ZNF449 zinc finger protein 449 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF449provided by HGNC
Official Full Name: zinc finger protein 449provided by HGNC
Primary source: HGNC:HGNC:21039
See related: Ensembl:ENSG00000173275 MIM:300627; AllianceGenome:HGNC:21039
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZSCAN19
Summary: This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]
Expression: Ubiquitous expression in adrenal (RPKM 2.8), thyroid (RPKM 2.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq26.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (135344796..135363413)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (133670603..133689215)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (134478721..134497338)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

During chondrogenic differentiation of human mesenchymal stem cells, ZNF449 was increased at an early stage, and its overexpression enhanced SOX9 and SOX6 only at the initial stage of the differentiation.
Title: Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis.
ZNF449 is a member of the zinc-finger family and it may function as a transcription factor
Title: Identification and characterization of the human SCAN domain zinc-finger gene ZNF449.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogonial cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 449

Names: zinc finger and SCAN domain-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021220.1 RefSeqGene

Range

5026..23643

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_152695.6 → NP_689908.3 zinc finger protein 449

See identical proteins and their annotated locations for NP_689908.3

Status: REVIEWED

Source sequence(s)

AY280801, BC060768, BX537604, DA319333

Consensus CDS

CCDS14649.1

UniProtKB/Swiss-Prot

Q5JRZ7, Q5JRZ8, Q6NZX2, Q6P9G9, Q8N3Q1, Q8TED7

Related

ENSP00000339585.4, ENST00000339249.5

Conserved Domains (5) summary

COG5048
Location:321 → 483

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:235 → 402

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:477 → 502

zf-H2C2_2; Zinc-finger double domain

cl02605
Location:27 → 134

SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

135344796..135363413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441915.1 → XP_047297871.1 zinc finger protein 449 isoform X2
XM_047441914.1 → XP_047297870.1 zinc finger protein 449 isoform X1

UniProtKB/Swiss-Prot

Q5JRZ7, Q5JRZ8, Q6NZX2, Q6P9G9, Q8N3Q1, Q8TED7
XM_017029351.2 → XP_016884840.1 zinc finger protein 449 isoform X2

Conserved Domains (5) summary

cd11674
Location:178 → 231

lambda-1; inner capsid protein lambda-1 or VP3

COG5048
Location:206 → 359

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:210 → 230

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:208 → 230

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:306 → 331

zf-H2C2_2; Zinc-finger double domain