Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf7l2provided by MGI
Official Full Name: transcription factor 7 like 2, T cell specific, HMG boxprovided by MGI
Primary source: MGI:MGI:1202879
See related: Ensembl:ENSMUSG00000024985 AllianceGenome:MGI:1202879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcf4; TCF4B; TCF4E; Tcf-4
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; and response to glucose. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of cellular response to growth factor stimulus; and nervous system development. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
Expression: Broad expression in whole brain E14.5 (RPKM 35.3), CNS E14 (RPKM 21.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.59 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (55730227..55922091)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (55741797..55933659)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocytic beta-catenin signaling via TCF7L2 regulates synapse development and social behavior.
Title: Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.
The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade.
Title: The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade.
TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain.
Title: TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain.
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice.
Title: Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice.
TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression.
Title: TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression.
TCF7L2 promotes ER stress signaling in diabetic retinopathy.
Title: TCF7L2 promotes ER stress signaling in diabetic retinopathy.
T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling.
Title: T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling.
TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk.
Title: TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk.
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
Title: TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
A beta-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Title: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (9) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

24.MMHAP64FRH9.seq (e-PCR)
- UniSTS:123653

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:239190

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:239191

NoName (e-PCR)
- UniSTS:237978

RH142640 (e-PCR)
- UniSTS:231887

Tcf7l2 (e-PCR), detects polymorphism
- UniSTS:507888

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic hindgut morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of DNA repeat elements	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pituitary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretory granule localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
part_of catenin-TCF7L2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin-TCF7L2 complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor 7-like 2

Names: HMG box transcription factor 4; HMG box transcription factor TCF7L2; T-cell-specific transcription factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142918.2 → NP_001136390.1 transcription factor 7-like 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916, AI451561, AJ223070

Consensus CDS

CCDS50471.1

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

UniProtKB/TrEMBL

E9QQ91

Related

ENSMUSP00000107283.2, ENSMUST00000111656.8

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142919.2 → NP_001136391.1 transcription factor 7-like 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC118695, AC157916, AI451561, AK038720

Consensus CDS

CCDS89418.1

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

UniProtKB/TrEMBL

F6WPX2

Related

ENSMUSP00000123428.3, ENSMUST00000127233.9

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142920.2 → NP_001136392.1 transcription factor 7-like 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916, AI451561, AK035059

Consensus CDS

CCDS50469.1

UniProtKB/TrEMBL

E9Q990, Q8BS68

Related

ENSMUSP00000107286.4, ENSMUST00000111658.10

Conserved Domains (2) summary

cd01388
Location:354 → 421

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142921.2 → NP_001136393.1 transcription factor 7-like 2 isoform 5

See identical proteins and their annotated locations for NP_001136393.1

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Consensus CDS

CCDS50470.1

UniProtKB/TrEMBL

A0A0R4J1G0, Q8BS68

Related

ENSMUSP00000107287.3, ENSMUST00000111659.9

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142922.2 → NP_001136394.1 transcription factor 7-like 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Consensus CDS

CCDS50472.1

UniProtKB/TrEMBL

E9QQ90

Related

ENSMUSP00000107284.4, ENSMUST00000111657.11

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142923.2 → NP_001136395.1 transcription factor 7-like 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Consensus CDS

CCDS50473.1

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

UniProtKB/TrEMBL

D3YWT3

Related

ENSMUSP00000042950.8, ENSMUST00000041717.14

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001142924.2 → NP_001136396.1 transcription factor 7-like 2 isoform 8

See identical proteins and their annotated locations for NP_001136396.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) uses an alternate 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (8) has a substantially shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC118695, AI451561, AK048536, CA750374

Consensus CDS

CCDS50474.1

UniProtKB/TrEMBL

Q8CAI6

Related

ENSMUSP00000107273.2, ENSMUST00000111646.8

Conserved Domains (2) summary

cd01388
Location:170 → 237

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331135.1 → NP_001318064.1 transcription factor 7-like 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/TrEMBL

Q8BS68

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331136.1 → NP_001318065.1 transcription factor 7-like 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331137.1 → NP_001318066.1 transcription factor 7-like 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4
NM_001331138.1 → NP_001318067.1 transcription factor 7-like 2 isoform 12

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331139.1 → NP_001318068.1 transcription factor 7-like 2 isoform 13

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331140.1 → NP_001318069.1 transcription factor 7-like 2 isoform 14

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331141.1 → NP_001318070.1 transcription factor 7-like 2 isoform 15

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331142.1 → NP_001318071.1 transcription factor 7-like 2 isoform 16

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331143.1 → NP_001318072.1 transcription factor 7-like 2 isoform 17

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331144.1 → NP_001318073.1 transcription factor 7-like 2 isoform 18

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/TrEMBL

F6XQR1
NM_001331145.1 → NP_001318074.1 transcription factor 7-like 2 isoform 19

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331146.1 → NP_001318075.1 transcription factor 7-like 2 isoform 20

Status: VALIDATED

Description

Transcript Variant: This variant (21) encodes the longest protein (isoform 20).

Source sequence(s)

AC118695, AC137148, AC157916

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331147.1 → NP_001318076.1 transcription factor 7-like 2 isoform 21

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331148.1 → NP_001318077.1 transcription factor 7-like 2 isoform 22

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331149.1 → NP_001318078.1 transcription factor 7-like 2 isoform 23

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/TrEMBL

F6XQR1

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001331150.1 → NP_001318079.1 transcription factor 7-like 2 isoform 24

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

UniProtKB/TrEMBL

F6XQR1

Conserved Domains (2) summary

cd01388
Location:353 → 420

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001412695.1 → NP_001399624.1 transcription factor 7-like 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916
NM_001412705.1 → NP_001399634.1 transcription factor 7-like 2 isoform 25

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916
NM_001412706.1 → NP_001399635.1 transcription factor 7-like 2 isoform 26

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Related

ENSMUSP00000118661.3, ENSMUST00000153888.9
NM_001412707.1 → NP_001399636.1 transcription factor 7-like 2 isoform 27

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916
NM_001412708.1 → NP_001399637.1 transcription factor 7-like 2 isoform 28

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916
NM_001412710.1 → NP_001399639.1 transcription factor 7-like 2 isoform 29

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916
NM_001412711.1 → NP_001399640.1 transcription factor 7-like 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916
NM_009333.4 → NP_033359.2 transcription factor 7-like 2 isoform 3

See identical proteins and their annotated locations for NP_033359.2

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

Consensus CDS

CCDS29911.1

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

UniProtKB/TrEMBL

F6WBK9

Related

ENSMUSP00000050081.10, ENSMUST00000061496.17

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding

RNA

NR_138565.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC118695, AC137148, AC157916

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

55730227..55922091

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318116.3 → XP_017173605.1 transcription factor 7-like 2 isoform X9

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:358 → 425

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006526860.5 → XP_006526923.1 transcription factor 7-like 2 isoform X1

Conserved Domains (2) summary

cd01388
Location:358 → 425

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006526861.5 → XP_006526924.1 transcription factor 7-like 2 isoform X2

Conserved Domains (2) summary

cd01388
Location:354 → 421

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_017318115.3 → XP_017173604.1 transcription factor 7-like 2 isoform X8

UniProtKB/TrEMBL

F6XQR1

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_017318119.3 → XP_017173608.1 transcription factor 7-like 2 isoform X11

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:349 → 416

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 259

CTNNB1_binding; N-terminal CTNNB1 binding
XM_036161506.1 → XP_036017399.1 transcription factor 7-like 2 isoform X12

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006526866.5 → XP_006526929.1 transcription factor 7-like 2 isoform X4

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250847.2 → XP_030106707.1 transcription factor 7-like 2 isoform X6

Conserved Domains (2) summary

cd01388
Location:335 → 402

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_036161508.1 → XP_036017401.1 transcription factor 7-like 2 isoform X17

UniProtKB/TrEMBL

F6XQR1

Conserved Domains (2) summary

cd01388
Location:330 → 397

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_017318112.3 → XP_017173601.1 transcription factor 7-like 2 isoform X5

Conserved Domains (2) summary

cd01388
Location:331 → 398

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_036161507.1 → XP_036017400.1 transcription factor 7-like 2 isoform X13

UniProtKB/Swiss-Prot

O70574, Q8C834, Q91XP2, Q91XP3, Q91XP4, Q924A0, Q924A1, Q9Z0V3, Q9Z0V4

Conserved Domains (2) summary

cd01388
Location:326 → 393

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:17 → 236

CTNNB1_binding; N-terminal CTNNB1 binding
XM_017318132.2 → XP_017173621.1 transcription factor 7-like 2 isoform X22

Conserved Domains (2) summary

cd01388
Location:170 → 237

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250860.1 → XP_030106720.1 transcription factor 7-like 2 isoform X28

Conserved Domains (2) summary

cd01388
Location:170 → 237

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006526895.4 → XP_006526958.1 transcription factor 7-like 2 isoform X20

See identical proteins and their annotated locations for XP_006526958.1

Conserved Domains (2) summary

cd01388
Location:175 → 242

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250859.1 → XP_030106719.1 transcription factor 7-like 2 isoform X27

UniProtKB/TrEMBL

Q8CAI6

Conserved Domains (2) summary

cd01388
Location:170 → 237

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006526897.4 → XP_006526960.1 transcription factor 7-like 2 isoform X23

Conserved Domains (2) summary

cd01388
Location:170 → 237

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250854.1 → XP_030106714.1 transcription factor 7-like 2 isoform X25

Conserved Domains (2) summary

cd01388
Location:166 → 233

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_017318135.3 → XP_017173624.1 transcription factor 7-like 2 isoform X29

UniProtKB/TrEMBL

Q8CAI6

Conserved Domains (2) summary

cd01388
Location:166 → 233

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_006526894.5 → XP_006526957.1 transcription factor 7-like 2 isoform X19

See identical proteins and their annotated locations for XP_006526957.1

Conserved Domains (2) summary

cd01388
Location:175 → 242

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250855.2 → XP_030106715.1 transcription factor 7-like 2 isoform X26

Conserved Domains (2) summary

cd01388
Location:175 → 242

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250851.2 → XP_030106711.1 transcription factor 7-like 2 isoform X21

Conserved Domains (2) summary

cd01388
Location:171 → 238

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding
XM_030250853.2 → XP_030106713.1 transcription factor 7-like 2 isoform X24

Conserved Domains (2) summary

cd01388
Location:166 → 233

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:2 → 76

CTNNB1_binding; N-terminal CTNNB1 binding