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Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24679, updated on 14-Nov-2024

Summary

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Official Symbol
Prkar2bprovided by RGD
Official Full Name
protein kinase cAMP-dependent type II regulatory subunit betaprovided by RGD
Primary source
RGD:3394
See related
EnsemblRapid:ENSRNOG00000009079 AllianceGenome:RGD:3394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RATDNA
Summary
Enables cAMP binding activity; cAMP-dependent protein kinase regulator activity; and protein domain specific binding activity. Involved in regulation of protein kinase activity and response to antipsychotic drug. Located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 683.9), Adrenal (RPKM 590.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prkar2b in Genome Data Viewer
Location:
6q16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (54291143..54381639, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48563659..48653933, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (51265509..51356383, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22 Neighboring gene large ribosomal subunit protein eL20-like Neighboring gene HMG-box transcription factor 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134479360 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the GC-rich and cyclic adenosine 3',5'-monophosphate (cAMP)-inducible promoter of the type II beta cAMP-dependent protein kinase regulatory subunit gene. Kurten RC, et al. Mol Endocrinol, 1992 Apr. PMID 1316546
  2. The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study. Blumenthal DK, et al. J Biol Chem, 2014 Oct 10. PMID 25112875, Free PMC Article
  3. Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells. Jahnsen T, et al. J Biol Chem, 1986 Sep 15. PMID 2427518
  4. Molecular cloning, cDNA structure and deduced amino acid sequence for the hormone-induced regulatory subunit (RII beta) of cAMP-dependent protein kinase from rat ovarian granulosa cells. Sandberg M, et al. Biochem Biophys Res Commun, 1988 Jul 29. PMID 3401231
  5. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. Zawadzki KM, et al. J Biol Chem, 2004 Feb 20. PMID 14625280

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit.
    Title: Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.
  2. The unique structural properties of RiIbeta do not require the C-terminal cAMP-binding domain.
    Title: The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.
  3. study describes the 2.3 angstrom structure of full-length tetrameric RIIbeta(2):C(2) holoenzyme
    Title: Structure and allostery of the PKA RIIβ tetrameric holoenzyme.
  4. The novel orientation of the linker peptide provides the first clues as to how this region contributes to the unique organization of the RIIbeta holoenzyme.
    Title: Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.
  5. InsP3R1 forms a complex with AKAP450 and PKAIIbeta, localized in the Golgi apparatus of cerebellar granule cells.
    Title: Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells.
  6. Direct evidence is provided that the type II beta protein kinase A regulatory subunit may be partially associated with the type I alpha catalytic subunit with the pseudosubstrate sequence docked in the active site cleft in the presence of cAMP.
    Title: Probing cAMP-dependent protein kinase holoenzyme complexes I alpha and II beta by FT-IR and chemical protein footprinting.
  7. the B domain of type II beta regulatory subunit of cAMP-dependent protein kinase inhibits holoenzyme activation for RIIbeta
    Title: cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116401

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A catalytic subunit binding IC
Inferred by Curator
more info
 PubMed 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP/PKA signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to antipsychotic drug IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase type II-beta regulatory subunit
Names
Type II beta regulatory subunit of cAMP-dependent protein kinase
protein kinase cAMP-dependent type 2 regulatory subunit beta
protein kinase, cAMP dependent regulatory, type II beta
protein kinase, cAMP-dependent, regulatory subunit type II beta
NP_001025191.1
XP_017449526.3
XP_063117623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030020.1 → NP_001025191.1  cAMP-dependent protein kinase type II-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001025191.1

    Status: VALIDATED

    Source sequence(s)
    BI298837, CB814252, CX569141, M12492
    UniProtKB/Swiss-Prot
    P12369
    UniProtKB/TrEMBL
    A6HB59
    Related
    ENSRNOP00000012415.6, ENSRNOT00000012415.8
    Conserved Domains (2) summary
    cd12104
    Location:3 → 43
    DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:274 → 394
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    54291143..54381639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594037.3 → XP_017449526.3  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1

    Related
    ENSRNOP00000074658.1, ENSRNOT00000079719.3

  2. XM_063261553.1 → XP_063117623.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12369.3 GenPept UniProtKB/Swiss-Prot:P12369

Gene LinkOut

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