Nxph1 neurexophilin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxph1provided by MGI
Official Full Name: neurexophilin 1provided by MGI
Primary source: MGI:MGI:107492
See related: Ensembl:ENSMUSG00000046178 AllianceGenome:MGI:107492
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C130005L03Rik
Summary: Enables signaling receptor binding activity. Involved in modulation of chemical synaptic transmission. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic cleft. Is expressed in brain; metanephros; and spinal cord mantle layer. Orthologous to human NXPH1 (neurexophilin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 2.9), frontal lobe adult (RPKM 2.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 4.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (8948154..9259863)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (8948614..9249619)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nxph1 plays an instructive role in synaptic short-term plasticity and the configuration with GABA receptors.
Title: Modulation of synaptic function through the α-neurexin-specific ligand neurexophilin-1.
results demonstrate the presence and function of a regulated signaling axis in hematopoiesis centered on NRXN1alpha and its modulation by DAG1 and NXPH1
Title: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
Study on the expression of NXPH1 in the developing and adult olfactory bulb
Title: Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: neurexophilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.