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Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]

Gene ID: 19108, updated on 2-Nov-2024

Summary

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Official Symbol
Prkxprovided by MGI
Official Full Name
protein kinase, X-linkedprovided by MGI
Primary source
MGI:MGI:1309999
See related
Ensembl:ENSMUSG00000035725 AllianceGenome:MGI:1309999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKX1; Pkare
Summary
Predicted to enable cAMP-dependent protein kinase activity. Involved in angiogenesis; cell adhesion; and endothelial cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; cardiovascular system; central nervous system; gonad; and gut. Orthologous to several human genes including PRKX (protein kinase cAMP-dependent X-linked catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 7.5), CNS E18 (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prkx in Genome Data Viewer
Location:
X B; X 38.32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (76804578..76839545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (77760972..77796235, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 pseudogene Neighboring gene probasin Neighboring gene predicted gene 14744

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Man to mouse--lessons learned from the distal end of the human X chromosome. Blaschke RJ, et al. Genome Res, 1997 Dec. PMID 9414316
  2. A novel murine PKA-related protein kinase involved in neuronal differentiation. Blaschke RJ, et al. Genomics, 2000 Mar 1. PMID 10729225
  3. Profiles of PrKX expression in developmental mouse embryo and human tissues. Li W, et al. J Histochem Cytochem, 2005 Aug. PMID 15879576
  4. PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Li X, et al. Dev Biol, 2011 Aug 15. PMID 21684272
  5. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. Li X, et al. Biochim Biophys Acta, 2008 Jan. PMID 17980165

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis.
    Title: PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial tube morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in kidney morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of epithelial cell differentiation involved in kidney development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase catalytic subunit PRKX
Names
PKA-related protein kinase
putative serine/threonine kinase
serine/threonine-protein kinase PRKX
NP_001398615.1
NP_001398616.1
NP_001398618.1
NP_001398621.1
NP_001398623.1
NP_001398630.1
NP_001398631.1
NP_001398632.1
NP_001398633.1
NP_058675.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411686.1 → NP_001398615.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL714017

  2. NM_001411687.1 → NP_001398616.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL714017

  3. NM_001411689.1 → NP_001398618.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL714017

  4. NM_001411692.1 → NP_001398621.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL714017

  5. NM_001411694.1 → NP_001398623.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL714017

  6. NM_001411701.1 → NP_001398630.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL714017

  7. NM_001411702.1 → NP_001398631.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL714017

  8. NM_001411703.1 → NP_001398632.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL714017

  9. NM_001411704.1 → NP_001398633.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL714017

  10. NM_016979.2 → NP_058675.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 1

    See identical proteins and their annotated locations for NP_058675.1

    Status: VALIDATED

    Source sequence(s)
    AK034681, AK037141, AK143039, BE943829, BG074563, CJ136116
    Consensus CDS
    CCDS30248.1
    UniProtKB/Swiss-Prot
    B1AVU0, Q3UCD1, Q8BHD6, Q922R0, Q9QZ12
    UniProtKB/TrEMBL
    Q3UDT1
    Related
    ENSMUSP00000045304.8, ENSMUST00000036333.14
    Conserved Domains (2) summary
    PTZ00263
    Location:31 → 355
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd05612
    Location:44 → 335
    STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    76804578..76839545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922R0.1 GenPept UniProtKB/Swiss-Prot:Q922R0

Gene LinkOut

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