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ANAPC15 anaphase promoting complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 25906, updated on 2-Nov-2024

Summary

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Official Symbol
ANAPC15provided by HGNC
Official Full Name
anaphase promoting complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:24531
See related
Ensembl:ENSG00000110200 MIM:614717; AllianceGenome:HGNC:24531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC15; HSPC020; C11orf51
Summary
Involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 6.8), testis (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ANAPC15 in Genome Data Viewer
Location:
11q13.4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72106372..72112780, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72033262..72039670, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71817418..71823826, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3713 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71814909-71815429 Neighboring gene uncharacterized LOC124902837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71823011-71823548 Neighboring gene transmembrane O-methyltransferase Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71823549-71824086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71824087-71824624 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71849877-71850378 Neighboring gene folate receptor gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity. Li Q, et al. Proc Natl Acad Sci U S A, 2016 Sep 20. PMID 27601667, Free PMC Article
  2. The anaphase-promoting complex: a key factor in the regulation of cell cycle. Castro A, et al. Oncogene, 2005 Jan 13. PMID 15678131
  3. APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Uzunova K, et al. Nat Struct Mol Biol, 2012 Nov. PMID 23007861, Free PMC Article
  4. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Yau RG, et al. Cell, 2017 Nov 2. PMID 29033132, Free PMC Article
  5. Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. Sedgwick GG, et al. Oncogene, 2013 Sep 26. PMID 23160376, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cryo-EM structure of an APC/C-Cdh1 complex with Apc1(WD40) deleted showed that the mutant APC/C is locked into an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible
    Title: WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.
  2. Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 and mitotic checkpoint protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.
    Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
  3. APC15 is required for anaphase-promoting complex/cyclosome-bound mitotic checkpoint complex-dependent CDC20 autoubiquitylation and degradation and for timely anaphase initiation.
    Title: APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564M082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein branched polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278485.2 → NP_001265414.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001265414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 23-28 all encode the same isoform (a).
    Source sequence(s)
    AF077206, BG752082
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000443645.1, ENST00000545680.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  2. NM_001278486.2 → NP_001265415.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001265415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform a. Variants 1, 2, and 23-28 all encode the same isoform (a).
    Source sequence(s)
    AK222622, AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000439403.1, ENST00000543587.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  3. NM_001278487.2 → NP_001265416.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, AP000812, BG764016
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000440002.1, ENST00000538393.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  4. NM_001278488.2 → NP_001265417.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, AP000812, BU532056
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000443383.1, ENST00000535503.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  5. NM_001278489.2 → NP_001265418.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, CN306434
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000446412.1, ENST00000535234.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  6. NM_001278490.2 → NP_001265419.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, BU930156
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000446383.1, ENST00000545944.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  7. NM_001278491.1 → NP_001265420.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206, AP000812, BE616852
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  8. NM_001278492.2 → NP_001265421.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000443911.1, ENST00000542531.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  9. NM_001278493.2 → NP_001265422.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  10. NM_001278494.2 → NP_001265423.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001265423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000440983.1, ENST00000538919.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  11. NM_001330321.2 → NP_001317250.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate 3' terminal exon compared to variant 1. It encodes isoform c, which is longer than and has a distinct C-terminus compared to isoform a. Variants 12-17 all encode the same isoform (c).
    Source sequence(s)
    AP000812, HY166245
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Related
    ENSP00000437360.1, ENST00000543050.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  12. NM_001393427.1 → NP_001380356.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  13. NM_001393428.1 → NP_001380357.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  14. NM_001393429.1 → NP_001380358.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  15. NM_001393430.1 → NP_001380359.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  16. NM_001393431.1 → NP_001380360.1  anaphase-promoting complex subunit 15 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS81593.1
    UniProtKB/TrEMBL
    G5EA39
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  17. NM_001393432.1 → NP_001380361.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H6E4
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 60
    ANAPC15; Anaphase-promoting complex subunit 15

  18. NM_001393433.1 → NP_001380362.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H6E4
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 60
    ANAPC15; Anaphase-promoting complex subunit 15

  19. NM_001393434.1 → NP_001380363.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H6E4
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 60
    ANAPC15; Anaphase-promoting complex subunit 15

  20. NM_001393435.1 → NP_001380364.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H6E4
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 60
    ANAPC15; Anaphase-promoting complex subunit 15

  21. NM_001393436.1 → NP_001380365.1  anaphase-promoting complex subunit 15 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H6E4
    Related
    ENSP00000437683.1, ENST00000537644.5
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 60
    ANAPC15; Anaphase-promoting complex subunit 15

  22. NM_001393437.1 → NP_001380366.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  23. NM_001393438.1 → NP_001380367.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  24. NM_001393439.1 → NP_001380368.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  25. NM_001393440.1 → NP_001380369.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  26. NM_001393441.1 → NP_001380370.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  27. NM_001393442.1 → NP_001380371.1  anaphase-promoting complex subunit 15 isoform a

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS60880.1
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  28. NM_001393443.1 → NP_001380372.1  anaphase-promoting complex subunit 15 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  29. NM_001393444.1 → NP_001380373.1  anaphase-promoting complex subunit 15 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  30. NM_001393445.1 → NP_001380374.1  anaphase-promoting complex subunit 15 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP000812
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  31. NM_001393446.1 → NP_001380375.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  32. NM_001393447.1 → NP_001380376.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  33. NM_001393448.1 → NP_001380377.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  34. NM_001393449.1 → NP_001380378.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  35. NM_001393450.1 → NP_001380379.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  36. NM_001393451.1 → NP_001380380.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  37. NM_001393452.1 → NP_001380381.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  38. NM_001393453.1 → NP_001380382.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  39. NM_001393454.1 → NP_001380383.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  40. NM_001393455.1 → NP_001380384.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  41. NM_001393456.1 → NP_001380385.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  42. NM_001393457.1 → NP_001380386.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  43. NM_001393458.1 → NP_001380387.1  anaphase-promoting complex subunit 15 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  44. NM_001393459.1 → NP_001380388.1  anaphase-promoting complex subunit 15 isoform f

    Status: VALIDATED

    Source sequence(s)
    AP000812
    Consensus CDS
    CCDS91530.1
    UniProtKB/TrEMBL
    F5GWM6
    Related
    ENSP00000441774.1, ENST00000502597.2

  45. NM_014042.3 → NP_054761.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_054761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3-11 and 32-44 all encode the same isoform (b).
    Source sequence(s)
    AF077206
    Consensus CDS
    CCDS8210.1
    UniProtKB/Swiss-Prot
    G3V1Q3, P60006, Q9CXK2, Q9Y269
    UniProtKB/TrEMBL
    F5H3R3
    Related
    ENSP00000227618.4, ENST00000227618.9
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

RNA

  1. NR_171684.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812

  2. NR_171685.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812

  3. NR_171686.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812

  4. NR_171687.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000812

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    72106372..72112780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426723.1 → XP_047282679.1  anaphase-promoting complex subunit 15 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    72033262..72039670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368348.1 → XP_054224323.1  anaphase-promoting complex subunit 15 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60006.1 GenPept UniProtKB/Swiss-Prot:P60006

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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