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Sorbs2 sorbin and SH3 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 234214, updated on 2-Nov-2024

Summary

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Official Symbol
Sorbs2provided by MGI
Official Full Name
sorbin and SH3 domain containing 2provided by MGI
Primary source
MGI:MGI:1924574
See related
Ensembl:ENSMUSG00000031626 AllianceGenome:MGI:1924574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Argbp2; nArgBP2; mKIAA0777; A530071H08; 2010203O03Rik; 9430041O17Rik
Summary
Enables protein domain specific binding activity. Acts upstream of or within Notch signaling pathway; acetylcholine receptor signaling pathway; and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in plasma membrane and synapse. Is expressed in several structures, including brain; cardiovascular system; cranium; foot bone; and foregut. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 23.2), cortex adult (RPKM 14.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Sorbs2 in Genome Data Viewer
Location:
8 B1.1; 8 25.44 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45960470..46280943)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45507788..45827906)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30504 Neighboring gene family with sequence similarity 149, member A Neighboring gene STARR-seq mESC enhancer starr_21371 Neighboring gene toll-like receptor 3 Neighboring gene predicted gene, 30759 Neighboring gene predicted gene 16351 Neighboring gene predicted gene, 23604 Neighboring gene predicted gene, 51529 Neighboring gene STARR-seq mESC enhancer starr_21373 Neighboring gene predicted gene, 30635 Neighboring gene sorbin and SH3 domain containing 2, opposite strand Neighboring gene predicted gene, 25309 Neighboring gene PDZ and LIM domain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes. Sun X, et al. Circ Res, 2024 Mar 29. PMID 38362769,
  2. nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders. Lee SE, et al. BMB Rep, 2016 Sep. PMID 27530683, Free PMC Article
  3. Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2. Qian LL, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Dec 1. PMID 34487812, Free PMC Article
  4. Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. McLendon JM, et al. J Am Heart Assoc, 2022 Jul 5. PMID 35730644, Free PMC Article
  5. The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease. Li C, et al. Aging (Albany NY), 2022 Jan 20. PMID 35050860, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
    Title: Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
  2. Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes.
    Title: Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes.
  3. MiR-484 promotes nonalcoholic fatty liver disease progression in mice via downregulation of Sorbs2.
    Title: MiR-484 promotes nonalcoholic fatty liver disease progression in mice via downregulation of Sorbs2.
  4. Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.
    Title: Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.
  5. The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease.
    Title: The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease.
  6. Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2.
    Title: Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2.
  7. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
    Title: Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
  8. the present study provides strong evidence that miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. Inhibition of miR-21-3p might be a protective strategy to treat sepsis-induced cardiac dysfunction.
    Title: miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2.
  9. The nArgBP2 binds to the two most prominent postsynaptic proteins that are associated with various mood disorders, we propose that nArgBP2could function as a hub able to link together etiological factors of different disorders.
    Title: nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders.
  10. The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
    Title: Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2010203O03Rik, 9430041O17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within acetylcholine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sorbin and SH3 domain-containing protein 2
Names
Arg/Abl-binding protein 2
Arg/Abl-interacting protein ArgBP2
arg-binding protein 2
arg/Abl-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205219.1 → NP_001192148.1  sorbin and SH3 domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001192148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113469, AC116747, AC116861
    Consensus CDS
    CCDS57618.1
    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    UniProtKB/TrEMBL
    B9EKP8
    Related
    ENSMUSP00000128000.3, ENSMUST00000171337.10
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1154 → 1214
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:980 → 1034
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1055 → 1111
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  2. NM_001310707.1 → NP_001297636.1  sorbin and SH3 domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences but maintains the reading frame compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC113469, AK041051, AK050951, AK083429, AK140498, BB609472, BC157944, BE862797, CN535874
    Consensus CDS
    CCDS80872.1
    UniProtKB/TrEMBL
    D3Z080
    Related
    ENSMUSP00000123250.2, ENSMUST00000132139.9
    Conserved Domains (3) summary
    smart00459
    Location:144 → 194
    Sorb; Sorbin homologous domain
    cd11923
    Location:558 → 614
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:483 → 537
    SH3; Src Homology 3 domain superfamily

  3. NM_001310708.1 → NP_001297637.1  sorbin and SH3 domain-containing protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001297637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences but maintains the reading frame compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC113469, AC116747, BC157944, BE862797
    Consensus CDS
    CCDS80874.1
    UniProtKB/TrEMBL
    B2RXQ9
    Related
    ENSMUSP00000121619.2, ENSMUST00000130011.8
    Conserved Domains (4) summary
    cd11923
    Location:493 → 549
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:232 → 374
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02208
    Location:116 → 157
    Sorb; Sorbin homologous domain
    cl17036
    Location:592 → 652
    SH3; Src Homology 3 domain superfamily

  4. NM_001402663.1 → NP_001389592.1  sorbin and SH3 domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  5. NM_001402664.1 → NP_001389593.1  sorbin and SH3 domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747

  6. NM_001402665.1 → NP_001389594.1  sorbin and SH3 domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747

  7. NM_001402666.1 → NP_001389595.1  sorbin and SH3 domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  8. NM_001402667.1 → NP_001389596.1  sorbin and SH3 domain-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  9. NM_001402668.1 → NP_001389597.1  sorbin and SH3 domain-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  10. NM_001402669.1 → NP_001389598.1  sorbin and SH3 domain-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  11. NM_001402670.1 → NP_001389599.1  sorbin and SH3 domain-containing protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747
    UniProtKB/TrEMBL
    A0A1L7NR37

  12. NM_001402671.1 → NP_001389600.1  sorbin and SH3 domain-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  13. NM_001402672.1 → NP_001389601.1  sorbin and SH3 domain-containing protein 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC116861

  14. NM_001402673.1 → NP_001389602.1  sorbin and SH3 domain-containing protein 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351

  15. NM_001402674.1 → NP_001389603.1  sorbin and SH3 domain-containing protein 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747, AC158351
    UniProtKB/TrEMBL
    A0A0R4J1W0

  16. NM_001402675.1 → NP_001389604.1  sorbin and SH3 domain-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC113469, AC116747

  17. NM_172752.4 → NP_766340.4  sorbin and SH3 domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_766340.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC113469, AC116747, AC116861
    Consensus CDS
    CCDS57619.1
    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    UniProtKB/TrEMBL
    B7ZWM6, E9Q0B0
    Related
    ENSMUSP00000067641.8, ENSMUST00000067107.15
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1136 → 1196
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:962 → 1016
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1037 → 1093
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    45960470..46280943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153896.1 → XP_036009789.1  sorbin and SH3 domain-containing protein 2 isoform X10

    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    Conserved Domains (4) summary
    cd11920
    Location:995 → 1049
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1070 → 1126
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:147 → 188
    Sorb; Sorbin homologous domain
    cl17036
    Location:1169 → 1219
    SH3; Src Homology 3 domain superfamily

  2. XM_030243439.2 → XP_030099299.1  sorbin and SH3 domain-containing protein 2 isoform X29

    Conserved Domains (3) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11923
    Location:582 → 638
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:681 → 741
    SH3; Src Homology 3 domain superfamily

  3. XM_036153910.1 → XP_036009803.1  sorbin and SH3 domain-containing protein 2 isoform X36

    Conserved Domains (3) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11923
    Location:509 → 565
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:608 → 668
    SH3; Src Homology 3 domain superfamily

  4. XM_036153905.1 → XP_036009798.1  sorbin and SH3 domain-containing protein 2 isoform X28

    Conserved Domains (3) summary
    smart00459
    Location:144 → 194
    Sorb; Sorbin homologous domain
    cd11923
    Location:586 → 642
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:685 → 745
    SH3; Src Homology 3 domain superfamily

  5. XM_036153909.1 → XP_036009802.1  sorbin and SH3 domain-containing protein 2 isoform X35

    Conserved Domains (4) summary
    cd11923
    Location:524 → 580
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:263 → 405
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02208
    Location:147 → 188
    Sorb; Sorbin homologous domain
    cl17036
    Location:449 → 503
    SH3; Src Homology 3 domain superfamily

  6. XM_036153911.1 → XP_036009804.1  sorbin and SH3 domain-containing protein 2 isoform X38

    Conserved Domains (3) summary
    smart00459
    Location:136 → 186
    Sorb; Sorbin homologous domain
    cd11923
    Location:479 → 535
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:578 → 638
    SH3; Src Homology 3 domain superfamily

  7. XM_017312696.2 → XP_017168185.1  sorbin and SH3 domain-containing protein 2 isoform X41

    Conserved Domains (3) summary
    smart00459
    Location:113 → 163
    Sorb; Sorbin homologous domain
    cd11923
    Location:456 → 512
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:555 → 615
    SH3; Src Homology 3 domain superfamily

  8. XM_006509385.1 → XP_006509448.1  sorbin and SH3 domain-containing protein 2 isoform X39

    Related
    ENSMUSP00000118353.2, ENSMUST00000153798.8
    Conserved Domains (3) summary
    smart00459
    Location:136 → 186
    Sorb; Sorbin homologous domain
    cd11923
    Location:478 → 534
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:577 → 637
    SH3; Src Homology 3 domain superfamily

  9. XM_036153912.1 → XP_036009805.1  sorbin and SH3 domain-containing protein 2 isoform X40

    UniProtKB/TrEMBL
    A0A0R4J1W0
    Related
    ENSMUSP00000121235.2, ENSMUST00000139869.8
    Conserved Domains (3) summary
    cd11923
    Location:464 → 520
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:139 → 180
    Sorb; Sorbin homologous domain
    cl17036
    Location:563 → 623
    SH3; Src Homology 3 domain superfamily

  10. XM_011242198.1 → XP_011240500.1  sorbin and SH3 domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11917
    Location:1441 → 1501
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1267 → 1321
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1342 → 1398
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  11. XM_011242200.1 → XP_011240502.1  sorbin and SH3 domain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11920
    Location:1267 → 1321
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1342 → 1398
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:1441 → 1491
    SH3; Src Homology 3 domain superfamily

  12. XM_011242199.1 → XP_011240501.1  sorbin and SH3 domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11917
    Location:1440 → 1500
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1266 → 1320
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1341 → 1397
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  13. XM_011242201.1 → XP_011240503.1  sorbin and SH3 domain-containing protein 2 isoform X4

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11920
    Location:1266 → 1320
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1341 → 1397
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:1440 → 1490
    SH3; Src Homology 3 domain superfamily

  14. XM_036153897.1 → XP_036009790.1  sorbin and SH3 domain-containing protein 2 isoform X11

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11920
    Location:740 → 794
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:815 → 871
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:914 → 974
    SH3; Src Homology 3 domain superfamily

  15. XM_011242205.1 → XP_011240507.1  sorbin and SH3 domain-containing protein 2 isoform X12

    Conserved Domains (3) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11923
    Location:814 → 870
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:913 → 973
    SH3; Src Homology 3 domain superfamily

  16. XM_030243433.1 → XP_030099293.1  sorbin and SH3 domain-containing protein 2 isoform X13

    Conserved Domains (3) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11923
    Location:814 → 870
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:739 → 793
    SH3; Src Homology 3 domain superfamily

  17. XM_011242206.1 → XP_011240508.1  sorbin and SH3 domain-containing protein 2 isoform X15

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11923
    Location:786 → 842
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:543 → 706
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17036
    Location:885 → 945
    SH3; Src Homology 3 domain superfamily

  18. XM_030243435.1 → XP_030099295.1  sorbin and SH3 domain-containing protein 2 isoform X16

    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11923
    Location:786 → 842
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:543 → 706
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17036
    Location:711 → 765
    SH3; Src Homology 3 domain superfamily

  19. XM_017312691.1 → XP_017168180.1  sorbin and SH3 domain-containing protein 2 isoform X17

    Conserved Domains (5) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11920
    Location:692 → 746
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:767 → 823
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:506 → 648
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17036
    Location:866 → 916
    SH3; Src Homology 3 domain superfamily

  20. XM_011242202.1 → XP_011240504.1  sorbin and SH3 domain-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    Conserved Domains (4) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11917
    Location:1340 → 1400
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1166 → 1220
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1241 → 1297
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  21. XM_030243437.1 → XP_030099297.1  sorbin and SH3 domain-containing protein 2 isoform X22

    Conserved Domains (3) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11923
    Location:715 → 771
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:814 → 874
    SH3; Src Homology 3 domain superfamily

  22. XM_030243438.1 → XP_030099298.1  sorbin and SH3 domain-containing protein 2 isoform X23

    Conserved Domains (3) summary
    smart00459
    Location:372 → 422
    Sorb; Sorbin homologous domain
    cd11923
    Location:714 → 770
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl17036
    Location:813 → 873
    SH3; Src Homology 3 domain superfamily

  23. XM_036153903.1 → XP_036009796.1  sorbin and SH3 domain-containing protein 2 isoform X24

    Conserved Domains (4) summary
    cd11920
    Location:625 → 679
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:700 → 756
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:375 → 416
    Sorb; Sorbin homologous domain
    cl17036
    Location:799 → 859
    SH3; Src Homology 3 domain superfamily

  24. XM_036153895.1 → XP_036009788.1  sorbin and SH3 domain-containing protein 2 isoform X6

    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1207 → 1267
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1033 → 1087
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1108 → 1164
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  25. XM_011242207.1 → XP_011240509.1  sorbin and SH3 domain-containing protein 2 isoform X25

    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11923
    Location:581 → 637
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:345 → 507
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17036
    Location:680 → 740
    SH3; Src Homology 3 domain superfamily

  26. XM_011242204.1 → XP_011240506.1  sorbin and SH3 domain-containing protein 2 isoform X8

    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1135 → 1195
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:961 → 1015
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1036 → 1092
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  27. XM_017312692.1 → XP_017168181.1  sorbin and SH3 domain-containing protein 2 isoform X27

    Conserved Domains (4) summary
    smart00459
    Location:167 → 212
    Sorb; Sorbin homologous domain
    cd11923
    Location:547 → 603
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:286 → 428
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17036
    Location:646 → 706
    SH3; Src Homology 3 domain superfamily

  28. XM_017312687.1 → XP_017168176.1  sorbin and SH3 domain-containing protein 2 isoform X7

    UniProtKB/Swiss-Prot
    Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0
    UniProtKB/TrEMBL
    A0A0S3CWK3
    Related
    ENSMUSP00000070720.8, ENSMUST00000067065.14
    Conserved Domains (4) summary
    smart00459
    Location:144 → 189
    Sorb; Sorbin homologous domain
    cd11917
    Location:1197 → 1257
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:1023 → 1077
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1098 → 1154
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  29. XM_011242209.1 → XP_011240511.1  sorbin and SH3 domain-containing protein 2 isoform X31

    Conserved Domains (4) summary
    smart00459
    Location:144 → 189
    Sorb; Sorbin homologous domain
    cd11923
    Location:524 → 580
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    PHA03307
    Location:263 → 405
    PHA03307; transcriptional regulator ICP4; Provisional
    cl17036
    Location:623 → 683
    SH3; Src Homology 3 domain superfamily

  30. XM_030243443.1 → XP_030099303.1  sorbin and SH3 domain-containing protein 2 isoform X43

    Conserved Domains (3) summary
    cd11923
    Location:329 → 385
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:4 → 36
    Sorb; Sorbin homologous domain
    cl17036
    Location:254 → 308
    SH3; Src Homology 3 domain superfamily

  31. XM_006509387.1 → XP_006509450.1  sorbin and SH3 domain-containing protein 2 isoform X42

    Conserved Domains (3) summary
    cd11923
    Location:328 → 384
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:4 → 36
    Sorb; Sorbin homologous domain
    cl17036
    Location:427 → 487
    SH3; Src Homology 3 domain superfamily

  32. XM_030243444.1 → XP_030099304.1  sorbin and SH3 domain-containing protein 2 isoform X44

    Conserved Domains (3) summary
    cd11923
    Location:328 → 384
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:4 → 36
    Sorb; Sorbin homologous domain
    cl17036
    Location:253 → 307
    SH3; Src Homology 3 domain superfamily

  33. XM_006509375.1 → XP_006509438.1  sorbin and SH3 domain-containing protein 2 isoform X14

    UniProtKB/TrEMBL
    Z4YJR7
    Conserved Domains (4) summary
    cd11917
    Location:939 → 999
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:840 → 896
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cl02617
    Location:4 → 31
    Sorb; Sorbin homologous domain
    cl17036
    Location:765 → 819
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UTJ2.2 GenPept UniProtKB/Swiss-Prot:Q3UTJ2

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