Tk1 thymidine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tk1provided by RGD
Official Full Name: thymidine kinase 1provided by RGD
Primary source: RGD:621014
See related: EnsemblRapid:ENSRNOG00000047314 AllianceGenome:RGD:621014
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tk
Summary: Enables identical protein binding activity. Involved in several processes, including fetal process involved in parturition; response to cortisol; and thymidine metabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human TK1 (thymidine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 260.9), Thymus (RPKM 147.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (103533449..103544818, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103034755..103046125, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (106817556..106828888, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A cytosolic form of TK2 was identified in all tested tissues in addition to mitochondrial TK2. TK1 was detected in liver and spleen cytosolic extracts while dCK was found in liver, spleen and lung cytosolic extracts.
Title: Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
These results suggest that the expression of HSV1-TK in testes brings about not only abnormal spermiogenesis but also a loss of germ cells due to apoptosis.
Title: HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells.
Thymidine kinase 1 is a molecular target for boron neutron capture therapy of brain tumors.
Title: Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables thymidine kinase activity	IEA Inferred from Electronic Annotation more info
enables thymidine kinase activity	ISO Inferred from Sequence Orthology more info
enables thymidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in mitotic DNA replication	ISO Inferred from Sequence Orthology more info
involved_in deoxyribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in fetal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cortisol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in thymidine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in thymidine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thymidine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymidine kinase, cytosolic

Names: thymidine kinase 1, soluble

NP_434687.1

EC 2.7.1.21

XP_017452506.1

EC 2.7.1.21

XP_038941153.1

EC 2.7.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052800.1 → NP_434687.1 thymidine kinase, cytosolic

See identical proteins and their annotated locations for NP_434687.1

Status: VALIDATED

Source sequence(s)

AW919734, BF547747, BP495650, CK471539, CV072953, EV770793, M22642

UniProtKB/TrEMBL

A6HL31, M0RCX2

Related

ENSRNOP00000067459.2, ENSRNOT00000071420.4

Conserved Domains (1) summary

cl23762
Location:18 → 197

TK; Thymidine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

103533449..103544818 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597017.3 → XP_017452506.1 thymidine kinase, cytosolic isoform X1

UniProtKB/TrEMBL

A6HL32, M0RCX2

Conserved Domains (1) summary

cl23762
Location:1 → 161

TK; Thymidine kinase
XM_039085225.2 → XP_038941153.1 thymidine kinase, cytosolic isoform X2

Related

ENSRNOP00000112471.1, ENSRNOT00000142849.1

Conserved Domains (1) summary

cl23762
Location:18 → 70

TK; Thymidine kinase