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Kcnh8 potassium voltage-gated channel subfamily H member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246325, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnh8provided by RGD
Official Full Name
potassium voltage-gated channel subfamily H member 8provided by RGD
Primary source
RGD:2549
See related
EnsemblRapid:ENSRNOG00000058626 AllianceGenome:RGD:2549
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ELK3; Elk1; Ets-1; RELK3
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Involved in negative regulation of apoptotic process; potassium ion transport; and response to aldosterone. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of retinal degeneration. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 7.2), Testes (RPKM 1.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnh8 in Genome Data Viewer
Location:
9q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (5742683..6182445)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (5506044..5945828)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (3127618..3697736, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Fcf1 rRNA-processing protein, pseudogene 6 Neighboring gene uncharacterized LOC134480318 Neighboring gene uncharacterized LOC134480321 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134480320 Neighboring gene ribosomal protein S17, pseudogene 11 Neighboring gene ribosomal protein S26, pseudogene 12 Neighboring gene cofilin 1, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Martin S, et al. Neuroscience, 2008 Aug 26. PMID 18650019
  2. Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter. Zhang C, et al. J Biol Chem, 2003 Jul 25. PMID 12740370
  3. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. Saganich MJ, et al. J Neurosci, 2001 Jul 1. PMID 11425889, Free PMC Article
  4. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. Engeland B, et al. J Physiol, 1998 Dec 15. PMID 9824707, Free PMC Article
  5. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. Shi W, et al. J Physiol, 1998 Sep 15. PMID 9714851, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that Eag1 protein expression greatly overlaps with mRNA distribution in rat.
    Title: Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delayed rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to aldosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-gated delayed rectifier potassium channel KCNH8
Names
ELK channel 3
ether-a-go-go-like potassium channel 1
ether-a-go-go-like potassium channel 3
potassium channel, voltage gated eag related subfamily H, member 8
potassium voltage-gated channel, subfamily H (eag-related), member 8
voltage-gated potassium channel subunit Kv12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145095.2 → NP_659563.1  voltage-gated delayed rectifier potassium channel KCNH8

    See identical proteins and their annotated locations for NP_659563.1

    Status: PROVISIONAL

    Source sequence(s)
    AF061957
    UniProtKB/Swiss-Prot
    O88877, Q9QWS8
    UniProtKB/TrEMBL
    A6KPQ1
    Related
    ENSRNOP00000074122.3, ENSRNOT00000087331.3
    Conserved Domains (6) summary
    COG0664
    Location:548 → 707
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:551 → 662
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:42 → 133
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:239 → 481
    Ion_trans; Ion transport protein
    pfam07885
    Location:421 → 475
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 135
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    5742683..6182445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWS8.2 GenPept UniProtKB/Swiss-Prot:Q9QWS8

Gene LinkOut

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