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Ina internexin neuronal intermediate filament protein, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24503, updated on 2-May-2024

Summary

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Official Symbol
Inaprovided by RGD
Official Full Name
internexin neuronal intermediate filament protein, alphaprovided by RGD
Primary source
RGD:2911
See related
Ensembl:ENSRNOG00000020248 AllianceGenome:RGD:2911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nf66; Inexa; Intlaa; alpha-Inx
Summary
Predicted to be a structural constituent of postsynaptic actin cytoskeleton and structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in tissue regeneration. Is active in glutamatergic synapse and postsynaptic intermediate filament cytoskeleton. Orthologous to human INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 171.6) See more
Orthologs
human mouse all
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Genomic context

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See Ina in Genome Data Viewer
Location:
1q54
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255838129..255849680)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245896775..245908330)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266782835..266794389)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene uncharacterized LOC134484086 Neighboring gene transfer RNA arginine (anticodon UCU) 2 Neighboring gene polycomb group ring finger 6 Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene ATP synthase membrane subunit K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Anti-alpha-internexin autoantibody from neuropsychiatric lupus induce cognitive damage via inhibiting axonal elongation and promote neuron apoptosis. Lu XY, et al. PLoS One, 2010 Jun 15. PMID 20559547, Free PMC Article
  2. Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells. Chien CL, et al. J Neurosci Res, 2005 Jun 1. PMID 15880430
  3. alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury. Dickson TC, et al. Neurobiol Dis, 2005 Mar. PMID 15686957
  4. Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons. McGraw TS, et al. J Neurosci, 2002 Jun 15. PMID 12077192, Free PMC Article
  5. Excitable membranes and synaptic transmission: postsynaptic mechanisms. Localization of alpha-internexin in the postsynaptic density of the rat brain. Suzuki T, et al. Brain Res, 1997 Aug 8. PMID 9310396

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recombinant rat alpha-internexin coassembles with all three neurofilament proteins into a single network of filaments in quadruple-transfected SW13vim(-) mouse cells.
    Title: Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.
  2. Alpha-internexin immunoreactive neurites were localized to plaques densely packed with beta-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport.
    Title: alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury.
  3. alpha-internexin plays an important role in neurite outgrowth and regulates the expression of other neurofilaments during neuronal development
    Title: Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of postsynaptic intermediate filament cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of postsynaptic intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of postsynaptic intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurofilament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurofilament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neurofilament IEA
Inferred from Electronic Annotation
more info
  
located_in neurofilament ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic intermediate filament cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-internexin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019128.5 → NP_062001.2  alpha-internexin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P23565
    UniProtKB/TrEMBL
    A6JHP2, G3V8Q2
    Related
    ENSRNOP00000027417.5, ENSRNOT00000027417.7
    Conserved Domains (2) summary
    pfam00038
    Location:93 → 406
    Filament; Intermediate filament protein
    pfam04732
    Location:10 → 92
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255838129..255849680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23565.2 GenPept UniProtKB/Swiss-Prot:P23565

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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