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Lamc2 laminin subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192362, updated on 2-Nov-2024

Summary

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Official Symbol
Lamc2provided by RGD
Official Full Name
laminin subunit gamma 2provided by RGD
Primary source
RGD:621053
See related
EnsemblRapid:ENSRNOG00000002667 AllianceGenome:RGD:621053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heparin binding activity. Predicted to be involved in several processes, including axon guidance; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in cell cortex; extracellular space; and perinuclear region of cytoplasm. Part of laminin-2 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 136.0), Heart (RPKM 95.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lamc2 in Genome Data Viewer
Location:
13q21
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67835199..67894694, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65284664..65344164, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70566643..70632126, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481571 Neighboring gene ribosomal protein S2, pseudogene 37 Neighboring gene uncharacterized LOC120096279 Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene laminin subunit gamma 1 Neighboring gene ornithine decarboxylase-like Neighboring gene SHC binding and spindle associated 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer. Korbakis D, et al. Br J Cancer, 2015 Jul 28. PMID 26180921, Free PMC Article
  2. Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa. Pulkkinen L, et al. Nat Genet, 1994 Mar. PMID 8012393
  3. Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium. Tanno M, et al. J Periodontal Res, 2006 Feb. PMID 16409251
  4. Laminin-5γ2 chain expression is associated with tumor cell invasiveness and prognosis of lung squamous cell carcinoma. Masuda R, et al. Biomed Res, 2012. PMID 23124251
  5. Toxicogenomic biomarkers for renal papillary injury in rats. Uehara T, et al. Toxicology, 2013 Jan 7. PMID 23142791

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study aimed to identify genomic biomarkers for early and sensitive detection of renal papillary injury in rats; Timp1, Igf1, and Lamc2 exhibited the best prediction performance
    Title: Toxicogenomic biomarkers for renal papillary injury in rats.
  2. Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
    Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
  3. In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
    Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of laminin-2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of laminin-5 complex ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
laminin subunit gamma-2
Names
lamimin, gamma 2
laminin, gamma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100640.3 → NP_001094110.1  laminin subunit gamma-2 precursor

    See identical proteins and their annotated locations for NP_001094110.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    F1LRH4
    Related
    ENSRNOP00000037099.5, ENSRNOT00000036947.7
    Conserved Domains (7) summary
    cl14654
    Location:1039 → 1159
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00281
    Location:245 → 370
    LamB; Laminin B domain
    COG0840
    Location:769 → 1165
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd00055
    Location:83 → 127
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00185
    Location:445 → 481
    TNFRSF; CRD2 [structural motif]
    pfam00053
    Location:139 → 184
    Laminin_EGF; Laminin EGF domain
    cl22855
    Location:437 → 501
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    67835199..67894694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769603.4 → XP_008767825.1  laminin subunit gamma-2 isoform X1

    See identical proteins and their annotated locations for XP_008767825.1

    UniProtKB/TrEMBL
    F1LRH4
    Related
    ENSRNOP00000099868.1, ENSRNOT00000131794.1
    Conserved Domains (7) summary
    cl14654
    Location:1039 → 1159
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00281
    Location:245 → 370
    LamB; Laminin B domain
    COG0840
    Location:769 → 1165
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd00055
    Location:83 → 127
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00185
    Location:445 → 481
    TNFRSF; CRD2 [structural motif]
    pfam00053
    Location:139 → 184
    Laminin_EGF; Laminin EGF domain
    cl22855
    Location:437 → 501
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version

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