Fmr1 fragile X messenger ribonucleoprotein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24948, updated on 27-Jul-2024

Summary

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Official Symbol: Fmr1provided by RGD
Official Full Name: fragile X messenger ribonucleoprotein 1provided by RGD
Primary source: RGD:2623
See related: EnsemblRapid:ENSRNOG00000057464 AllianceGenome:RGD:2623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FMRP
Summary: Enables several functions, including RNA binding activity; enzyme binding activity; and translation regulator activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of transport; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Part of polysome. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic cytosol. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of childhood onset epileptic encephalopathy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (FMRP translational regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 201.0), Lung (RPKM 137.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Fmr1 in Genome Data Viewer

Location:: Xq37

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (152284857..152322686)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (147240239..147278057)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (154684924..154722369, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function.
Title: Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function.
Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.
Title: Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.
FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability.
Title: FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability.
Expression and characterisation of Fmr1 splice variants during folliculogenesis in the rat.
Title: Expression and characterisation of Fmr1 splice variants during folliculogenesis in the rat.
Fmr1 exon 14 skipping in late embryonic development of the rat forebrain.
Title: Fmr1 exon 14 skipping in late embryonic development of the rat forebrain.
The same stress elicits different effects on anxiety-like behavior in rat models of Fmr1(-/y) and Pten(+/).
Title: The same stress elicits different effects on anxiety-like behavior in rat models of Fmr1(-/y) and Pten(+/).
FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis.
Title: FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis.
Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum.
Title: Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum.
Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant.
Title: Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant.
Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors.
Title: Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fmr1 (e-PCR), detects polymorphism
- UniSTS:478998

GDB:370773 (e-PCR)
- UniSTS:156827

L23971 (e-PCR)
- UniSTS:124883

GDB:342159 (e-PCR)
- UniSTS:156637

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	ISO Inferred from Sequence Orthology more info
enables G-quadruplex RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA strand annealing activity	ISO Inferred from Sequence Orthology more info
enables RNA strand annealing activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables poly(A) binding	ISO Inferred from Sequence Orthology more info
enables poly(G) binding	ISO Inferred from Sequence Orthology more info
enables poly(G) binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables siRNA binding	ISO Inferred from Sequence Orthology more info
enables siRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception	IEP Inferred from Expression Pattern more info	PubMed
involved_in evoked excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inhibitory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in intracellular glutamate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect miRNA-mediated post-transcriptional gene silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation by host of viral RNA genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in non-membrane-bounded organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in non-membrane-bounded organelle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular transport of viral material	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of modification of synaptic structure	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of translation at postsynapse, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation at presynapse, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation at presynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at presynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-17	ISO Inferred from Sequence Orthology more info
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of SMN complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in chromocenter	ISO Inferred from Sequence Orthology more info
located_in chromocenter	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic filopodium	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine neck	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium tip	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	ISS Inferred from Sequence or Structural Similarity more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone filopodium	ISO Inferred from Sequence Orthology more info
located_in growth cone filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
located_in spine apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fragile X messenger ribonucleoprotein 1

Names: FMRP translational regulator 1; protein FMR-1; synaptic functional regulator FMR1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431548.1 → NP_001418477.1 fragile X messenger ribonucleoprotein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001431611.1 → NP_001418540.1 fragile X messenger ribonucleoprotein 1 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001431612.1 → NP_001418541.1 fragile X messenger ribonucleoprotein 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001431613.1 → NP_001418542.1 fragile X messenger ribonucleoprotein 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001431614.1 → NP_001418543.1 fragile X messenger ribonucleoprotein 1 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_052804.3 → NP_434691.1 fragile X messenger ribonucleoprotein 1 isoform 2

See identical proteins and their annotated locations for NP_434691.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6KQ97

Conserved Domains (5) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

cd00105
Location:286 → 325

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam05641
Location:63 → 120

Agenet; Agenet domain

pfam12235
Location:398 → 538

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:516 → 581

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

152284857..152322686

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229532.5 → XP_006229594.1 fragile X messenger ribonucleoprotein 1 isoform X3

See identical proteins and their annotated locations for XP_006229594.1

UniProtKB/Swiss-Prot

P70568, Q80WE1

UniProtKB/TrEMBL

A6KQ98

Related

ENSRNOP00000074033.2, ENSRNOT00000087893.3

Conserved Domains (5) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

cd00105
Location:286 → 325

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam05641
Location:63 → 120

Agenet; Agenet domain

pfam12235
Location:398 → 550

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:528 → 593

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
XM_006229530.5 → XP_006229592.1 fragile X messenger ribonucleoprotein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JZV8

Related

ENSRNOP00000071204.1, ENSRNOT00000089743.3

Conserved Domains (6) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

cd00105
Location:286 → 325

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam05641
Location:63 → 120

Agenet; Agenet domain

pfam12235
Location:419 → 571

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:549 → 614

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

pfam16624
Location:314 → 392

zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger
XM_006229531.5 → XP_006229593.1 fragile X messenger ribonucleoprotein 1 isoform X2

Conserved Domains (6) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

pfam00013
Location:283 → 323

KH_1; KH domain

pfam05641
Location:63 → 120

Agenet; Agenet domain

pfam12235
Location:419 → 559

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:537 → 602

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

pfam16624
Location:314 → 392

zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger
XM_017601917.3 → XP_017457406.1 fragile X messenger ribonucleoprotein 1 isoform X4
XM_017601918.3 → XP_017457407.1 fragile X messenger ribonucleoprotein 1 isoform X5

Related

ENSRNOP00000099925.1, ENSRNOT00000173683.1
XM_039099491.2 → XP_038955419.1 fragile X messenger ribonucleoprotein 1 isoform X7

Conserved Domains (6) summary

pfam12235
Location:419 → 512

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

cd20471
Location:1 → 55

Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins

cd20474
Location:58 → 120

Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins

cd22506
Location:123 → 199

KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

cd22509
Location:218 → 280

KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

cl00098
Location:281 → 423

KH-I; K homology (KH) RNA-binding domain, type I
XM_063279814.1 → XP_063135884.1 fragile X messenger ribonucleoprotein 1 isoform X6
XM_063279816.1 → XP_063135886.1 fragile X messenger ribonucleoprotein 1 isoform X6
XM_063279815.1 → XP_063135885.1 fragile X messenger ribonucleoprotein 1 isoform X6