Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkar1aprovided by MGI
Official Full Name: protein kinase, cAMP dependent regulatory, type I, alphaprovided by MGI
Primary source: MGI:MGI:104878
See related: Ensembl:ENSMUSG00000020612 AllianceGenome:MGI:104878
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tse1; Tse-1; RIalpha; 1300018C22Rik
Summary: The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 81.7), cerebellum adult (RPKM 81.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 72.33 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (109539849..109560489)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (109649023..109669663)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.
Title: Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.
Loss of PKA regulatory subunit 1alpha aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury.
Title: Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury.
Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
Title: Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
Identification of circular RNA-associated competing endogenous RNA network in the development of cleft palate.
Title: Identification of circular RNA-associated competing endogenous RNA network in the development of cleft palate.
Study evaluated the role of PKA signaling alterations in adrenal homeostasis and differentiation by generating mice with targeted Prkar1a genetic ablation specifically in adrenal cortex and proposed that PKA-mediated cortex remodeling not only influences the establishment of adrenarche, but also is part of sexually dimorphic mechanisms that could help to explain the overrepresentation of adrenocortical diseases in women.
Title: PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.
Mice with a genetic background of Tpo-Cre;Prkar1a(flox/flox);Epac1(-/-) are aggressive, and both the thyroid-specific knockout of Prkar1a and global knockout of Epac1 likely contribute to this aggressive behavior. This study supports the hypothesis that altered thyroid signaling and aggressive behavior are linked.
Title: Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion.
This mouse knockout model supports the role of prkar1a as a tumor suppressor gene in the pancreas and points to the PKA pathway as a possible therapeutic target for these lesions.
Title: Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis.
This model, the first describing the germline expression of a PRKAR1A mutation causing dominant repression of cAMP-dependent PKA, reproduced the main features of acrodysostosis 1 in humans.
Title: Knock-In of the Recurrent R368X Mutation of PRKAR1A that Represses cAMP-Dependent Protein Kinase A Activation: A Model of Type 1 Acrodysostosis.
These results therefore provide new information on the complex regulation of cellular death under endoplasmic reticulum stress conditions and bring new insights on the conditions that regulate the pro- versus anti-death functions of PKA.
Title: A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress.
This study demonstrated that loss of one Prkar1a allele was associated with a significant increase in PKA activity in the basolateral (BLA) and central (CeA) amygdala and ventromedial hypothalamus (VMH) in both Prkar1a(+/-) and Prkar1a(+/-)/Prkaca(+/-) mice.
Title: Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA's catalytic subunits in anxiety.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP-dependent protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucagon stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal cell proliferation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP/PKA signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axoneme	IEA Inferred from Electronic Annotation more info
colocalizes_with axoneme	ISO Inferred from Sequence Orthology more info
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
colocalizes_with immunological synapse	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sperm head-tail coupling apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cAMP-dependent protein kinase type I-alpha regulatory subunit

Names: protein kinase, cAMP dependent regulatory, type 1, alpha

NP_001300902.1

EC 2.7.11.1

NP_001300903.1

EC 2.7.11.1

NP_001300904.1

EC 2.7.11.1

NP_001300905.1

EC 2.7.11.1

NP_001349606.1

EC 2.7.11.1

NP_001360841.1

EC 2.7.11.1

NP_001360842.1

EC 2.7.11.1

NP_068680.1

EC 2.7.11.1

XP_036012323.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313973.2 → NP_001300902.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AK051068, AL732387, BB610165, BP754173, BY309580

Consensus CDS

CCDS25583.1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Related

ENSMUSP00000102288.2, ENSMUST00000106677.8

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001313974.2 → NP_001300903.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AK051068, AL732387, BP754173, BY129491

Consensus CDS

CCDS25583.1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001313975.2 → NP_001300904.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AK051068, AL732387, BB850806, BP754173, CX243222

Consensus CDS

CCDS25583.1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001313976.2 → NP_001300905.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AK051068, AL732387, BB850806, BP754173, CF727817

Consensus CDS

CCDS25583.1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001362677.1 → NP_001349606.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AL732387, BP754173

Consensus CDS

CCDS25583.1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001373912.1 → NP_001360841.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AK158562, AL732387

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001373913.1 → NP_001360842.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

Status: REVIEWED

Source sequence(s)

AK005039, AL732387

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Related

ENSMUSP00000056500.7, ENSMUST00000049527.7

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_021880.4 → NP_068680.1 cAMP-dependent protein kinase type I-alpha regulatory subunit

See identical proteins and their annotated locations for NP_068680.1

Status: REVIEWED

Source sequence(s)

AL732387, BP754173

Consensus CDS

CCDS25583.1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

109539849..109560489

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156430.1 → XP_036012323.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/Swiss-Prot

Q3UKU7, Q9DBC7, Q9JHR5, Q9JHR6

UniProtKB/TrEMBL

Q8C3Z4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...