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Nfyc nuclear transcription factor Y subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 25337, updated on 10-Oct-2024

Summary

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Official Symbol
Nfycprovided by RGD
Official Full Name
nuclear transcription factor Y subunit gammaprovided by RGD
Primary source
RGD:3173
See related
EnsemblRapid:ENSRNOG00000010735 AllianceGenome:RGD:3173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CBF-C
Summary
Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Part of CCAAT-binding activity factor complex. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 238.9), Heart (RPKM 228.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nfyc in Genome Data Viewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (139622020..139690545, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (134336802..134405372, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (139687442..139760154, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene uncharacterized LOC120102968 Neighboring gene uncharacterized LOC120102969 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene ribosomal protein S29, pseudogene 10 Neighboring gene regulating synaptic membrane exocytosis 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulated expression of NF-YC contributes to neuronal apoptosis via proapoptotic protein bim in rats' brain hippocampus following middle cerebral artery occlusion (MCAO). Wang Y, et al. J Mol Neurosci, 2014 Apr. PMID 24014123
  2. Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c. Teran-Garcia M, et al. Biochem J, 2007 Mar 15. PMID 17313375, Free PMC Article
  3. Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Sinha S, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878029, Free PMC Article
  4. NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons. Hughes R, et al. Cell Death Differ, 2011 Jun. PMID 21164521, Free PMC Article
  5. Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription. Liang F, et al. J Biol Chem, 2001 Jan 12. PMID 11022037

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of NF-YC might play an important role in the pathophysiology via proapoptotic protein Bim after middle cerebral artery occlusion.
    Title: Upregulated expression of NF-YC contributes to neuronal apoptosis via proapoptotic protein bim in rats' brain hippocampus following middle cerebral artery occlusion (MCAO).
  2. NF-Y cooperates with FOXO3a to recruit CBP/p300 to the bim promoter to form a stable multi-protein/DNA complex that activates bim transcription after survival factor withdrawal.
    Title: NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons.
  3. polyunsaturated fatty acids decrease in vivo binding of NF-Y and SREBP-1c to the proximal promoter of the hepatic fatty acid synthase gene
    Title: Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.
  4. NF-Y binds to p73 and transcriptionally regulates platelet derived growth factor beta receptor
    Title: p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear transcription factor Y subunit gamma
Names
CAAT box DNA-binding protein subunit C
CCAAT binding factor of CBF-C/NFY-C
CCAAT-binding transcription factor subunit C
NF-YC
nuclear transcription factor Y subunit C
nuclear transcription factor-Y gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429293.1 → NP_001416222.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q566C6, Q62725
    UniProtKB/TrEMBL
    A6IRZ3

  2. NM_001429294.1 → NP_001416223.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q566C6, Q62725
    UniProtKB/TrEMBL
    A6IRZ3

  3. NM_001429295.1 → NP_001416224.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q566C6, Q62725
    UniProtKB/TrEMBL
    A6IRZ3

  4. NM_001429296.1 → NP_001416225.1  nuclear transcription factor Y subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q566C6, Q62725
    UniProtKB/TrEMBL
    A6IRZ3

  5. NM_001429297.1 → NP_001416226.1  nuclear transcription factor Y subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  6. NM_012866.4 → NP_036998.1  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_036998.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q566C6, Q62725
    UniProtKB/TrEMBL
    A0A8L2R661, A6IRZ3
    Related
    ENSRNOP00000053489.2, ENSRNOT00000056651.6
    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    139622020..139690545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238785.5 → XP_006238847.1  nuclear transcription factor Y subunit gamma isoform X1

    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  2. XM_017593159.3 → XP_017448648.1  nuclear transcription factor Y subunit gamma isoform X1

    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

  3. XM_039109298.2 → XP_038965226.1  nuclear transcription factor Y subunit gamma isoform X2

    Conserved Domains (1) summary
    COG5208
    Location:17 → 123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62725.1 GenPept UniProtKB/Swiss-Prot:Q62725

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