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Man2c1 mannosidase, alpha, class 2C, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246136, updated on 2-Nov-2024

Summary

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Official Symbol
Man2c1provided by RGD
Official Full Name
mannosidase, alpha, class 2C, member 1provided by RGD
Primary source
RGD:628787
See related
EnsemblRapid:ENSRNOG00000030654 AllianceGenome:RGD:628787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AMAN
Summary
Enables alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 195.5), Adrenal (RPKM 169.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Man2c1 in Genome Data Viewer
Location:
8q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66434480..66445649)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57537879..57549691)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61805697..61816800)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094171 Neighboring gene SIN3 transcription regulator family member A Neighboring gene uncharacterized LOC120094172 Neighboring gene nei-like DNA glycosylase 1 Neighboring gene COMM domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase. Bischoff J, et al. J Biol Chem, 1990 Oct 5. PMID 2211613
  2. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93158

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-mannosidase 2C1
Names
alpha-D-mannoside mannohydrolase
NP_640349.2
XP_038936749.1
XP_038936750.1
XP_038936752.1
XP_063120986.1
XP_063120987.1
XP_063120988.1
XP_063120989.1
XP_063120990.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139256.2 → NP_640349.2  alpha-mannosidase 2C1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    F1LPQ3, Q5M9I2
    Related
    ENSRNOP00000041867.5, ENSRNOT00000048318.7
    Conserved Domains (2) summary
    cd10813
    Location:251 → 502
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:67 → 1034
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66434480..66445649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264920.1 → XP_063120990.1  alpha-mannosidase 2C1 isoform X8

  2. XM_063264916.1 → XP_063120986.1  alpha-mannosidase 2C1 isoform X1

  3. XM_063264917.1 → XP_063120987.1  alpha-mannosidase 2C1 isoform X2

  4. XM_039080821.2 → XP_038936749.1  alpha-mannosidase 2C1 isoform X3

    UniProtKB/TrEMBL
    F1LPQ3
    Related
    ENSRNOP00000110370.1, ENSRNOT00000171959.1
    Conserved Domains (2) summary
    cd10813
    Location:277 → 528
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:93 → 1008
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  5. XM_063264919.1 → XP_063120989.1  alpha-mannosidase 2C1 isoform X6

  6. XM_039080824.2 → XP_038936752.1  alpha-mannosidase 2C1 isoform X7

    Conserved Domains (2) summary
    cd10813
    Location:277 → 528
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:93 → 625
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

  7. XM_063264918.1 → XP_063120988.1  alpha-mannosidase 2C1 isoform X4

  8. XM_039080822.2 → XP_038936750.1  alpha-mannosidase 2C1 isoform X5

    UniProtKB/TrEMBL
    F1LPQ3
    Conserved Domains (2) summary
    cd10813
    Location:189 → 440
    GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:190 → 972
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21139.1 GenPept UniProtKB/Swiss-Prot:P21139

Gene LinkOut

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