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Mark1 MAP/microtubule affinity regulating kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 226778, updated on 2-Nov-2024

Summary

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Official Symbol
Mark1provided by MGI
Official Full Name
MAP/microtubule affinity regulating kinase 1provided by MGI
Primary source
MGI:MGI:2664902
See related
Ensembl:ENSMUSG00000026620 AllianceGenome:MGI:2664902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emk3; Par-1c; mPar-1c; mKIAA1477; B930025N23Rik
Summary
Predicted to enable several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in establishment of mitochondrion localization; regulation of dendrite development; and regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human MARK1 (microtubule affinity regulating kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 14.7), whole brain E14.5 (RPKM 14.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Mark1 in Genome Data Viewer
Location:
1 H5; 1 89.26 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184628621..184732152, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184896424..184999954, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130074G19 gene Neighboring gene predicted gene, 34602 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 39728 Neighboring gene STARR-seq mESC enhancer starr_03320 Neighboring gene predicted gene, 34732 Neighboring gene STARR-seq mESC enhancer starr_03321 Neighboring gene predicted gene, 37662 Neighboring gene predicted gene, 34797

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo. Kelly-Castro EC, et al. Exp Neurol, 2024 Jun. PMID 38484863
  2. Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development. Fumoto K, et al. J Cell Sci, 2019 Dec 13. PMID 31719161
  3. DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants. Kwan V, et al. Cell Rep, 2016 Nov 8. PMID 27829159
  4. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Maussion G, et al. Hum Mol Genet, 2008 Aug 15. PMID 18492799
  5. Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate. Krumova P, et al. FASEB J, 2015 Jul. PMID 25854701

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo.
    Title: MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo.
  2. The results suggest that Mark1-mediated fibroblast activation induces AECI flattening and thereby regulates distal lung sacculation.
    Title: Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development.
  3. In vitro kinase assays and metabolic-labeling experiments in living cells confirmed MARK1 as an LRRK2 substrate. Moreover, we also showed that LRRK2 and MARK1 are interacting in eukaryotic cells.
    Title: Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.
  4. Overexpression and silencing of MARK1 resulted in significantly shorter dendrite length in mouse neocortical neurons and modified dendritic transport speed.
    Title: Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1477

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase MARK1
Names
ELKL motif serine-threonine protein kinase 3
PAR1 homolog c
NP_001365805.1
NP_663490.2
XP_006497203.1
XP_006497204.1
XP_030109398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378876.1 → NP_001365805.1  serine/threonine-protein kinase MARK1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117826, AC131992
    UniProtKB/TrEMBL
    C9K101
    Conserved Domains (3) summary
    cd12196
    Location:697 → 794
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59 → 311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331 → 371
    UBA_like_SF; UBA domain-like superfamily

  2. NM_145515.2 → NP_663490.2  serine/threonine-protein kinase MARK1 isoform 2

    See identical proteins and their annotated locations for NP_663490.2

    Status: VALIDATED

    Source sequence(s)
    AC131992, AK047140, AK173181, BC112400, CJ179387, CX210969
    Consensus CDS
    CCDS35817.1
    UniProtKB/Swiss-Prot
    E9QL17, Q69ZI7, Q8VHJ5
    UniProtKB/TrEMBL
    Q14DQ3
    Related
    ENSMUSP00000027929.5, ENSMUST00000027929.10
    Conserved Domains (3) summary
    cd12196
    Location:696 → 793
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59 → 311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331 → 371
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    184628621..184732152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497140.5 → XP_006497203.1  serine/threonine-protein kinase MARK1 isoform X1

    UniProtKB/TrEMBL
    C9K101
    Conserved Domains (3) summary
    cd12196
    Location:682 → 779
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59 → 311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331 → 371
    UBA_like_SF; UBA domain-like superfamily

  2. XM_030253538.1 → XP_030109398.1  serine/threonine-protein kinase MARK1 isoform X3

    Conserved Domains (3) summary
    cd12196
    Location:417 → 514
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cl21453
    Location:1 → 32
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:52 → 92
    UBA_like_SF; UBA domain-like superfamily

  3. XM_006497141.5 → XP_006497204.1  serine/threonine-protein kinase MARK1 isoform X2

    UniProtKB/TrEMBL
    Q14DQ3
    Conserved Domains (3) summary
    cd12196
    Location:681 → 778
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59 → 311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331 → 371
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHJ5.2 GenPept UniProtKB/Swiss-Prot:Q8VHJ5

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