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Cd247 Cd247 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 25300, updated on 2-Nov-2024

Summary

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Official Symbol
Cd247provided by RGD
Official Full Name
Cd247 moleculeprovided by RGD
Primary source
RGD:2305
See related
EnsemblRapid:ENSRNOG00000003298 AllianceGenome:RGD:2305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd3z; TCRzeta
Summary
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein tyrosine kinase binding activity. Involved in cell surface receptor signaling pathway. Part of T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 929.3), Spleen (RPKM 119.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Cd247 in Genome Data Viewer
Location:
13q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80576264..80651422)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78043302..78118437)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83996045..84071408)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096305 Neighboring gene cellular repressor of E1A-stimulated genes 1 Neighboring gene POU class 2 homeobox 1 Neighboring gene uncharacterized LOC134481526

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Rudemiller N, et al. Hypertension, 2014 Mar. PMID 24343121, Free PMC Article
  2. Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification. Angibaud J, et al. J Mol Neurosci, 2012 Feb. PMID 21809042
  3. The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons. Baudouin SJ, et al. Mol Biol Cell, 2008 Jun. PMID 18367546, Free PMC Article
  4. Effect of TNF-alpha on CD3-zeta and MHC-I in postnatal rat hippocampus. Sourial-Bassillious N, et al. Pediatr Res, 2006 Oct. PMID 16940250
  5. Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes. Tucek CL, et al. Int Immunol, 1992 Sep. PMID 1390434

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing.
    Title: Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3ζ in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats.
  2. functional T cells are required for the full development of Dahl salt-sensitive hypertension and indicate that the association between CD247 and hypertension in humans may be related to altered immune cell function.
    Title: CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.
  3. ectopic CD3zeta expression in neural precursor stem cells impaired their normal cell-fate specification. Variations of CD3zeta expression in the developing CNS might result in neurodevelopmental anomalies.
    Title: Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification.
  4. The transmembrane adaptor signaling protein CD3zeta, first described in the immune system, has a previously uncharacterized role in regulating neuronal development.
    Title: The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons.
  5. Tere is a robust postnatal up-regulation of CD3-zeta in rat hippocampus in early postnatal period.
    Title: Effect of TNF-alpha on CD3-zeta and MHC-I in postnatal rat hippocampus.
  6. experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta
    Title: Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Fc-gamma receptor III complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of T cell receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of alpha-beta T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha-beta T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell surface glycoprotein CD3 zeta chain
Names
CD247 antigen
CD3 antigen, zeta polypeptide
T-cell receptor CD3, subunit zeta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205304.1 → NP_001192233.1  T-cell surface glycoprotein CD3 zeta chain isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC097933, CO562119, JAXUCZ010000013
    UniProtKB/TrEMBL
    M0R576, Q4V7G0
    Related
    ENSRNOP00000104978.1, ENSRNOT00000143775.1
    Conserved Domains (2) summary
    pfam02189
    Location:112 → 131
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:28 → 58
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

  2. NM_170789.2 → NP_740770.2  T-cell surface glycoprotein CD3 zeta chain isoform 1

    See identical proteins and their annotated locations for NP_740770.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC097933, JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IDI4, F7FGL4, Q4V7G0
    Related
    ENSRNOP00000004403.5, ENSRNOT00000004403.10
    Conserved Domains (3) summary
    smart00077
    Location:69 → 89
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam02189
    Location:139 → 158
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:28 → 58
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80576264..80651422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250147.4 → XP_006250209.1  T-cell surface glycoprotein CD3 zeta chain isoform X1

    UniProtKB/TrEMBL
    A6IDI4
    Conserved Domains (3) summary
    smart00077
    Location:69 → 89
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam02189
    Location:138 → 157
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:28 → 58
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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