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Hipk4 homeodomain interacting protein kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 233020, updated on 30-Apr-2024

Summary

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Official Symbol
Hipk4provided by MGI
Official Full Name
homeodomain interacting protein kinase 4provided by MGI
Primary source
MGI:MGI:2685008
See related
Ensembl:ENSMUSG00000040424 AllianceGenome:MGI:2685008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm162
Summary
Enables protein kinase activity. Acts upstream of or within protein phosphorylation and regulation of signal transduction by p53 class mediator. Located in cytoplasm and nucleus. Is expressed in alimentary system; brain; and genitourinary system. Orthologous to human HIPK4 (homeodomain interacting protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 53.4), cortex adult (RPKM 14.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Hipk4 in Genome Data Viewer
Location:
7 A3; 7 15.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27222686..27230605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27523261..27531180)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E107 Neighboring gene SERTA domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4910 Neighboring gene predicted gene 15541 Neighboring gene periaxin Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28326448-28326635 Neighboring gene phospholipase D family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28330144-28330331 Neighboring gene RIKEN cDNA 2310022A10 gene Neighboring gene predicted gene, 45975

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. Arai S, et al. FEBS Lett, 2007 Dec 11. PMID 18022393
  2. HIPK4 is essential for murine spermiogenesis. Crapster JA, et al. Elife, 2020 Mar 12. PMID 32163033, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
homeodomain-interacting protein kinase 4
NP_001028487.2
XP_011248824.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033315.2 → NP_001028487.2  homeodomain-interacting protein kinase 4

    See identical proteins and their annotated locations for NP_001028487.2

    Status: VALIDATED

    Source sequence(s)
    AB354583, AC158304, BY084855, CB248531, CJ235960, CR521665
    Consensus CDS
    CCDS21024.2
    UniProtKB/Swiss-Prot
    A8R3X8, B9EJV5, Q3V016
    Related
    ENSMUSP00000103990.3, ENSMUST00000108353.9
    Conserved Domains (1) summary
    cl21453
    Location:11 → 347
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27222686..27230605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250522.3 → XP_011248824.1  homeodomain-interacting protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_011248824.1

    UniProtKB/Swiss-Prot
    Q3V016
    Related
    ENSMUSP00000043175.7, ENSMUST00000037134.7
    Conserved Domains (1) summary
    cl21453
    Location:1 → 143
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V016.2 GenPept UniProtKB/Swiss-Prot:Q3V016

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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