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Ube2e2 ubiquitin-conjugating enzyme E2E 2 [ Mus musculus (house mouse) ]

Gene ID: 218793, updated on 2-Nov-2024

Summary

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Official Symbol
Ube2e2provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2E 2provided by MGI
Primary source
MGI:MGI:2384997
See related
Ensembl:ENSMUSG00000058317 AllianceGenome:MGI:2384997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in protein modification by small protein conjugation. Predicted to act upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including eye; genitourinary system; gut; integumental system; and nervous system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human UBE2E2 (ubiquitin conjugating enzyme E2 E2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.9), cortex adult (RPKM 15.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2e2 in Genome Data Viewer
Location:
14 A1; 14 7.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (3575429..3896133)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18573563..18894284, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene clusterin like 1, pseudogene 2 Neighboring gene kinesin family member 2C pseudogene Neighboring gene STARR-seq mESC enhancer starr_36061 Neighboring gene STARR-seq mESC enhancer starr_36060 Neighboring gene aurora kinase A pseudogene Neighboring gene predicted gene, 22499 Neighboring gene STARR-seq mESC enhancer starr_36059 Neighboring gene STARR-seq mESC enhancer starr_36058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:19498168-19498444 Neighboring gene STARR-seq mESC enhancer starr_36056 Neighboring gene STARR-seq mESC enhancer starr_36055 Neighboring gene STARR-seq mESC enhancer starr_36054 Neighboring gene predicted gene, 32587 Neighboring gene vacuolar protein sorting 4b pseudogene Neighboring gene farnesyl diphosphate farnesyl transferase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass. Sakurai Y, et al. Diabetes, 2024 Mar 1. PMID 38064504
  2. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of UBE2E2 in Mouse Pancreatic beta-Cells Leads to Glucose Intolerance via Reduction of beta-Cell Mass.
    Title: Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28917

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ISG15 transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ISG15 transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ISG15-protein conjugation IEA
Inferred from Electronic Annotation
more info
  
involved_in ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 E2
Names
E2 ubiquitin-conjugating enzyme E2
TBC1 domain family, member 12
ubiquitin carrier protein E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
ubiquitin-protein ligase E2
NP_001347256.1
NP_001347257.1
NP_659088.1
XP_006518075.1
XP_017171445.1
XP_017171446.1
XP_017171447.1
XP_017171448.1
XP_017171449.1
XP_036014440.1
XP_036014441.1
XP_036014442.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360327.1 → NP_001347256.1  ubiquitin-conjugating enzyme E2 E2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118006, AW495303, BY290283, CF732742, DN172861
    Consensus CDS
    CCDS26838.1
    UniProtKB/Swiss-Prot
    Q91W82
    Related
    ENSMUSP00000075495.4, ENSMUST00000076133.10
    Conserved Domains (1) summary
    pfam00179
    Location:59 → 196
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001360328.1 → NP_001347257.1  ubiquitin-conjugating enzyme E2 E2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AW495303, BY250357, CF732742, CX208846
    UniProtKB/TrEMBL
    D3YXD1
    Related
    ENSMUSP00000118321.2, ENSMUST00000151926.8
    Conserved Domains (1) summary
    pfam00179
    Location:83 → 220
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_144839.2 → NP_659088.1  ubiquitin-conjugating enzyme E2 E2 isoform 1

    See identical proteins and their annotated locations for NP_659088.1

    Status: VALIDATED

    Source sequence(s)
    AC118006, AW495303, BY752670, CF732742, DN172861
    Consensus CDS
    CCDS26838.1
    UniProtKB/Swiss-Prot
    Q91W82
    Related
    ENSMUSP00000115738.2, ENSMUST00000150727.8
    Conserved Domains (1) summary
    pfam00179
    Location:59 → 196
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    3575429..3896133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158547.1 → XP_036014440.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

    Conserved Domains (1) summary
    pfam00179
    Location:59 → 202
    UQ_con; Ubiquitin-conjugating enzyme

  2. XM_017315958.3 → XP_017171447.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

    Conserved Domains (1) summary
    pfam00179
    Location:59 → 210
    UQ_con; Ubiquitin-conjugating enzyme

  3. XM_036158549.1 → XP_036014442.1  ubiquitin-conjugating enzyme E2 E2 isoform X6

    Conserved Domains (1) summary
    pfam00179
    Location:48 → 179
    UQ_con; Ubiquitin-conjugating enzyme

  4. XM_006518012.4 → XP_006518075.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

    Conserved Domains (1) summary
    pfam00179
    Location:59 → 202
    UQ_con; Ubiquitin-conjugating enzyme

  5. XM_017315960.3 → XP_017171449.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

    Conserved Domains (1) summary
    pfam00179
    Location:59 → 210
    UQ_con; Ubiquitin-conjugating enzyme

  6. XM_036158548.1 → XP_036014441.1  ubiquitin-conjugating enzyme E2 E2 isoform X6

    Conserved Domains (1) summary
    pfam00179
    Location:48 → 179
    UQ_con; Ubiquitin-conjugating enzyme

  7. XM_017315957.3 → XP_017171446.1  ubiquitin-conjugating enzyme E2 E2 isoform X2

    Conserved Domains (1) summary
    pfam00179
    Location:83 → 226
    UQ_con; Ubiquitin-conjugating enzyme

  8. XM_017315956.3 → XP_017171445.1  ubiquitin-conjugating enzyme E2 E2 isoform X1

    Conserved Domains (1) summary
    pfam00179
    Location:83 → 234
    UQ_con; Ubiquitin-conjugating enzyme

  9. XM_017315959.3 → XP_017171448.1  ubiquitin-conjugating enzyme E2 E2 isoform X4

    Conserved Domains (1) summary
    pfam00179
    Location:72 → 203
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. XR_004938379.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W82.1 GenPept UniProtKB/Swiss-Prot:Q91W82

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