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Wbp4 WW domain binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 22380, updated on 2-Nov-2024

Summary

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Official Symbol
Wbp4provided by MGI
Official Full Name
WW domain binding protein 4provided by MGI
Primary source
MGI:MGI:109568
See related
Ensembl:ENSMUSG00000022023 AllianceGenome:MGI:109568
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP21
Summary
Predicted to enable RNA binding activity and proline-rich region binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Part of spliceosomal complex. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human WBP4 (WW domain binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.8), CNS E18 (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wbp4 in Genome Data Viewer
Location:
14 D3; 14 42.66 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79697377..79718708, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79459937..79481268, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mitochondrial translational release factor 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon TTC) Neighboring gene E74 like ETS transcription factor 1 Neighboring gene claspin homolog pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:79915269-79915570 Neighboring gene STARR-positive B cell enhancer ABC_E9411

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Yadav N, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12756295, Free PMC Article
  2. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article
  3. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. Chan DC, et al. EMBO J, 1996 Mar 1. PMID 8605874, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WW domain-binding protein 4
Names
WBP-4
WW domain-containing-binding protein 4
formin binding protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018765.3 → NP_061235.2  WW domain-binding protein 4

    See identical proteins and their annotated locations for NP_061235.2

    Status: PROVISIONAL

    Source sequence(s)
    AC151994
    Consensus CDS
    CCDS27300.1
    UniProtKB/Swiss-Prot
    Q3TUU8, Q61048, Q8K1Z9, Q9CS45
    UniProtKB/TrEMBL
    Q3TWW5
    Related
    ENSMUSP00000022601.6, ENSMUST00000022601.7
    Conserved Domains (2) summary
    COG5104
    Location:129 → 195
    PRP40; Splicing factor [RNA processing and modification]
    pfam06220
    Location:8 → 44
    zf-U1; U1 zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    79697377..79718708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61048.4 GenPept UniProtKB/Swiss-Prot:Q61048

Gene LinkOut

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