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Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) [ Mus musculus (house mouse) ]

Gene ID: 22228, updated on 2-Nov-2024

Summary

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Official Symbol
Ucp2provided by MGI
Official Full Name
uncoupling protein 2 (mitochondrial, proton carrier)provided by MGI
Primary source
MGI:MGI:109354
See related
Ensembl:ENSMUSG00000033685 AllianceGenome:MGI:109354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCPH; UCP 2; Slc25a8
Summary
Enables GDP binding activity. Involved in several processes, including cellular response to glucose stimulus; macrophage differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in stomach adult (RPKM 802.8), duodenum adult (RPKM 693.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Ucp2 in Genome Data Viewer
Location:
7 E2; 7 54.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100142565..100148832)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100493337..100499629)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene predicted gene 10603 Neighboring gene uncoupling protein 3 (mitochondrial, proton carrier) Neighboring gene STARR-positive B cell enhancer mm9_chr7:107641658-107641958 Neighboring gene STARR-positive B cell enhancer ABC_E2244 Neighboring gene STARR-seq mESC enhancer starr_19669 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene predicted gene, 39058

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. Joseph JW, et al. J Biol Chem, 2004 Dec 3. PMID 15448158
  2. Increased GLP-1 response after gavage-administration of glucose in UCP2-deficient mice. Zhang H, et al. Horm Metab Res, 2012 Feb. PMID 22198816
  3. UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Diao J, et al. Proc Natl Acad Sci U S A, 2008 Aug 19. PMID 18701716, Free PMC Article
  4. UCP2 knockout suppresses mouse skin carcinogenesis. Li W, et al. Cancer Prev Res (Phila), 2015 Jun. PMID 25784177, Free PMC Article
  5. Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia. Haslip M, et al. Arterioscler Thromb Vasc Biol, 2015 May. PMID 25814675, Free PMC Article

See all (309) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uncoupling Protein 2 Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis.
    Title: Uncoupling Protein 2 Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis.
  2. Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2.
    Title: Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2.
  3. Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent proteolytic processing of OPA1 in podocytes.
    Title: Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent proteolytic processing of OPA1 in podocytes.
  4. UCP2 deficiency impairs podocyte autophagy in diabetic nephropathy.
    Title: UCP2 deficiency impairs podocyte autophagy in diabetic nephropathy.
  5. AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo.
    Title: AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo.
  6. UCP2-dependent redox sensing in POMC neurons regulates feeding.
    Title: UCP2-dependent redox sensing in POMC neurons regulates feeding.
  7. UCP2 KO mice exhibit ameliorated obesity and inflammation induced by high-fat diet feeding.
    Title: UCP2 KO mice exhibit ameliorated obesity and inflammation induced by high-fat diet feeding.
  8. Activating PPARbeta/delta Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
    Title: Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
  9. Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis.
    Title: Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis.
  10. UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia.
    Title: UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia.
Submit: New GeneRIF Correction See all GeneRIFs (189)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-aspartate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chloride transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables malate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables malate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxaloacetate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables oxaloacetate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate ion uniporter activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphate ion uniporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proton transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables secondary active sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables secondary active sulfate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in C4-dicarboxylate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in C4-dicarboxylate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lead ion IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in malate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcium import into the mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxaloacetate(2-) transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to dexamethasone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to fatty acid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to superoxide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to superoxide ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dicarboxylate carrier UCP2
Names
dicarboxylate carrier SLC25A8
mitochondrial uncoupling protein 2
solute carrier family 25 member 8
uncoupling protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417452.1 → NP_001404381.1  dicarboxylate carrier UCP2

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5

  2. NM_001417453.1 → NP_001404382.1  dicarboxylate carrier UCP2

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5
    Related
    ENSMUSP00000146337.2, ENSMUST00000207748.2

  3. NM_001417454.1 → NP_001404383.1  dicarboxylate carrier UCP2

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5

  4. NM_001417455.1 → NP_001404384.1  dicarboxylate carrier UCP2

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5

  5. NM_011671.6 → NP_035801.3  dicarboxylate carrier UCP2

    See identical proteins and their annotated locations for NP_035801.3

    Status: VALIDATED

    Source sequence(s)
    AC117215
    Consensus CDS
    CCDS21498.1
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5, Q8CBU0, Q9R246
    Related
    ENSMUSP00000120967.2, ENSMUST00000126534.8
    Conserved Domains (1) summary
    pfam00153
    Location:115 → 206
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_184451.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215

  2. NR_184452.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100142565..100148832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70406.1 GenPept UniProtKB/Swiss-Prot:P70406

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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