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Pfdn2 prefoldin 2 [ Mus musculus (house mouse) ]

Gene ID: 18637, updated on 2-Nov-2024

Summary

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Official Symbol
Pfdn2provided by MGI
Official Full Name
prefoldin 2provided by MGI
Primary source
MGI:MGI:1276111
See related
Ensembl:ENSMUSG00000006412 AllianceGenome:MGI:1276111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM27
Summary
Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Acts upstream of or within protein folding. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 48.2), CNS E14 (RPKM 27.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pfdn2 in Genome Data Viewer
Location:
1 H3; 1 79.35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171172522..171186822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171344954..171359254)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene death effector domain-containing Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene nitrilase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4 Neighboring gene STARR-positive B cell enhancer ABC_E4388 Neighboring gene Rho GTPase activating protein 30 Neighboring gene STARR-positive B cell enhancer ABC_E4389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multipronged approach to identify and validate a novel upstream regulator of Sncg in mouse retinal ganglion cells. Chintalapudi SR, et al. FEBS J, 2016 Feb. PMID 26663874
  2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Vainberg IE, et al. Cell, 1998 May 29. PMID 9630229
  3. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Transgenic (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
  
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  
part_of prefoldin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prefoldin subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360824.1 → NP_001347753.1  prefoldin subunit 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC087229
    UniProtKB/TrEMBL
    F8WJ30
    Related
    ENSMUSP00000006579.5, ENSMUST00000006579.5
    Conserved Domains (1) summary
    pfam01920
    Location:24 → 96
    Prefoldin_2; Prefoldin subunit

  2. NM_001360825.1 → NP_001347754.1  prefoldin subunit 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC087229
    Conserved Domains (1) summary
    pfam01920
    Location:1 → 79
    Prefoldin_2; Prefoldin subunit

  3. NM_011070.4 → NP_035200.2  prefoldin subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_035200.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15491.1
    UniProtKB/Swiss-Prot
    O70591, Q8R0H2
    Related
    ENSMUSP00000120106.2, ENSMUST00000135941.8
    Conserved Domains (1) summary
    pfam01920
    Location:24 → 127
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171172522..171186822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70591.2 GenPept UniProtKB/Swiss-Prot:O70591

Gene LinkOut

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