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XPO6 exportin 6 [ Homo sapiens (human) ]

Gene ID: 23214, updated on 2-Nov-2024

Summary

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Official Symbol
XPO6provided by HGNC
Official Full Name
exportin 6provided by HGNC
Primary source
HGNC:HGNC:19733
See related
Ensembl:ENSG00000169180 MIM:608411; AllianceGenome:HGNC:19733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EXP6; RANBP20
Summary
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 30.3), spleen (RPKM 24.2) and 25 other tissues See more
Orthologs
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Genomic context

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See XPO6 in Genome Data Viewer
Location:
16p12.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28097976..28211965, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28378417..28492441, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28109297..28223286, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene GSG1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27878335-27878836 Neighboring gene RNA, U6 small nuclear 159, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:27960751-27960921 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:28004462-28005661 Neighboring gene RNA, U6 small nuclear 1241, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:28030002-28031201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28037919-28038419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28102727-28103678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28108651-28109150 Neighboring gene uncharacterized LOC124903669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10636 Neighboring gene NANOG hESC enhancer GRCh37_chr16:28157890-28158405 Neighboring gene TP53RK binding protein pseudogene 2 Neighboring gene uncharacterized LOC124900376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7305 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28203444-28203616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10639 Neighboring gene Sharpr-MPRA regulatory region 6679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28222406-28223404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28230517-28231018 Neighboring gene RNY1 pseudogene 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28234253-28235103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28271835-28272335 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 35 Neighboring gene Sharpr-MPRA regulatory region 11993 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene SH3 domain binding kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evolution of the karyopherin-β family of nucleocytoplasmic transport factors; ancient origins and continued specialization. O'Reilly AJ, et al. PLoS One, 2011 Apr 27. PMID 21556326, Free PMC Article
  2. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Ambs S, et al. Cancer Res, 2008 Aug 1. PMID 18676839, Free PMC Article
  3. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. Suzuki T, et al. Biomed Res, 2008 Jun. PMID 18614847
  4. Elevated XPO6 expression as a potential prognostic biomarker for prostate cancer recurrence. Hao J, et al. Front Biosci (Schol Ed), 2016 Jan 1. PMID 26709895
  5. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Suzuki T, et al. Biomed Res, 2006 Jun. PMID 16847355

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.
    Title: Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.
  2. The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear Release Late in Infection.
    Title: The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear Release Late in Infection.
  3. These results shed light on the crucial role of LN1 in quiescence and differentiation and how defects in the LN1/PI3K/XPO6/N-actin axis explain the loss of tissue homeostasis and growth control that contributes to malignant progression.
    Title: Laminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6.
  4. potential prognostic biomarker for predicting prostate cancer recurrence [meta-analysis]
    Title: Elevated XPO6 expression as a potential prognostic biomarker for prostate cancer recurrence.
  5. Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation.
    Title: Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes
    Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22519, KIAA0370

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
exportin-6
Names
ran-binding protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270940.2 → NP_001257869.1  exportin-6 isoform 1

    See identical proteins and their annotated locations for NP_001257869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform (1).
    Source sequence(s)
    AB002368, AC136611, AK026172, AK123846, AY026388, BI465054, BX346769
    Consensus CDS
    CCDS59266.1
    UniProtKB/TrEMBL
    B3KW08
    Related
    ENSP00000457341.1, ENST00000565698.5
    Conserved Domains (2) summary
    smart00913
    Location:17 → 82
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:89 → 263
    Xpo1; Exportin 1-like protein

  2. NM_015171.4 → NP_055986.1  exportin-6 isoform 2

    See identical proteins and their annotated locations for NP_055986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AB002368, AC136611, AK026172, AY026388, BI465054, BX346769
    Consensus CDS
    CCDS42135.1
    UniProtKB/Swiss-Prot
    A1L3W4, D3DWF9, Q2YDX3, Q53G88, Q68G50, Q76N88, Q96CP8, Q96QU8, Q9BT21
    UniProtKB/TrEMBL
    B7ZM10
    Related
    ENSP00000302790.4, ENST00000304658.10
    Conserved Domains (2) summary
    smart00913
    Location:31 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103 → 253
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28097976..28211965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28378417..28492441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QU8.1 GenPept UniProtKB/Swiss-Prot:Q96QU8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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