Foxp3 forkhead box P3 [ Mus musculus (house mouse) ]

Gene ID: 20371, updated on 10-Oct-2024

Summary

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Official Symbol: Foxp3provided by MGI
Official Full Name: forkhead box P3provided by MGI
Primary source: MGI:MGI:1891436
See related: Ensembl:ENSMUSG00000039521 AllianceGenome:MGI:1891436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sf; JM2; scurfin
Summary: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in spleen adult (RPKM 3.0), thymus adult (RPKM 2.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See Foxp3 in Genome Data Viewer

Location:: X A1.1; X 3.41 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7445915..7461482)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7579676..7595243)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Forkhead Box P3 in IFNgamma-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition.
Title: Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition.
The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes.
Title: The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes.
miR-155 promotes Th17 differentiation by targeting FOXP3 to aggravate inflammation in MRSA pneumonia.
Title: miR-155 promotes Th17 differentiation by targeting FOXP3 to aggravate inflammation in MRSA pneumonia.
ADENOSINE INFLUENCES FOXP3 EXPRESSION OF T REGS VIA THE A2AR/CREB PATHWAY IN A MOUSE MODEL OF SEPSIS.
Title: ADENOSINE INFLUENCES FOXP3 EXPRESSION OF T REGS VIA THE A2AR/CREB PATHWAY IN A MOUSE MODEL OF SEPSIS.
Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
Title: Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARgamma/miR-7b-5p/Sp1 signaling pathway.
Title: Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway.
Characterizing Foxp3[+] and Foxp3[-] T cells in the homeostatic state and after allo-activation: resting CD4[+]Foxp3[+] Tregs have molecular characteristics of activated T cells.
Title: Characterizing Foxp3(+) and Foxp3(-) T cells in the homeostatic state and after allo-activation: resting CD4(+)Foxp3(+) Tregs have molecular characteristics of activated T cells.
Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
Title: Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3.
Title: IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3.
Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells.
Title: Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells.

Submit: New GeneRIF Correction See all GeneRIFs (480)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (12) 1 citation
Spontaneous (1) 1 citation
Targeted (31) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136802 (e-PCR)
- UniSTS:218891

AI481216 (e-PCR)
- UniSTS:164663

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables NFAT protein binding	ISO Inferred from Sequence Orthology more info
enables NFAT protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment	TAS Traceable Author Statement more info	PubMed
acts_upstream_of CD4-positive, alpha-beta T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of T cell anergy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of endothelial blood-brain barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of isotype switching to IgE isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of chronic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of chronic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of T cell anergy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peripheral T cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta1 production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell anergy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of regulatory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to rapamycin	IEA Inferred from Electronic Annotation more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tolerance induction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tolerance induction to self antigen	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transforming growth factor beta1 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: forkhead box protein P3

Names: scurfy

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.