Calcrl calcitonin receptor like receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Calcrlprovided by RGD
Official Full Name: calcitonin receptor like receptorprovided by RGD
Primary source: RGD:2255
See related: EnsemblRapid:ENSRNOG00000054695 AllianceGenome:RGD:2255
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CLR; Crlr; RNCLR; RATCRLR
Summary: Predicted to enable adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in negative regulation of smooth muscle contraction. Is active in neuronal dense core vesicle and synaptic vesicle. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 818.4), Heart (RPKM 185.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (89835071..89932616, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (69428348..69525910, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (71747938..71845487, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endosomal signaling of the CLR mediates pain transmission.
Title: Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
TRPV1 in the lungs and CRLR and NK1R in the brainstem of rats can be upregulated by lung ischemia-reperfusion injury in a rapid manner.
Title: TRPV1 and neuropeptide receptor immunoreactivity and expression in the rat lung and brainstem after lung ischemia-reperfusion injury.
Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia.
Title: Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2).
Title: Adrenomedullin promotes rat trophoblast stem cell differentiation.
expression of adrenomedullin and the calcitonin receptor-like receptor system in the rat heart and sensory ganglia in experimentally-induced long-term diabetes
Title: Adrenomedullin and the calcitonin receptor-like receptor system mRNA expressions in the rat heart and sensory ganglia in experimentally-induced long-term diabetes.
It is concluded that the expression of gross and surface CRLR and RAMP1 were differentially regulated in primary neuronal cultures following morphine treatments, indicating the involvement of CGRP receptor in morphine associated functions.
Title: Expression of calcitonin gene-related peptide receptor subunits in cultured neurons following morphine treatment.
This study showed that CLR immunoreactivity was observed in satellite glial cells (SGCs) as well as in nerve fibers, but not in neurons.
Title: Calcitonin gene-related peptide and its receptor components in the human sphenopalatine ganglion -- interaction with the sensory system.
Data suggest that CGRP/CGRP receptor signaling plays role in a rat model of synovitis; blocking CGRP/CGRP receptor signal transduction could provide molecular targeted therapy for synovitis in rheumatoid arthritis or osteoarthritis.
Title: A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo.
Data demonstrate that there is a rich expression of calcitonin gene-related peptide (CGRP) and its receptor elements CLR and RAMP1 in the cerebellum which points towards a functional role of CGRP in cerebellar Purkinje cells.
Title: Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat.
CALCRL protein was found in neuromuscular junctions. Calcrl mRNA level was elevated 6 fold in the muscle endplate. 2 distinct Calcrl messages were alternatively spliced in a non-coding region so that only one translation product is generated.
Title: Calcitonin receptor-like receptor expression in rat skeletal muscle fibers.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:488324 (e-PCR)
- UniSTS:488324

D3Wox15 (e-PCR)
- UniSTS:517808

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adrenomedullin binding	IEA Inferred from Electronic Annotation more info
enables adrenomedullin binding	ISO Inferred from Sequence Orthology more info
enables adrenomedullin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adrenomedullin receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenomedullin receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcitonin gene-related peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in adrenomedullin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adrenomedullin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenomedullin receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcitonin gene-related peptide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcitonin gene-related peptide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sucrose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sucrose stimulus	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CGRP receptor complex	IEA Inferred from Electronic Annotation more info
part_of CGRP receptor complex	ISO Inferred from Sequence Orthology more info
part_of adrenomedullin receptor complex	IEA Inferred from Electronic Annotation more info
part_of adrenomedullin receptor complex	ISO Inferred from Sequence Orthology more info
part_of adrenomedullin receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcitonin gene-related peptide type 1 receptor

Names: CGRP type 1 receptor; calcitonin receptor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012717.3 → NP_036849.2 calcitonin gene-related peptide type 1 receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2R2X9

Conserved Domains (2) summary

cd15274
Location:137 → 410

7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:61 → 128

HRM; Hormone receptor domain