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Cdh19 cadherin 19, type 2 [ Mus musculus (house mouse) ]

Gene ID: 227485, updated on 2-Nov-2024

Summary

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Official Symbol
Cdh19provided by MGI
Official Full Name
cadherin 19, type 2provided by MGI
Primary source
MGI:MGI:3588198
See related
Ensembl:ENSMUSG00000047216 AllianceGenome:MGI:3588198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human CDH19 (cadherin 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 1.4), frontal lobe adult (RPKM 1.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Cdh19 in Genome Data Viewer
Location:
1 E2.1; 1 50.78 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (110811802..110905331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (110888002..110977601, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 64 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01890 Neighboring gene STARR-seq mESC enhancer starr_01891 Neighboring gene AMME chromosomal region gene 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_01892 Neighboring gene STARR-seq mESC enhancer starr_01893 Neighboring gene STARR-seq mESC enhancer starr_01894 Neighboring gene STARR-seq mESC enhancer starr_01895 Neighboring gene STARR-seq mESC enhancer starr_01896 Neighboring gene STARR-seq mESC enhancer starr_01897 Neighboring gene nuclear encoded tRNA lysine 7 (anticodon CTT) Neighboring gene RIKEN cDNA 4921525D07 gene Neighboring gene STARR-seq mESC enhancer starr_01898 Neighboring gene STARR-seq mESC enhancer starr_01899 Neighboring gene STARR-seq mESC enhancer starr_01901 Neighboring gene STARR-seq mESC enhancer starr_01902 Neighboring gene STARR-seq mESC enhancer starr_01903 Neighboring gene STARR-seq mESC enhancer starr_01904 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects. Huang T, et al. Gastroenterology, 2022 Jan. PMID 34425092
  2. Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest. Espinosa-Medina I, et al. Proc Natl Acad Sci U S A, 2017 Nov 7. PMID 29078343, Free PMC Article
  3. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
  4. Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Espinosa-Medina I, et al. Science, 2014 Jul 4. PMID 24925912
  5. Phrenic-specific transcriptional programs shape respiratory motor output. Vagnozzi AN, et al. Elife, 2020 Jan 16. PMID 31944180, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects.
    Title: Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cadherin-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081386.2 → NP_001074855.1  cadherin-19

    See identical proteins and their annotated locations for NP_001074855.1

    Status: VALIDATED

    Source sequence(s)
    AC101787, AC162899
    Consensus CDS
    CCDS35687.1
    UniProtKB/TrEMBL
    B2RXP4, E9Q3A7
    Related
    ENSMUSP00000092210.4, ENSMUST00000094626.5
    Conserved Domains (2) summary
    cd11304
    Location:150 → 250
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:617 → 764
    Cadherin_C; Cadherin cytoplasmic region

  2. NM_001356415.1 → NP_001343344.1  cadherin-19

    Status: VALIDATED

    Source sequence(s)
    AC101787, AC162899
    Consensus CDS
    CCDS35687.1
    UniProtKB/TrEMBL
    B2RXP4, E9Q3A7
    Conserved Domains (2) summary
    cd11304
    Location:150 → 250
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:617 → 764
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    110811802..110905331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247991.3 → XP_011246293.1  cadherin-19 isoform X2

    UniProtKB/TrEMBL
    B2RXP4
    Conserved Domains (2) summary
    cd11304
    Location:95 → 195
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:562 → 709
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_036164614.1 → XP_036020507.1  cadherin-19 isoform X1

    UniProtKB/TrEMBL
    B2RXP4, E9Q3A7
    Conserved Domains (2) summary
    cd11304
    Location:150 → 250
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:617 → 764
    Cadherin_C; Cadherin cytoplasmic region

  3. XM_036164615.1 → XP_036020508.1  cadherin-19 isoform X3

    Conserved Domains (2) summary
    cd11304
    Location:2 → 93
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:460 → 607
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version

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