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Htr1d 5-hydroxytryptamine receptor 1D [ Rattus norvegicus (Norway rat) ]

Gene ID: 25323, updated on 2-Nov-2024

Summary

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Official Symbol
Htr1dprovided by RGD
Official Full Name
5-hydroxytryptamine receptor 1Dprovided by RGD
Primary source
RGD:2847
See related
EnsemblRapid:ENSRNOG00000012038 AllianceGenome:RGD:2847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
5HT1D
Summary
Predicted to enable neurotransmitter receptor activity; serotonin binding activity; and transmembrane signaling receptor activity. Involved in regulation of synaptic vesicle exocytosis. Is active in glutamatergic synapse and neuronal dense core vesicle. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 6.7) See more
Orthologs
human mouse all
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Genomic context

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See Htr1d in Genome Data Viewer
Location:
5q36
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153939735..153960012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148656252..148676532)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154780958..154801505)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene uncharacterized LOC120103181 Neighboring gene aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like Neighboring gene leucine zipper protein 1 Neighboring gene lysine demethylase 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain. Ahn AH, et al. J Neurosci, 2006 Aug 9. PMID 16899728, Free PMC Article
  2. Nitric oxide-evoked glutamate release and cGMP production in cerebellar slices: control by presynaptic 5-HT1D receptors. Marcoli M, et al. Neurochem Int, 2006 Jul. PMID 16469416
  3. Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans. Potrebic S, et al. J Neurosci, 2003 Nov 26. PMID 14645495, Free PMC Article
  4. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. Maura G, et al. J Neurochem, 1996 Jan. PMID 8522955
  5. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats. Gharishvandi F, et al. Eur J Pharmacol, 2020 Sep 5. PMID 32574671

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protective effect of alpha7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
    Title: The protective effect of α7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
  2. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
    Title: Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
  3. 5-HTB/D receptors have a role in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
    Title: Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
  4. NXN-188 inhibits CGRP release from migraine-relevant cephalic tissues.
    Title: NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models.
  5. The mRNA and protein expressions of 5-HT1D receptor decreased in excessive fatigue rats and restraint stress rats.
    Title: [Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
  6. 5-HT(1B), 5-HT(1D)and 5-HT(1F) receptor expression are equally represented in trigeminal ganglia and the dorsal root ganglia.
    Title: Distribution of 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor expression in rat trigeminal and dorsal root ganglia neurons: relevance to the selective anti-migraine effect of triptans.
  7. vestibular ganglion cells were immunoreactive for 5-HT(1B) receptors in macaques and rats
    Title: Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.
  8. Moreover, the widespread expression of 5-HT1D receptor in somatic nociceptive afferents suggests that triptans could, in certain circumstances, treat pain in nontrigeminal regions of the body.
    Title: Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain.
  9. Presynaptic 5-HT1D receptors could regulate the nitric oxide-evoked release of glutamate and subsequent cGMP production.
    Title: Nitric oxide-evoked glutamate release and cGMP production in cerebellar slices: control by presynaptic 5-HT1D receptors.
  10. Our finding, that 5-HT1D receptors are distributed in nociceptors throughout the body, raises the possibility that triptans can regulate not only headache-associated pain but also nociceptive responses in extracranial tissues
    Title: Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled serotonin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables Gi/o-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding ISO
Inferred from Sequence Orthology
more info
  
enables serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of locomotion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine receptor 1D
Names
5 - Hydroxytryptamine (serotonin) receptor 1D
5-HT-1D
5-HT1D
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
serotonin receptor 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012852.2 → NP_036984.1  5-hydroxytryptamine receptor 1D

    See identical proteins and their annotated locations for NP_036984.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P28565
    UniProtKB/TrEMBL
    A6ITB2
    Related
    ENSRNOP00000104073.1, ENSRNOT00000171476.1
    Conserved Domains (1) summary
    cd15333
    Location:32 → 364
    7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153939735..153960012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28565.1 GenPept UniProtKB/Swiss-Prot:P28565

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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