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Nr2c1 nuclear receptor subfamily 2, group C, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252924, updated on 2-Nov-2024

Summary

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Official Symbol
Nr2c1provided by RGD
Official Full Name
nuclear receptor subfamily 2, group C, member 1provided by RGD
Primary source
RGD:3200
See related
EnsemblRapid:ENSRNOG00000006983 AllianceGenome:RGD:3200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tr2; Psg4; TR2-11
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of retinoic acid receptor signaling pathway. Predicted to be located in PML body. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 44.6), Heart (RPKM 44.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nr2c1 in Genome Data Viewer
Location:
7q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30602338..30655610)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28715347..28768624)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35069807..35122810)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093556 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene U4 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene transmembrane and coiled-coil domain family 3 Neighboring gene uncharacterized LOC102554269

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein kinase C-mediated phosphorylation of orphan nuclear receptor TR2: effects on receptor stability and activity. Khan SA, et al. Proteomics, 2005 Oct. PMID 16130175
  2. The orphan nuclear receptor TR2 suppresses a DR4 hormone response element of the mouse CRABP-I gene promoter. Chinpaisal C, et al. Biochemistry, 1997 Nov 18. PMID 9369481
  3. Distinct expression patterns and biological activities of two isoforms of the mouse orphan receptor TR2. Lee CH, et al. J Endocrinol, 1997 Feb. PMID 9071982
  4. Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes. Lee CH, et al. Mol Reprod Dev, 1996 Jul. PMID 8858600
  5. A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2. Yu Z, et al. J Endocrinol, 1998 Oct. PMID 9795341

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 2 group C member 1
Names
nuclear receptor subfamily 2, group H, member 1
orphan nuclear receptor TR2
orphan receptor, TR2-11
pregnancy specific beta-1-glycoprotein 4
testicular receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145780.2 → NP_665723.1  nuclear receptor subfamily 2 group C member 1

    See identical proteins and their annotated locations for NP_665723.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q8VIJ4
    UniProtKB/TrEMBL
    A0A8L2R4T2
    Related
    ENSRNOP00000009578.1, ENSRNOT00000009578.6
    Conserved Domains (2) summary
    cd06952
    Location:355 → 576
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:96 → 182
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    30602338..30655610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078458.1 → XP_038934386.1  nuclear receptor subfamily 2 group C member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8VIJ4
    UniProtKB/TrEMBL
    A0A8L2R4T2
    Conserved Domains (2) summary
    cd06952
    Location:355 → 576
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:96 → 182
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  2. XM_017594671.3 → XP_017450160.1  nuclear receptor subfamily 2 group C member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8VIJ4
    UniProtKB/TrEMBL
    A0A8L2R4T2
    Conserved Domains (2) summary
    cd06952
    Location:355 → 576
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:96 → 182
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  3. XM_039078459.2 → XP_038934387.1  nuclear receptor subfamily 2 group C member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8VIJ4
    UniProtKB/TrEMBL
    A0A8L2R4T2
    Related
    ENSRNOP00000071901.3, ENSRNOT00000089228.3
    Conserved Domains (2) summary
    cd06952
    Location:355 → 576
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:96 → 182
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RNA

  1. XR_005486547.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VIJ4.1 GenPept UniProtKB/Swiss-Prot:Q8VIJ4

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