Ddr1 discoidin domain receptor tyrosine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddr1provided by RGD
Official Full Name: discoidin domain receptor tyrosine kinase 1provided by RGD
Primary source: RGD:2252
See related: EnsemblRapid:ENSRNOG00000057125 AllianceGenome:RGD:2252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cak; Drd1; PTK3D
Summary: Predicted to enable collagen binding activity and protein tyrosine kinase collagen receptor activity. Involved in animal organ regeneration; collagen-activated tyrosine kinase receptor signaling pathway; and skin development. Located in basolateral plasma membrane and brush border. Used to study idiopathic pulmonary fibrosis. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast carcinoma; lung non-small cell carcinoma; osteosarcoma; and skin melanoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 202.8), Brain (RPKM 117.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3047269..3069277)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3042494..3064442)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3553430..3574959)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDR1 clustering, activation, and interaction with NMIIA filaments enhance the collagen tractional remodeling.
Title: Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction.
Discoidin domain receptor 1 may represent a molecular target for the prevention of blood-brain barrier disruption after cerebral ischemia/reperfusion injury.
Title: DDR1 may play a key role in destruction of the blood-brain barrier after cerebral ischemia-reperfusion.
regulation of DDRs by glucose
Title: Low stability and a conserved N-glycosylation site are associated with regulation of the discoidin domain receptor family by glucose via post-translational N-glycosylation.
A novel testis-specific Ddr1 transcript of 3.5 kb is described here which is expressed specifically in the postmeiotic germ cells of the rat testis.
Title: A novel discoidin domain receptor 1 (Ddr1) transcript is expressed in postmeiotic germ cells of the rat testis depending on the major histocompatibility complex haplotype.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase collagen receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in axon development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon development	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in ear development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ear development	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix disassembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of extracellular matrix disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin development	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in smooth muscle cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: epithelial discoidin domain-containing receptor 1

Names: CD167 antigen-like family member A; cell adhesion kinase; discoidin domain receptor family, member 1; discoidin receptor tyrosine kinase; epithelial discoidin domain receptor 1; neurotrophic tyrosine kinase receptor type 4; protein-tyrosine kinase 3; protein-tyrosine kinase PTK-3; tyrosine kinase DDR; tyrosine-protein kinase CAK

NP_001159494.1

EC 2.7.10.1

NP_037269.2

EC 2.7.10.1

XP_017457045.1

EC 2.7.10.1

XP_017457046.1

EC 2.7.10.1

XP_017457047.1

EC 2.7.10.1

XP_017457048.1

EC 2.7.10.1

XP_017457049.1

EC 2.7.10.1

XP_017457050.1

EC 2.7.10.1

XP_038954390.1

EC 2.7.10.1

XP_063135052.1

EC 2.7.10.1

XP_063135053.1

EC 2.7.10.1

XP_063135054.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166022.1 → NP_001159494.1 epithelial discoidin domain-containing receptor 1 precursor

See identical proteins and their annotated locations for NP_001159494.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC166604, BX883047, CB613563

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_013137.2 → NP_037269.2 epithelial discoidin domain-containing receptor 1 precursor

See identical proteins and their annotated locations for NP_037269.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC166604, BX883047, DN935615

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Related

ENSRNOP00000075331.1, ENSRNOT00000089417.3

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3047269..3069277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601558.3 → XP_017457047.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_063278982.1 → XP_063135052.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K7S7
XM_039098462.2 → XP_038954390.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_063278983.1 → XP_063135053.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K7S7
XM_017601556.3 → XP_017457045.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017601559.3 → XP_017457048.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017601560.3 → XP_017457049.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017601561.3 → XP_017457050.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2K7S7

Related

ENSRNOP00000098213.1, ENSRNOT00000120573.2

Conserved Domains (2) summary

cd05096
Location:564 → 867

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_017601557.3 → XP_017457046.1 epithelial discoidin domain-containing receptor 1 isoform X1

UniProtKB/Swiss-Prot

Q63474

UniProtKB/TrEMBL

A0A0G2KAB1, A6KT95, Q6MG19

Conserved Domains (2) summary

cd05096
Location:601 → 904

PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1

cd00057
Location:58 → 185

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
XM_063278984.1 → XP_063135054.1 epithelial discoidin domain-containing receptor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K7S7