Myo5a myosin VA [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo5aprovided by RGD
Official Full Name: myosin VAprovided by RGD
Primary source: RGD:3143
See related: EnsemblRapid:ENSRNOG00000058866 AllianceGenome:RGD:3143
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dop; Myh12
Summary: Enables several functions, including ATP binding activity; ATP-dependent protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including cytoskeleton-dependent intracellular transport; positive regulation of cytochrome-c oxidase activity; and regulation of secretion by cell. Acts upstream of or within pigmentation. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Part of actomyosin, myosin complex part and ribonucleoprotein complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 616.0), Spleen (RPKM 175.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (84692524..84860564)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (75811985..75980049)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (82038966..82156507)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcium triggers the dissociation of myosin-Va from ribosomes in ribonucleoprotein complexes.
Title: Calcium triggers the dissociation of myosin-Va from ribosomes in ribonucleoprotein complexes.
myosin V acts as a vesicle tether at the plasma membrane, rather than a motor transporting vesicles to the release sites, or directly regulating vesicle exocytosis.
Title: Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses.
This study identified in vivo neuropathological and biochemical alterative changes involved in the pathogenesis of a spontaneous autosomal recessive movement disorder in a mutant Myo5a juvenile rat model.
Title: Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.
Insulin signaling to the molecular switch Rab8A connects with the motor protein MyoVa to mobilize GLUT4 vesicles toward the muscle cell plasma membrane.
Title: Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.
targeting of mRNAs to the dendrites is mediated by a mechanism that is dependent on actin and Myosin Va.
Title: Actin and myosin-dependent localization of mRNA to dendrites.
Data demonstrate that myosin-Va is a component of a heterogeneous population of ribonucleoprotein particles of different sizes and composition, both in brain and peripheral nervous system
Title: Myosin Va associates with mRNA in ribonucleoprotein particles present in myelinated peripheral axons and in the central nervous system.
Myosin-Va mediates cell-to-cell transfer of RNA from Schwann cells to axons.
Title: Myosin-Va-dependent cell-to-cell transfer of RNA from Schwann cells to axons.
Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Title: Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a.
Multiple binding partners of BR-MyoVa regulate SG transport, and this molecular mechanism is universally used by neuronal, endocrine and neuroendocrine cells.
Title: Molecular mechanism of myosin Va recruitment to dense core secretory granules.
Myosin-Va presented significantly lower levels of both mRNA and protein in diabetic than those observed in non-diabetic animals.
Title: The streptozotocin-induced rat model of diabetes mellitus evidences significant reduction of myosin-Va expression in the brain.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MYO5A (e-PCR)
- UniSTS:503148

RH139301 (e-PCR)
- UniSTS:221387

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in axo-dendritic protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of endoplasmic reticulum localization to postsynapse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytochrome-c oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in post-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive gliosis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in secretory granule localization	IDA Inferred from Direct Assay more info	PubMed
involved_in secretory granule localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretory granule localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along actin filament	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along actin filament	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along actin filament	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle transport along actin filament	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actomyosin	ISO Inferred from Sequence Orthology more info
part_of actomyosin, myosin complex part	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in insulin-responsive compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of unconventional myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-Va

Names: dilute myosin heavy chain, non-muscle; dilute-opisthotonus; myosin 5a; myosin-Va

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022178.2 → NP_071514.2 unconventional myosin-Va

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K9X3

Related

ENSRNOP00000075108.3, ENSRNOT00000091789.3

Conserved Domains (4) summary

COG1196
Location:1157 → 1417

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5022
Location:7 → 1275

COG5022; Myosin heavy chain [General function prediction only]

cd15478
Location:1454 → 1828

Myo5a_CBD; Cargo binding domain of myosin 5a

cd01380
Location:83 → 751

MYSc_Myo5; class V myosin, motor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

84692524..84860564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080847.2 → XP_038936775.1 unconventional myosin-Va isoform X1

UniProtKB/TrEMBL

A0A8I5ZJ51, A0A8I6A732

Related

ENSRNOP00000076388.1, ENSRNOT00000109142.2

Conserved Domains (3) summary

COG5022
Location:7 → 1445

COG5022; Myosin heavy chain [General function prediction only]

cd15478
Location:1503 → 1877

Myo5a_CBD; Cargo binding domain of myosin 5a

cd01380
Location:83 → 751

MYSc_Myo5; class V myosin, motor domain
XM_039080851.2 → XP_038936779.1 unconventional myosin-Va isoform X2

UniProtKB/TrEMBL

A0A8I6A732

Conserved Domains (4) summary

COG1196
Location:1157 → 1441

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5022
Location:7 → 1291

COG5022; Myosin heavy chain [General function prediction only]

cd15478
Location:1478 → 1852

Myo5a_CBD; Cargo binding domain of myosin 5a

cd01380
Location:83 → 751

MYSc_Myo5; class V myosin, motor domain
XM_039080852.2 → XP_038936780.1 unconventional myosin-Va isoform X3

UniProtKB/TrEMBL

A0A0G2K9S4

Conserved Domains (4) summary

COG1196
Location:1157 → 1439

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5022
Location:7 → 1291

COG5022; Myosin heavy chain [General function prediction only]

cd15478
Location:1476 → 1850

Myo5a_CBD; Cargo binding domain of myosin 5a

cd01380
Location:83 → 751

MYSc_Myo5; class V myosin, motor domain
XM_063264937.1 → XP_063121007.1 unconventional myosin-Va isoform X4
XM_063264938.1 → XP_063121008.1 unconventional myosin-Va isoform X5