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Pecam1 platelet/endothelial cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 18613, updated on 2-Nov-2024

Summary

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Official Symbol
Pecam1provided by MGI
Official Full Name
platelet/endothelial cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:97537
See related
Ensembl:ENSMUSG00000020717 AllianceGenome:MGI:97537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd31; Pecam; PECAM-1
Summary
Predicted to enable protein homodimerization activity; protein phosphatase binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including Rho protein signal transduction; endothelial cell morphogenesis; and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including cell-cell contact zone; external side of plasma membrane; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease; coronary stenosis; myocardial infarction; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 94.3), subcutaneous fat pad adult (RPKM 41.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Pecam1 in Genome Data Viewer
Location:
11 E1; 11 69.92 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106545039..106606107, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106654213..106715281, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22711 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene testis expressed gene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106397706-106397815 Neighboring gene STARR-seq mESC enhancer starr_30931 Neighboring gene STARR-positive B cell enhancer ABC_E5288 Neighboring gene STARR-positive B cell enhancer ABC_E1150 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106535909-106536110 Neighboring gene STARR-seq mESC enhancer starr_30943 Neighboring gene STARR-seq mESC enhancer starr_30946 Neighboring gene predicted gene, 51950 Neighboring gene STARR-positive B cell enhancer ABC_E10724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106611859-106612059 Neighboring gene STARR-positive B cell enhancer ABC_E5289 Neighboring gene STARR-positive B cell enhancer ABC_E4006 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. Schenkel AR, et al. J Immunol, 2004 Nov 15. PMID 15528380
  2. The critical role of uterine CD31 as a post-progesterone signal in early pregnancy. Lee SH, et al. Reproduction, 2017 Nov. PMID 28780571
  3. Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium. Feng D, et al. J Histochem Cytochem, 2004 Jan. PMID 14688220
  4. Haemodynamics Regulate Fibronectin Assembly via PECAM. Chen Z, et al. Sci Rep, 2017 Jan 25. PMID 28120882, Free PMC Article
  5. Role for platelet-endothelial cell adhesion molecule-1 in macrophage Fcgamma receptor function. Albelda SM, et al. Am J Respir Cell Mol Biol, 2004 Aug. PMID 15087304

See all (1000) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy.
    Title: Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy.
  2. Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.
    Title: Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.
  3. Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke.
    Title: Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke.
  4. CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation.
    Title: CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation.
  5. PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
    Title: PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
  6. Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
    Title: Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
  7. Inhibition of PECAM-1 Significantly Delays Leukocyte Extravasation into the Subcortex Post-Stroke.
    Title: Inhibition of PECAM-1 Significantly Delays Leukocyte Extravasation into the Subcortex Post-Stroke.
  8. Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
    Title: Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
  9. PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin.
    Title: PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin.
  10. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke.
    Title: Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke.
Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Polg2

Homology

Clone Names

  • MGC102160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in diapedesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endothelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endothelial cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
platelet endothelial cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032378.2 → NP_001027550.1  platelet endothelial cell adhesion molecule isoform 2 precursor

    See identical proteins and their annotated locations for NP_001027550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 3' coding exon but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK169431, BC085502, BE692027, BY781761
    Consensus CDS
    CCDS25558.1
    UniProtKB/TrEMBL
    B1ARB3
    Related
    ENSMUSP00000099358.4, ENSMUST00000103069.10
    Conserved Domains (3) summary
    smart00410
    Location:33 → 117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317 → 393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33 → 107
    Ig; Immunoglobulin domain

  2. NM_001305157.1 → NP_001292086.1  platelet endothelial cell adhesion molecule isoform 3 precursor

    See identical proteins and their annotated locations for NP_001292086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' coding exon, which results in a frameshift, compared to variant 1. It encodes isoform 3 which has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK084527, AK169431, BE692027, BY781761
    Consensus CDS
    CCDS79069.1
    UniProtKB/Swiss-Prot
    B1ARB1, B1ARB2, Q08481, Q3TES6, Q922E0
    UniProtKB/TrEMBL
    B1ARB3
    Related
    ENSMUSP00000102408.3, ENSMUST00000106796.9
    Conserved Domains (3) summary
    smart00410
    Location:33 → 117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317 → 393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33 → 107
    Ig; Immunoglobulin domain

  3. NM_001305158.1 → NP_001292087.1  platelet endothelial cell adhesion molecule isoform 4 precursor

    See identical proteins and their annotated locations for NP_001292087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame 5' coding exon, and contains an alternate 3' coding exon which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK037551, AK084527, AK169431, BE692027, BY781761
    Consensus CDS
    CCDS79068.1
    UniProtKB/TrEMBL
    B1ARB3
    Related
    ENSMUSP00000138959.2, ENSMUST00000183610.8
    Conserved Domains (4) summary
    smart00410
    Location:33 → 117
    IG_like; Immunoglobulin like
    pfam00635
    Location:85 → 185
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam13895
    Location:216 → 292
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33 → 107
    Ig; Immunoglobulin domain

  4. NM_008816.3 → NP_032842.2  platelet endothelial cell adhesion molecule isoform 1 precursor

    See identical proteins and their annotated locations for NP_032842.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK084527, BE692027, BY781761
    Consensus CDS
    CCDS25559.1
    UniProtKB/TrEMBL
    B1ARB3
    Related
    ENSMUSP00000079664.5, ENSMUST00000080853.11
    Conserved Domains (3) summary
    smart00410
    Location:33 → 117
    IG_like; Immunoglobulin like
    pfam13895
    Location:317 → 393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33 → 107
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106545039..106606107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08481.1 GenPept UniProtKB/Swiss-Prot:Q08481

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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