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Pja2 praja ring finger ubiquitin ligase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192256, updated on 17-Aug-2024

Summary

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Official Symbol
Pja2provided by RGD
Official Full Name
praja ring finger ubiquitin ligase 2provided by RGD
Primary source
RGD:620273
See related
EnsemblRapid:ENSRNOG00000015528 AllianceGenome:RGD:620273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
praja2; Neurodap1
Summary
Predicted to enable protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Involved in long-term memory and regulation of protein kinase A signaling. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 939.4), Heart (RPKM 310.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pja2 in Genome Data Viewer
Location:
9q37
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (111403624..111453703, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (103956678..104006763, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (111998204..112048847, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480617 Neighboring gene FER tyrosine kinase Neighboring gene uncharacterized LOC108351980 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102552268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse. Nakayama M, et al. J Neurosci, 1995 Jul. PMID 7623148, Free PMC Article
  2. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Zhong J, et al. Cell Death Dis, 2017 May 4. PMID 28471450, Free PMC Article
  3. Control of PKA stability and signalling by the RING ligase praja2. Lignitto L, et al. Nat Cell Biol, 2011 Apr. PMID 21423175
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC91486

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A catalytic subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A regulatory subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Praja-2
Names
RING-type E3 ubiquitin transferase Praja-2
praja 2, RING-H2 motif containing
praja ring finger 2, E3 ubiquitin protein ligase
protein carrying the RING-H2 sequence motif
NP_001264207.1
NP_620251.1
XP_017451755.1
XP_063122694.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277278.1 → NP_001264207.1  E3 ubiquitin-protein ligase Praja-2 isoform 2

    See identical proteins and their annotated locations for NP_001264207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC074015, CB577390, JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0H2UHM9, A6JRB0
    Related
    ENSRNOP00000021258.5, ENSRNOT00000021258.9
    Conserved Domains (1) summary
    pfam13639
    Location:571 → 612
    zf-RING_2; Ring finger domain

  2. NM_138896.2 → NP_620251.1  E3 ubiquitin-protein ligase Praja-2 isoform 1

    See identical proteins and their annotated locations for NP_620251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC074015, CB577390, JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q63364
    UniProtKB/TrEMBL
    A6JRB1
    Related
    ENSRNOP00000072362.1, ENSRNOT00000080962.3
    Conserved Domains (3) summary
    PRK11151
    Location:210 → 241
    PRK11151; DNA-binding transcriptional regulator OxyR; Provisional
    COG5271
    Location:269 → 628
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd16465
    Location:632 → 677
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    111403624..111453703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266624.1 → XP_063122694.1  E3 ubiquitin-protein ligase Praja-2 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHM9, A6JRB0

  2. XM_017596266.2 → XP_017451755.1  E3 ubiquitin-protein ligase Praja-2 isoform X1

    UniProtKB/Swiss-Prot
    Q63364
    UniProtKB/TrEMBL
    A6JRB1
    Conserved Domains (3) summary
    PRK11151
    Location:210 → 241
    PRK11151; DNA-binding transcriptional regulator OxyR; Provisional
    COG5271
    Location:269 → 628
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd16465
    Location:632 → 677
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63364.1 GenPept UniProtKB/Swiss-Prot:Q63364

Gene LinkOut

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