Article
  5. Primrose syndrome associated with unclassified immunodeficiency and a novel ZBTB20 mutation. Yamamoto-Shimojima K, et al. Am J Med Genet A, 2020 Mar. PMID 31821719

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Le miR-224-5p regule sert de biomarqueur pour l'insuffisance hepatique aigue pediatrique et regule l'inflammation en modulant ZBTB20].
    Title: [Le miR-224-5p régulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20].
  2. Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player in Pathogenesis and Development of Human Cancers.
    Title: Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player in Pathogenesis and Development of Human Cancers.
  3. Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications.
    Title: Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications.
  4. Circ_0001602 aggravates the progression of acute myeloid leukemia by regulating the miR-192-5p/ZBTB20 axis.
    Title: Circ_0001602 aggravates the progression of acute myeloid leukemia by regulating the miR-192-5p/ZBTB20 axis.
  5. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
    Title: The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
  6. Spatial control of astrogenesis progression by cortical arealization genes.
    Title: Spatial control of astrogenesis progression by cortical arealization genes.
  7. Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.
    Title: Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.
  8. An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20.
    Title: An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20.
  9. LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis.
    Title: LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis.
  10. Primrose syndrome: Characterization of the phenotype in 42 patients.
    Title: Primrose syndrome: Characterization of the phenotype in 42 patients.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Primrose syndrome
MedGen: C0796121 OMIM: 259050 GeneReviews: Primrose Syndrome
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
EBI GWAS Catalog
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13240, FLJ26458, DKFZp566F123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 20
Names
BTB/POZ zinc finger protein DPZF
dendritic cell-derived BTB/POZ zinc finger
zinc finger protein 288

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052992.1 RefSeqGene

    Range
    4993..837781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164342.2 → NP_001157814.1  zinc finger and BTB domain-containing protein 20 isoform 1

    See identical proteins and their annotated locations for NP_001157814.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC093010, AC131152, AF139460, BC090936, BG993862
    Consensus CDS
    CCDS54626.1
    UniProtKB/Swiss-Prot
    Q63HP6, Q8N6R5, Q9HC78, Q9Y410
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:352 → 442
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:580 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:378 → 571
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18208
    Location:79 → 195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634 → 656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648 → 673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608 → 657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  2. NM_001164343.2 → NP_001157815.1  zinc finger and BTB domain-containing protein 20 isoform 2

    See identical proteins and their annotated locations for NP_001157815.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093010, AC131152, BC090936, BF327758
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000420324.1, ENST00000462705.5
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  3. NM_001164344.4 → NP_001157816.1  zinc finger and BTB domain-containing protein 20 isoform 2

    See identical proteins and their annotated locations for NP_001157816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093010, AC131152, AL050276, DB131355
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000417307.1, ENST00000464560.5
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  4. NM_001164345.4 → NP_001157817.1  zinc finger and BTB domain-containing protein 20 isoform 2

    See identical proteins and their annotated locations for NP_001157817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093010, AC131152, AK225788, BC090936
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000419902.1, ENST00000471418.5
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  5. NM_001164346.2 → NP_001157818.1  zinc finger and BTB domain-containing protein 20 isoform 2

    See identical proteins and their annotated locations for NP_001157818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093010, AC131152, AK315307, BC090936, DB268190
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000420684.2, ENST00000470311.6
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  6. NM_001164347.2 → NP_001157819.1  zinc finger and BTB domain-containing protein 20 isoform 2

    See identical proteins and their annotated locations for NP_001157819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093010, AC131152, BC029041, BC090936
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000418092.1, ENST00000481632.5
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  7. NM_001348800.3 → NP_001335729.1  zinc finger and BTB domain-containing protein 20 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1 and, like variant 1, encodes isoform 1.
    Source sequence(s)
    AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
    Consensus CDS
    CCDS54626.1
    UniProtKB/Swiss-Prot
    Q63HP6, Q8N6R5, Q9HC78, Q9Y410
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000501561.1, ENST00000675478.1
    Conserved Domains (7) summary
    PHA03169
    Location:352 → 442
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:580 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:378 → 571
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18208
    Location:79 → 195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634 → 656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648 → 673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608 → 657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  8. NM_001348801.3 → NP_001335730.1  zinc finger and BTB domain-containing protein 20 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  9. NM_001348802.3 → NP_001335731.1  zinc finger and BTB domain-containing protein 20 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  10. NM_001348803.3 → NP_001335732.1  zinc finger and BTB domain-containing protein 20 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1 and, like variant 1, encodes isoform 1.
    Source sequence(s)
    AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
    Consensus CDS
    CCDS54626.1
    UniProtKB/Swiss-Prot
    Q63HP6, Q8N6R5, Q9HC78, Q9Y410
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000419153.1, ENST00000474710.6
    Conserved Domains (7) summary
    PHA03169
    Location:352 → 442
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:580 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:378 → 571
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18208
    Location:79 → 195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634 → 656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648 → 673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608 → 657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  11. NM_001348804.3 → NP_001335733.1  zinc finger and BTB domain-containing protein 20 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  12. NM_001348805.3 → NP_001335734.1  zinc finger and BTB domain-containing protein 20 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC055739, AC069063, AC069506, AC078986, AC083886, AC092915, AC093010, AC131152
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  13. NM_001393393.1 → NP_001380322.1  zinc finger and BTB domain-containing protein 20 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055739, AC078986, AC083886, AC093010, AC131152
    Consensus CDS
    CCDS54626.1
    UniProtKB/Swiss-Prot
    Q63HP6, Q8N6R5, Q9HC78, Q9Y410
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000502480.1, ENST00000676079.1
    Conserved Domains (7) summary
    PHA03169
    Location:352 → 442
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:580 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:378 → 571
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18208
    Location:79 → 195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634 → 656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648 → 673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608 → 657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  14. NM_001393394.1 → NP_001380323.1  zinc finger and BTB domain-containing protein 20 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055739, AC078986, AC083886, AC093010, AC131152
    Consensus CDS
    CCDS54626.1
    UniProtKB/Swiss-Prot
    Q63HP6, Q8N6R5, Q9HC78, Q9Y410
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:352 → 442
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:580 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:378 → 571
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18208
    Location:79 → 195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634 → 656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648 → 673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608 → 657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  15. NM_001393395.1 → NP_001380324.1  zinc finger and BTB domain-containing protein 20 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055739, AC078986, AC083886, AC093010, AC131152
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  16. NM_001393396.1 → NP_001380325.1  zinc finger and BTB domain-containing protein 20 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055739, AC078986, AC083886, AC093010, AC131152
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  17. NM_015642.7 → NP_056457.3  zinc finger and BTB domain-containing protein 20 isoform 2

    See identical proteins and their annotated locations for NP_056457.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC069063, AC093010, AC131152, BC090936, BX647778
    Consensus CDS
    CCDS2981.1
    UniProtKB/TrEMBL
    A8K251, B2RCW4
    Related
    ENSP00000349803.3, ENST00000357258.8
    Conserved Domains (7) summary
    PHA03169
    Location:279 → 369
    PHA03169; hypothetical protein; Provisional
    COG5048
    Location:432 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6 → 122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561 → 583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535 → 584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RNA

  1. NR_121662.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three exons and contains mutliple alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC069506, AC093010, AC131152, CB164748, DA120543

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    114314500..115147288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    117035293..117867765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HC78.3 GenPept UniProtKB/Swiss-Prot:Q9HC78

Gene LinkOut

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