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NTSR2 neurotensin receptor 2 [ Homo sapiens (human) ]

Gene ID: 23620, updated on 2-Nov-2024

Summary

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Official Symbol
NTSR2provided by HGNC
Official Full Name
neurotensin receptor 2provided by HGNC
Primary source
HGNC:HGNC:8040
See related
Ensembl:ENSG00000169006 MIM:605538; AllianceGenome:HGNC:8040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTR2
Summary
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 9.3) See more
Orthologs
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Genomic context

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See NTSR2 in Genome Data Viewer
Location:
2p25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (11658178..11670195, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (11691322..11703339, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11798304..11810321, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11714607-11715107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11718473-11719108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11719109-11719744 Neighboring gene RNA, 5S ribosomal pseudogene 85 Neighboring gene Sharpr-MPRA regulatory region 7562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11175 Neighboring gene RNA, 7SL, cytoplasmic 674, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:11738736-11738940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11756351-11756851 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:11771171-11772370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11796533-11797486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11809762-11810298 Neighboring gene uncharacterized LOC100506405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11822031-11822671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11828037-11828536 Neighboring gene cyclin dependent kinase 8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11836720-11837568 Neighboring gene lipin 1 Neighboring gene uncharacterized LOC101929752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review). Yang Y, et al. Protein Pept Lett, 2024. PMID 37962046
  2. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Vita N, et al. Eur J Pharmacol, 1998 Nov 6. PMID 9851594
  3. Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes. Ramez M, et al. J Invest Dermatol, 2001 Sep. PMID 11564178
  4. Expression of neurotensin receptors in human corneal keratocytes. Bourcier T, et al. Invest Ophthalmol Vis Sci, 2002 Jun. PMID 12036977
  5. Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells. Leyton J, et al. Eur J Pharmacol, 2002 May 10. PMID 12065070

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
    Title: Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
  2. Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
    Title: Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
  3. Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
    Title: Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
  4. A novel role of NTS in the development of Castration-resistant prostate cancer with Neuroendocrine differentiation (NED), and a possible strategy to prevent the onset of NED by targeting the NTS signaling pathway.
    Title: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.
  5. High NTSR2 expression is associated with B-cell chronic lymphocytic leukemia.
    Title: Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis.
  6. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined.
    Title: Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.
  7. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells
    Title: Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
  8. NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells.
    Title: Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
  9. this study proposes a novel function of NTR2 in the regulation of NTR1 activity.
    Title: Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.
  10. NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+)
    Title: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled neurotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neurotensin receptor type 2
Names
NT-R-2
levocabastine-sensitive neurotensin receptor
neurotensin receptor, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012344.4 → NP_036476.2  neurotensin receptor type 2

    Status: REVIEWED

    Source sequence(s)
    AC106875, AC110754
    Consensus CDS
    CCDS1681.1
    UniProtKB/Swiss-Prot
    O95665, Q53QQ5, Q57Z87, Q8IY58, Q8TBH6
    Related
    ENSP00000303686.5, ENST00000306928.6
    Conserved Domains (1) summary
    cd15356
    Location:33 → 369
    7tmA_NTSR2; neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    11658178..11670195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246156.4 → XP_005246213.1  neurotensin receptor type 2 isoform X4

    Conserved Domains (1) summary
    pfam00001
    Location:98 → 182
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. XM_006711877.4 → XP_006711940.1  neurotensin receptor type 2 isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:35 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 233
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006711876.5 → XP_006711939.1  neurotensin receptor type 2 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:98 → 234
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. XM_017003738.2 → XP_016859227.1  neurotensin receptor type 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    11691322..11703339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341228.1 → XP_054197203.1  neurotensin receptor type 2 isoform X4

  2. XM_054341227.1 → XP_054197202.1  neurotensin receptor type 2 isoform X3

  3. XM_054341226.1 → XP_054197201.1  neurotensin receptor type 2 isoform X2

  4. XM_054341225.1 → XP_054197200.1  neurotensin receptor type 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95665.2 GenPept UniProtKB/Swiss-Prot:O95665

Gene LinkOut

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