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Edc4 enhancer of mRNA decapping 4 [ Mus musculus (house mouse) ]

Gene ID: 234699, updated on 2-Nov-2024

Summary

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Official Symbol
Edc4provided by MGI
Official Full Name
enhancer of mRNA decapping 4provided by MGI
Primary source
MGI:MGI:2446249
See related
Ensembl:ENSMUSG00000036270 AllianceGenome:MGI:2446249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in thymus adult (RPKM 38.7), ovary adult (RPKM 33.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Edc4 in Genome Data Viewer
Location:
8 D3; 8 53.05 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106607506..106619857)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105880873..105893225)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene THAP domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene nuclear transport factor 2 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene STARR-positive B cell enhancer ABC_E3800 Neighboring gene neuritin 1-like Neighboring gene protein serine kinase H1 Neighboring gene STARR-positive B cell enhancer ABC_E6679

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. Bloch DB, et al. Clin Immunol Immunopathol, 1994 Sep. PMID 7520377
  2. Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. Yu JH, et al. RNA, 2005 Dec. PMID 16314453, Free PMC Article
  3. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Glasmacher E, et al. Nat Immunol, 2010 Aug. PMID 20639877
  4. CCHCR1 interacts with EDC4, suggesting its localization in P-bodies. Ling YH, et al. Exp Cell Res, 2014 Sep 10. PMID 24858563
  5. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. Unhavaithaya Y, et al. J Biol Chem, 2009 Mar 6. PMID 19114715, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enhancer of mRNA-decapping protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301100.2 → NP_001288029.1  enhancer of mRNA-decapping protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001288029.1

    Status: REVIEWED

    Source sequence(s)
    AC159265
    Consensus CDS
    CCDS80923.1
    UniProtKB/Swiss-Prot
    Q3U6U8, Q3UJB9, Q7TS78, Q8R223
    UniProtKB/TrEMBL
    G5E896
    Related
    ENSMUSP00000039134.10, ENSMUST00000040254.16
    Conserved Domains (3) summary
    pfam16529
    Location:114 → 440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304 → 343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001404070.1 → NP_001390999.1  enhancer of mRNA-decapping protein 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC159265

  3. NM_001404071.1 → NP_001391000.1  enhancer of mRNA-decapping protein 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC159265

  4. NM_001404072.1 → NP_001391001.1  enhancer of mRNA-decapping protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC159265

  5. NM_001404073.1 → NP_001391002.1  enhancer of mRNA-decapping protein 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC159265

  6. NM_001404074.1 → NP_001391003.1  enhancer of mRNA-decapping protein 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC159265

  7. NM_181594.4 → NP_853625.1  enhancer of mRNA-decapping protein 4 isoform 2

    See identical proteins and their annotated locations for NP_853625.1

    Status: REVIEWED

    Source sequence(s)
    AC159265
    Consensus CDS
    CCDS52662.1
    UniProtKB/Swiss-Prot
    Q3U6U8, Q3UJB9, Q7TS78, Q8R223
    UniProtKB/TrEMBL
    A0A0R4J1Q0
    Related
    ENSMUSP00000113854.2, ENSMUST00000119261.8
    Conserved Domains (3) summary
    pfam16529
    Location:114 → 440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
    sd00039
    Location:304 → 343
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:260 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106607506..106619857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312743.2 → XP_017168232.1  enhancer of mRNA-decapping protein 4 isoform X3

    UniProtKB/Swiss-Prot
    Q3U6U8, Q3UJB9, Q7TS78, Q8R223
    Conserved Domains (2) summary
    sd00039
    Location:304 → 343
    7WD40; WD40 repeat [structural motif]
    pfam16529
    Location:114 → 440
    Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein

  2. XM_006530905.4 → XP_006530968.1  enhancer of mRNA-decapping protein 4 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UJB9.2 GenPept UniProtKB/Swiss-Prot:Q3UJB9

Gene LinkOut

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