Psmb5 proteasome (prosome, macropain) subunit, beta type 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmb5provided by MGI
Official Full Name: proteasome (prosome, macropain) subunit, beta type 5provided by MGI
Primary source: MGI:MGI:1194513
See related: Ensembl:ENSMUSG00000022193 AllianceGenome:MGI:1194513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables peptidase activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process and response to oxidative stress. Part of proteasome core complex. Is expressed in embryo. Orthologous to human PSMB5 (proteasome 20S subunit beta 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 108.4), ovary adult (RPKM 85.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54851577..54855452, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54614120..54617995, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The P2Y2R enhances Ubiquitin-Proteasome System activity by increasing the subunits expression beta 5 and beta 1.
Title: Regulation of proteasome activity by P2Y(2) receptor underlies the neuroprotective effects of extracellular nucleotides.
The role of the ubiquitin-proteasome system in pressure overloaded hearts andheart failure.
Title: Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload.
Probeta5 predominantly promotes integration into LMP2/MECL-1-containing precursors in IFNgamma-stimulated, LMP7-deficient cells and infected LMP7-deficient mice.
Title: The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes.
Data demonstrate that TNF-alpha expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome.
Title: LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Psmb5 (e-PCR), detects polymorphism
- UniSTS:144274

PMC262680P1 (e-PCR)
- UniSTS:272321

PMC262680P2 (e-PCR)
- UniSTS:272322

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit beta type-5

Names: beta-5; macropain epsilon chain; multicatalytic endopeptidase complex epsilon chain; proteasome beta type subunit 5; proteasome chain 6; proteasome epsilon chain; proteasome subunit X; proteasome subunit beta-5

NP_035316.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011186.1 → NP_035316.1 proteasome subunit beta type-5

See identical proteins and their annotated locations for NP_035316.1

Status: VALIDATED

Source sequence(s)

AF060091

Consensus CDS

CCDS27095.1

UniProtKB/Swiss-Prot

O55234, Q3UZI1, Q91X53, Q9CWR4, Q9R1P2

Related

ENSMUSP00000022803.5, ENSMUST00000022803.6

Conserved Domains (1) summary

cd03761
Location:60 → 247

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...