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Gpr161 G protein-coupled receptor 161 [ Mus musculus (house mouse) ]

Gene ID: 240888, updated on 14-Nov-2024

Summary

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Official Symbol
Gpr161provided by MGI
Official Full Name
G protein-coupled receptor 161provided by MGI
Primary source
MGI:MGI:2685054
See related
Ensembl:ENSMUSG00000040836 AllianceGenome:MGI:2685054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vl; Gm208; Gm208Gpr
Summary
Enables G protein-coupled receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in several cellular components, including cilium; glial cell projection; and recycling endosome. Is expressed in several structures, including central nervous system; eye; and limb. Human ortholog(s) of this gene implicated in medulloblastoma. Orthologous to human GPR161 (G protein-coupled receptor 161). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 9.4), CNS E18 (RPKM 9.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr161 in Genome Data Viewer
Location:
1 H2.2; 1 72.64 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165108760..165154314)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165281184..165326747)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene T-box 19 Neighboring gene STARR-seq mESC enhancer starr_02894 Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ultrastructural defects in the apical neural folds in mutant embryos with spina bifida. Wilson DB, et al. Acta Neuropathol, 1989. PMID 2686337
  2. Closure of the posterior neuropore in the vl mutant mouse. Wilson DB, et al. Anat Embryol (Berl), 1988. PMID 3223614
  3. In vitro expression of neural tube pathology in the vl mutant mouse. Wilson DB, et al. J Neuropathol Exp Neurol, 1993 May. PMID 8492142
  4. Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development. Kim SE, et al. Development, 2024 Oct 1. PMID 39369306,
  5. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia. Shinde SR, et al. J Cell Biol, 2020 Dec 7. PMID 33185668, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development.
    Title: Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development.
  2. Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner.
    Title: Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner.
  3. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
    Title: Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
  4. Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.
    Title: Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.
  5. Gpr161 restricts cerebellar granule cell progenitor production by preventing premature and sonic hedgehog-dependent pathway activity, highlighting the importance of basal pathway suppression in tumorigenesis
    Title: Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.
  6. Gpr161 promotes forelimb formation, regulates limb patterning, prevents periarticular chondrocyte proliferation and drives osteoblastogenesis in intramembranous bones in a cilium-dependent manner.
    Title: The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner.
  7. These studies demonstrate that modification of the Gpr161vl/vl cataract phenotype is likely due to genetic variants in at least one of three closely linked candidate genes on proximal Chromosome 15.
    Title: Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.
  8. Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
    Title: Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
  9. Gpr161 is a G-protein coupled receptor that regulates the retinoic acid and canonical Wnt pathways during neurulation
    Title: The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation.
  10. Complete loss of Gpr161 in mouse causes midgestation lethality and increased Shh signaling in the neural tube, phenocopying Tulp3/IFT-A mutants.
    Title: The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Associated conditions

Description Tests
vacuolated lens
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Spontaneous (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor 161

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081126.2 → NP_001074595.1  G-protein coupled receptor 161 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC116374, AK145635, BE991962, BY731738, CN721893
    UniProtKB/Swiss-Prot
    B2RPY5
    Conserved Domains (2) summary
    pfam00001
    Location:73 → 353
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:64 → 270
    7tm_4; Olfactory receptor

  2. NM_001310429.1 → NP_001297358.1  G-protein coupled receptor 161 isoform 2

    See identical proteins and their annotated locations for NP_001297358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC116374, BC137659, BE991962, BY731738, CN721893
    Consensus CDS
    CCDS83621.1
    UniProtKB/Swiss-Prot
    B0L0L8, B2RPY5, J3QN69, Q80T48
    Related
    ENSMUSP00000136621.3, ENSMUST00000178700.8
    Conserved Domains (2) summary
    pfam00001
    Location:60 → 340
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 257
    7tm_4; Olfactory receptor

  3. NM_001310430.1 → NP_001297359.1  G-protein coupled receptor 161 isoform 3

    See identical proteins and their annotated locations for NP_001297359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC116374, AK145635, BE991962
    Consensus CDS
    CCDS78732.1
    UniProtKB/TrEMBL
    A0A140T8Q9
    Related
    ENSMUSP00000107077.3, ENSMUST00000111450.3
    Conserved Domains (1) summary
    cd15214
    Location:28 → 334
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165108760..165154314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496851.5 → XP_006496914.1  G-protein coupled receptor 161 isoform X1

    See identical proteins and their annotated locations for XP_006496914.1

    UniProtKB/TrEMBL
    A0A140T8Q9
    Conserved Domains (1) summary
    cd15214
    Location:28 → 334
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_011238821.4 → XP_011237123.1  G-protein coupled receptor 161 isoform X1

    See identical proteins and their annotated locations for XP_011237123.1

    UniProtKB/TrEMBL
    A0A140T8Q9
    Conserved Domains (1) summary
    cd15214
    Location:28 → 334
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006496850.5 → XP_006496913.1  G-protein coupled receptor 161 isoform X1

    See identical proteins and their annotated locations for XP_006496913.1

    UniProtKB/TrEMBL
    A0A140T8Q9
    Conserved Domains (1) summary
    cd15214
    Location:28 → 334
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_006496852.5 → XP_006496915.1  G-protein coupled receptor 161 isoform X1

    See identical proteins and their annotated locations for XP_006496915.1

    UniProtKB/TrEMBL
    A0A140T8Q9
    Conserved Domains (1) summary
    cd15214
    Location:28 → 334
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RPY5.1 GenPept UniProtKB/Swiss-Prot:B2RPY5

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