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Nr3c1 nuclear receptor subfamily 3, group C, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24413, updated on 14-Nov-2024

Summary

Official Symbol
Nr3c1provided by RGD
Official Full Name
nuclear receptor subfamily 3, group C, member 1provided by RGD
Primary source
RGD:2741
See related
EnsemblRapid:ENSRNOG00000014096 AllianceGenome:RGD:2741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GR; Gcr; Grl
Summary
Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to magnesium ion; positive regulation of macromolecule biosynthetic process; and response to glucocorticoid. Located in dendritic spine and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including cocaine abuse; congestive heart failure; obesity; opioid abuse; and type 2 diabetes mellitus. Biomarker of several diseases, including brain disease (multiple); end stage renal disease; muscular atrophy; polycystic ovary syndrome; and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 441.4), Muscle (RPKM 375.5) and 9 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Nr3c1 in Genome Data Viewer
Location:
18p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (31522783..31644508, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (31271681..31393320, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31728373..32704022, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC134482936 Neighboring gene uncharacterized LOC100911367 Neighboring gene poly(A) binding protein, cytoplasmic 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear glucocorticoid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables steroid binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid hormone binding IEA
Inferred from Electronic Annotation
more info
 
enables steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adrenal gland development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adrenal gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to dexamethasone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to steroid hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in glucocorticoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucocorticoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lung development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within maternal behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in microglia differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in microglia differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in motor behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in motor behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle atrophy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear receptor-mediated corticosteroid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear receptor-mediated glucocorticoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear receptor-mediated glucocorticoid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucocorticoid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glucocorticoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to corticosterone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to inactivity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408897.1NP_001395826.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6J3I0
  2. NM_012576.3NP_036708.2  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_036708.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    O08624, P06536, Q8R463, Q8R5J0
    UniProtKB/TrEMBL
    A6J3I0, A8IRI3
    Conserved Domains (3) summary
    cd07076
    Location:548794
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:435512
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27420
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    31522783..31644508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277088.1XP_063133158.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    A6J3I0
    Related
    ENSRNOP00000108341.1, ENSRNOT00000146770.1
  2. XM_017600843.3XP_017456332.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    O08624, P06536, Q8R463, Q8R5J0
    UniProtKB/TrEMBL
    A8IRI3, E9PT44
  3. XM_063277086.1XP_063133156.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    A6J3I0
  4. XM_017600844.3XP_017456333.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    O08624, P06536, Q8R463, Q8R5J0
    UniProtKB/TrEMBL
    A8IRI3, E9PT44
  5. XM_063277087.1XP_063133157.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    A6J3I0
  6. XM_063277082.1XP_063133152.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    E9PT44
  7. XM_017600841.3XP_017456330.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    O08624, P06536, Q8R463, Q8R5J0
    UniProtKB/TrEMBL
    A8IRI3, E9PT44
  8. XM_017600839.3XP_017456328.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    O08624, P06536, Q8R463, Q8R5J0
    UniProtKB/TrEMBL
    A8IRI3, E9PT44
    Related
    ENSRNOP00000044335.5, ENSRNOT00000044287.6
  9. XM_063277083.1XP_063133153.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    E9PT44
  10. XM_017600840.3XP_017456329.1  glucocorticoid receptor isoform X1

    UniProtKB/Swiss-Prot
    O08624, P06536, Q8R463, Q8R5J0
    UniProtKB/TrEMBL
    A8IRI3, E9PT44
  11. XM_063277085.1XP_063133155.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    A6J3I0
  12. XM_063277084.1XP_063133154.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    E9PT44
  13. XM_063277089.1XP_063133159.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    A6J3I0