Apoa2 apolipoprotein A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apoa2provided by RGD
Official Full Name: apolipoprotein A2provided by RGD
Primary source: RGD:2131
See related: EnsemblRapid:ENSRNOG00000003500 AllianceGenome:RGD:2131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: APOAII; Apo-AII; ApoA-II
Summary: Enables cholesterol transfer activity. Involved in several processes, including animal organ regeneration; response to estrogen; and response to glucocorticoid. Predicted to be located in extracellular space. Predicted to be part of chylomicron; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Biomarker of hyperthyroidism. Human ortholog(s) of this gene implicated in familial hypercholesterolemia. Orthologous to human APOA2 (apolipoprotein A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 12199.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86176767..86178819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83644460..83646358)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89596872..89598805)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ApoAII is efficiently reabsorbed in kidney proximal tubules in relation to its plasma concentration
Title: Apolipoprotein A-II is catabolized in the kidney as a function of its plasma concentration.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables apolipoprotein receptor binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in diacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol transporter activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of lipase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-methionine modification	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-methionine modification	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein oxidation	IEA Inferred from Electronic Annotation more info
involved_in protein oxidation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in triglyceride-rich lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chylomicron	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein A-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429558.1 → NP_001416487.1 apolipoprotein A-II precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P04638

UniProtKB/TrEMBL

A6JFV5
NM_013112.2 → NP_037244.1 apolipoprotein A-II preproprotein

See identical proteins and their annotated locations for NP_037244.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P04638

UniProtKB/TrEMBL

A6JFV5

Conserved Domains (1) summary

pfam04711
Location:24 → 98

ApoA-II; Apolipoprotein A-II (ApoA-II)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

86176767..86178819

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250238.4 → XP_006250300.1 apolipoprotein A-II isoform X1

Conserved Domains (1) summary

pfam04711
Location:24 → 98

ApoA-II; Apolipoprotein A-II (ApoA-II)
XM_006250239.4 → XP_006250301.1 apolipoprotein A-II isoform X1

Related

ENSRNOP00000004662.1, ENSRNOT00000004662.6

Conserved Domains (1) summary

pfam04711
Location:24 → 98

ApoA-II; Apolipoprotein A-II (ApoA-II)