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Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 20527, updated on 14-Nov-2024

Summary

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Official Symbol
Slc2a3provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 3provided by MGI
Primary source
MGI:MGI:95757
See related
Ensembl:ENSMUSG00000003153 AllianceGenome:MGI:95757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut3; Glut-3
Summary
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in D-glucose transmembrane transport and dehydroascorbic acid transport. Located in acrosomal membrane and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; early conceptus; and genitourinary system. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 213.3), placenta adult (RPKM 31.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Slc2a3 in Genome Data Viewer
Location:
6 F2; 6 57.82 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122704783..122779149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122727809..122802363, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Nanog 5' regulatory region Neighboring gene predicted pseudogene 10224 Neighboring gene Nanog homeobox Neighboring gene Nanog +60 enhancer Neighboring gene uridine-cytidine kinase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3679 Neighboring gene STARR-positive B cell enhancer ABC_E283 Neighboring gene predicted gene 5112 Neighboring gene forkhead box J2 Neighboring gene microRNA 7231

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos. Nagamatsu S, et al. Biochem J, 1994 May 15. PMID 8198523, Free PMC Article
  2. Glucose Transporter 3 is Essential for the Survival of Breast Cancer Cells in the Brain. Kuo MH, et al. Cells, 2019 Dec 4. PMID 31817208, Free PMC Article
  3. Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3. Zhu J, et al. Cell Mol Neurobiol, 2020 Aug. PMID 31884568, Free PMC Article
  4. CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3. Fu C, et al. Cancer Sci, 2021 Mar. PMID 33368883, Free PMC Article
  5. Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders. Shin BC, et al. Exp Neurol, 2021 Apr. PMID 33482226, Free PMC Article

See all (158) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
    Title: LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
  2. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
    Title: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
  3. Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
    Title: Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.
  4. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
    Title: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
  5. Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
    Title: Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
  6. Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
    Title: Analysis of glucose metabolism by (18)F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.
  7. Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
    Title: Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
  8. High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
    Title: High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.
  9. CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
    Title: CD205(+) polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.
  10. Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
    Title: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose binding ISO
Inferred from Sequence Orthology
more info
  
enables D-glucose binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables dehydroascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dehydroascorbic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables fructose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables galactose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables galactose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables galactoside binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables monosaccharide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables xylose binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in D-glucose import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within D-glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dehydroascorbic acid transport ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in fructose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in galactose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monosaccharide transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 3
Names
glucose transporter type 3, brain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410371.1 → NP_001397300.1  solute carrier family 2, facilitated glucose transporter member 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC131715

  2. NM_001410372.1 → NP_001397301.1  solute carrier family 2, facilitated glucose transporter member 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC131715, AC163108

  3. NM_001410374.1 → NP_001397303.1  solute carrier family 2, facilitated glucose transporter member 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC131715, AC163108

  4. NM_001410375.1 → NP_001397304.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC131715, AC163108

  5. NM_001410376.1 → NP_001397305.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC131715, AC163108

  6. NM_001410377.1 → NP_001397306.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC131715, AC163108

  7. NM_001410378.1 → NP_001397307.1  solute carrier family 2, facilitated glucose transporter member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC131715, AC163108

  8. NM_011401.5 → NP_035531.3  solute carrier family 2, facilitated glucose transporter member 3 isoform b

    See identical proteins and their annotated locations for NP_035531.3

    Status: VALIDATED

    Source sequence(s)
    AC131715
    Consensus CDS
    CCDS20502.1
    UniProtKB/Swiss-Prot
    P32037
    UniProtKB/TrEMBL
    Q3TPL8, Q4FJP8, Q8BLF7
    Related
    ENSMUSP00000032476.5, ENSMUST00000032476.11
    Conserved Domains (2) summary
    cd06174
    Location:14 → 437
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:13 → 465
    Sugar_tr; Sugar (and other) transporter

RNA

  1. NR_177063.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131715

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122704783..122779149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165983.1 → XP_036021876.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

    UniProtKB/TrEMBL
    Q4FJP8, Q8BLF7
    Conserved Domains (1) summary
    cd17431
    Location:14 → 458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32037.1 GenPept UniProtKB/Swiss-Prot:P32037

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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