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Klf6 Kruppel-like transcription factor 6 [ Mus musculus (house mouse) ]

Gene ID: 23849, updated on 2-Nov-2024

Summary

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Official Symbol
Klf6provided by MGI
Official Full Name
Kruppel-like transcription factor 6provided by MGI
Primary source
MGI:MGI:1346318
See related
Ensembl:ENSMUSG00000000078 AllianceGenome:MGI:1346318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FM2; FM6; Zf9; BCD1; CPBP; Copeb; Ierepo1; Ierepo3
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of connective tissue replacement. Acts upstream of or within cytokine-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 23.3), bladder adult (RPKM 19.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Klf6 in Genome Data Viewer
Location:
13 A1; 13 2.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (5911488..5920392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (5861489..5870393)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33546 Neighboring gene RIKEN cDNA 1700016G22 gene Neighboring gene STARR-seq mESC enhancer starr_33549 Neighboring gene predicted gene, 35464 Neighboring gene STARR-positive B cell enhancer ABC_E1867 Neighboring gene STARR-seq mESC enhancer starr_33553 Neighboring gene predicted gene, 46401 Neighboring gene STARR-seq mESC enhancer starr_33554 Neighboring gene STARR-seq mESC enhancer starr_33556 Neighboring gene STARR-seq mESC enhancer starr_33558 Neighboring gene predicted gene, 35615

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The zinc-finger transcription factor KLF6 regulates cardiac fibrosis. Li N, et al. Life Sci, 2024 Aug 15. PMID 38851422
  2. Krüppel-like factor 6 regulates mitochondrial function in the kidney. Mallipattu SK, et al. J Clin Invest, 2015 Mar 2. PMID 25689250, Free PMC Article
  3. Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. Trucco LD, et al. FASEB J, 2014 Dec. PMID 25212220
  4. Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury. Ghiassi-Nejad Z, et al. Hepatology, 2013 Feb. PMID 22961688, Free PMC Article
  5. Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. Tarocchi M, et al. Hepatology, 2011 Aug. PMID 21563203, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The zinc-finger transcription factor KLF6 regulates cardiac fibrosis.
    Title: The zinc-finger transcription factor KLF6 regulates cardiac fibrosis.
  2. miRNA-21 promotes the progression of acute liver failure via the KLF6/autophagy/IL-23 signaling pathway.
    Title: miRNA‑21 promotes the progression of acute liver failure via the KLF6/autophagy/IL‑23 signaling pathway.
  3. Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development.
    Title: Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development.
  4. MicroRNA-22-3p in human umbilical cord mesenchymal stem cell-secreted exosomes inhibits granulosa cell apoptosis by targeting KLF6 and ATF4-ATF3-CHOP pathway in POF mice.
    Title: MicroRNA-22-3p in human umbilical cord mesenchymal stem cell-secreted exosomes inhibits granulosa cell apoptosis by targeting KLF6 and ATF4-ATF3-CHOP pathway in POF mice.
  5. KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy.
    Title: KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy.
  6. Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.
    Title: Identification of KLF6/PSGs and NPY-Related USF2/CEACAM Transcriptional Regulatory Networks via Spinal Cord Bulk and Single-Cell RNA-Seq Analysis.
  7. Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
    Title: Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
  8. Kruppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.
    Title: Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.
  9. Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.
    Title: Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis.
  10. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.
    Title: Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of connective tissue replacement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Krueppel-like factor 6
Names
Kruppel-like factor 6
core promoter element binding protein
immediate early response, erythropoietin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011803.2 → NP_035933.2  Krueppel-like factor 6

    See identical proteins and their annotated locations for NP_035933.2

    Status: VALIDATED

    Source sequence(s)
    AK146615, BY128594
    Consensus CDS
    CCDS26229.1
    UniProtKB/TrEMBL
    Q3UGJ1, Q8BPQ2, Q8VDZ7
    Related
    ENSMUSP00000000080.7, ENSMUST00000000080.8
    Conserved Domains (4) summary
    COG5048
    Location:212 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:240 → 259
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:235 → 259
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:281 → 306
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    5911488..5920392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08584.3 GenPept UniProtKB/Swiss-Prot:O08584

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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