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FCGR1A Fc gamma receptor Ia [ Homo sapiens (human) ]

Gene ID: 2209, updated on 2-Nov-2024

Summary

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Official Symbol
FCGR1Aprovided by HGNC
Official Full Name
Fc gamma receptor Iaprovided by HGNC
Primary source
HGNC:HGNC:3613
See related
Ensembl:ENSG00000150337 MIM:146760; AllianceGenome:HGNC:3613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD64; FCG1; FCRI; CD64A; FCGR1; IGFR1; FcgammaRI
Summary
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 19.0), placenta (RPKM 13.4) and 10 other tissues See more
Orthologs
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Genomic context

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See FCGR1A in Genome Data Viewer
Location:
1q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149782694..149800609)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148906840..148924747)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149754250..149772165)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371406 Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 8-1 Neighboring gene MPRA-validated peak406 silencer Neighboring gene uncharacterized LOC124904411 Neighboring gene H2B clustered histone 18 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149764669-149765433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1654 Neighboring gene H3 clustered histone 13 Neighboring gene H4 clustered histone 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy. Valerius T, et al. Blood, 1993 Aug 1. PMID 7687898
  2. Engineering of recombinant human Fcγ receptor I by directed evolution. Asaoka Y, et al. Protein Eng Des Sel, 2012 Dec. PMID 22967788
  3. Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization. Takai S, et al. Hum Genet, 1994 Jan. PMID 8270248
  4. The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy. Mancardi DA, et al. Blood, 2013 Feb 28. PMID 23293080
  5. Neutrophil CD64 for daily surveillance of systemic infection and necrotizing enterocolitis in preterm infants. Lam HS, et al. Clin Chem, 2013 Dec. PMID 24046202

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
    Title: Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
  2. A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.
    Title: A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.
  3. Prognostic performance of neutrophil CD64 expression in patients with complicated intra-abdominal infections - a prospective study.
    Title: Prognostic performance of neutrophil CD64 expression in patients with complicated intra-abdominal infections - a prospective study.
  4. CD64 expression on neutrophils as a potential biomarker for bacterial infection in ascitic fluid of cirrhotic patients.
    Title: CD64 expression on neutrophils as a potential biomarker for bacterial infection in ascitic fluid of cirrhotic patients.
  5. Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
    Title: Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
  6. Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
    Title: Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
  7. Soluble FcgammaRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.
    Title: Soluble FcγRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.
  8. Fcgamma receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.
    Title: Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.
  9. Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.
    Title: Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.
  10. CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.
    Title: CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.
Submit: New GeneRIF Correction See all GeneRIFs (133)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
  
enables IgG receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables high-affinity IgG receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antibody-dependent cellular cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antibody-dependent cellular cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis, recognition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type III hypersensitivity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type IIa hypersensitivity IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
high affinity immunoglobulin gamma Fc receptor I
Names
Fc fragment of IgG receptor Ia
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ia, receptor for (CD64)
Fc-gamma RI
Fc-gamma receptor I A1
IgG Fc receptor I
fc-gamma RIA
fcgammaRIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007578.1 RefSeqGene

    Range
    4963..14787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_59

mRNA and Protein(s)

  1. NM_000566.4 → NP_000557.1  high affinity immunoglobulin gamma Fc receptor I isoform 2 precursor

    See identical proteins and their annotated locations for NP_000557.1

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Consensus CDS
    CCDS933.1
    UniProtKB/Swiss-Prot
    P12314, P12315, Q5QNW7, Q92495, Q92663
    Related
    ENSP00000358165.4, ENST00000369168.5
    Conserved Domains (3) summary
    cd05752
    Location:22 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104 → 185
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    pfam00047
    Location:196 → 274
    ig; Immunoglobulin domain

  2. NM_001378804.1 → NP_001365733.1  high affinity immunoglobulin gamma Fc receptor I isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:197 → 275
    ig; Immunoglobulin domain
    cd05752
    Location:23 → 101
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:105 → 186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  3. NM_001378805.1 → NP_001365734.1  high affinity immunoglobulin gamma Fc receptor I isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:189 → 267
    ig; Immunoglobulin domain
    cd05752
    Location:15 → 93
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:97 → 178
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  4. NM_001378806.1 → NP_001365735.1  high affinity immunoglobulin gamma Fc receptor I isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:196 → 274
    ig; Immunoglobulin domain
    cd05752
    Location:22 → 100
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:104 → 185
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  5. NM_001378807.1 → NP_001365736.1  high affinity immunoglobulin gamma Fc receptor I isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:173 → 251
    ig; Immunoglobulin domain
    cd05752
    Location:5 → 77
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:81 → 162
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  6. NM_001378808.1 → NP_001365737.1  high affinity immunoglobulin gamma Fc receptor I isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (2) summary
    pfam00047
    Location:112 → 190
    ig; Immunoglobulin domain
    cd05752
    Location:22 → 100
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  7. NM_001378809.1 → NP_001365738.1  high affinity immunoglobulin gamma Fc receptor I isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    UniProtKB/TrEMBL
    C9JSN8
    Conserved Domains (3) summary
    pfam00047
    Location:111 → 189
    ig; Immunoglobulin domain
    cd00096
    Location:122 → 128
    Ig; Ig strand B [structural motif]
    cd05753
    Location:19 → 100
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  8. NM_001378810.1 → NP_001365739.1  high affinity immunoglobulin gamma Fc receptor I isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    UniProtKB/TrEMBL
    C9JSN8
    Related
    ENSP00000394279.1, ENST00000444948.5
    Conserved Domains (3) summary
    pfam00047
    Location:104 → 182
    ig; Immunoglobulin domain
    cd00096
    Location:115 → 121
    Ig; Ig strand B [structural motif]
    cd05753
    Location:16 → 93
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  9. NM_001378811.1 → NP_001365740.1  high affinity immunoglobulin gamma Fc receptor I isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    UniProtKB/TrEMBL
    C9JSN8
    Conserved Domains (3) summary
    pfam00047
    Location:104 → 182
    ig; Immunoglobulin domain
    cd00096
    Location:115 → 121
    Ig; Ig strand B [structural motif]
    cd05753
    Location:16 → 93
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

RNA

  1. NR_166121.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC243772

  2. NR_166122.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC243772

  3. NR_166123.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC243772

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149782694..149800609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    148906840..148924747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12314.2 GenPept UniProtKB/Swiss-Prot:P12314

Gene LinkOut

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Chemical Information
Molecular Biology Databases
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