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St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25197, updated on 28-Oct-2024

Summary

Official Symbol
St6gal1provided by RGD
Official Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 1provided by RGD
Primary source
RGD:3676
See related
EnsemblRapid:ENSRNOG00000001823 AllianceGenome:RGD:3676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat1
Summary
Enables sialyltransferase activity. Involved in several processes, including negative regulation of macrophage apoptotic process; protein sialylation; and regulation of substrate adhesion-dependent cell spreading. Located in Golgi medial cisterna and Golgi trans cisterna. Used to study high grade glioma. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 1020.2), Kidney (RPKM 382.3) and 5 other tissues See more
Orthologs
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Genomic context

See St6gal1 in Genome Data Viewer
Location:
11q23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91031481..91158111, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77526837..77653474, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (80927601..80981424, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microtubule associated serine/threonine kinase 2, pseudogene 1 Neighboring gene uncharacterized LOC120095690 Neighboring gene ST6 beta-galactoside alpha-2,6-sialyltransferase 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in N-acetylneuraminate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in N-acetylneuraminate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of macrophage apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mononuclear cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
 
involved_in protein N-linked glycosylation via asparagine ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sialylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
 
involved_in sialylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 1
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6Gal I
ST6GalI
Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)
Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase)
alpha 2,6-ST 1
NP_001106815.1
NP_671738.2
XP_006248563.1
XP_038943921.1
XP_038943922.1
XP_038943923.1
XP_038943924.1
XP_038943925.1
XP_063126365.1
XP_063126366.1
XP_063126367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113344.1NP_001106815.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001106815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000011, M18769
    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_147205.2NP_671738.2  beta-galactoside alpha-2,6-sialyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_671738.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    BF418553, JAXUCZ010000011, M83143
    UniProtKB/TrEMBL
    F2Z3S3
    Related
    ENSRNOP00000002496.7, ENSRNOT00000002496.9
    Conserved Domains (1) summary
    pfam00777
    Location:63190
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    91031481..91158111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087995.2XP_038943923.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_063270296.1XP_063126366.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
  3. XM_039087993.2XP_038943921.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_006248501.3XP_006248563.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006248563.1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_039087996.2XP_038943924.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_039087994.2XP_038943922.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_063270295.1XP_063126365.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
  8. XM_063270297.1XP_063126367.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
  9. XM_039087997.2XP_038943925.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)