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St6gal2 beta galactoside alpha 2,6 sialyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 240119, updated on 2-Nov-2024

Summary

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Official Symbol
St6gal2provided by MGI
Official Full Name
beta galactoside alpha 2,6 sialyltransferase 2provided by MGI
Primary source
MGI:MGI:2445190
See related
Ensembl:ENSMUSG00000024172 AllianceGenome:MGI:2445190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
St6galII; mKIAA1877; C230064G14Rik
Summary
Enables sialyltransferase activity. Predicted to be involved in oligosaccharide metabolic process and sialylation. Predicted to act upstream of or within N-acetylneuraminate metabolic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system; genitourinary system; lung; skeletal muscle; and spleen. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 9.2), whole brain E14.5 (RPKM 5.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See St6gal2 in Genome Data Viewer
Location:
17 C; 17 28.82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (55752071..55821582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55445118..55514581)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42865 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42866 Neighboring gene STARR-seq mESC enhancer starr_42867 Neighboring gene predicted gene 4471 Neighboring gene STARR-seq mESC enhancer starr_42868 Neighboring gene vomeronasal 2, receptor 118 Neighboring gene predicted gene, 22654 Neighboring gene protection of telomeres 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes. Ohmi Y, et al. Glycobiology, 2021 Jun 3. PMID 33242079
  2. Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II. Krzewinski-Recchi MA, et al. Eur J Biochem, 2003 Mar. PMID 12603328
  3. Comparison of the enzymatic properties of mouse beta-galactoside alpha2,6-sialyltransferases, ST6Gal I and II. Takashima S, et al. J Biochem, 2003 Aug. PMID 12966079
  4. Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Alderman PJ, et al. Neuron, 2024 Feb 21. PMID 38086370,
  5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
    Title: Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within N-acetylneuraminate metabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 2
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
beta-galactoside alpha-2,6-sialyltransferase II
NP_001334332.1
XP_006524330.1
XP_006524331.1
XP_006524332.1
XP_030105661.1
XP_030105662.1
XP_036016499.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347403.1 → NP_001334332.1  beta-galactoside alpha-2,6-sialyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    BE991433, CT009635
    Consensus CDS
    CCDS84324.1
    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Related
    ENSMUSP00000025000.4, ENSMUST00000025000.4
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    55752071..55821582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524267.4 → XP_006524330.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006524330.1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_030249801.2 → XP_030105661.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006524268.4 → XP_006524331.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006524331.1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_030249802.2 → XP_030105662.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_006524269.3 → XP_006524332.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006524332.1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_036160606.1 → XP_036016499.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276 → 506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_004939531.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172829.2: Suppressed sequence

    Description
    NM_172829.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76K27.2 GenPept UniProtKB/Swiss-Prot:Q76K27

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