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Nsg2 neuron specific gene family member 2 [ Mus musculus (house mouse) ]

Gene ID: 18197, updated on 2-Nov-2024

Summary

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Official Symbol
Nsg2provided by MGI
Official Full Name
neuron specific gene family member 2provided by MGI
Primary source
MGI:MGI:1202070
See related
Ensembl:ENSMUSG00000020297 AllianceGenome:MGI:1202070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P19
Summary
Predicted to enable clathrin light chain binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in Golgi cis cisterna membrane and multivesicular body membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including axial skeleton; intestine; nasal epithelium; nervous system; and retina. Orthologous to human NSG2 (neuronal vesicle trafficking associated 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 228.8), whole brain E14.5 (RPKM 160.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Nsg2 in Genome Data Viewer
Location:
11 A4; 11 18.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (31949678..32009211)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (31999704..32059211)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930524B15 gene Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29098 Neighboring gene STARR-seq mESC enhancer starr_29099 Neighboring gene predicted gene, 35267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31899676-31899877 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31899887-31900116 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31968884-31969085 Neighboring gene STARR-seq mESC enhancer starr_29101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32006435-32006636 Neighboring gene predicted gene 12108 Neighboring gene predicted gene, 39676 Neighboring gene predicted gene, 51888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assignment of the human 8.5 H gene to chromosome 5, region 5q35. Diriong S, et al. Hum Genet, 1994 Jun. PMID 8005598
  2. Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Chander P, et al. eNeuro, 2019 Jan-Feb. PMID 30680309, Free PMC Article
  3. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Ueda T, et al. Blood, 2015 May 28. PMID 25872778, Free PMC Article
  4. A 19-kDa protein belonging to a new family is expressed in the Golgi apparatus of neural cells. Sabéran-Djoneidi D, et al. J Biol Chem, 1995 Jan 27. PMID 7829526
  5. The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo. Barford K, et al. J Comp Neurol, 2017 Jun 1. PMID 28299779, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NSG2 is found in discrete punctae restricted to the somatodendritic arbors of developing mouse and human neurons, and a significant proportion of NSG2 punctae colocalize with postsynaptic HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs) at excitatory synapses.
    Title: Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission.
  2. we show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development.
    Title: The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.
  3. Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation.
    Title: Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cis cisterna membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in multivesicular body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
neuronal vesicle trafficking-associated protein 2
Names
neuron-specific protein family member 2
protein 8.5
protein p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290680.1 → NP_001277609.1  neuronal vesicle trafficking-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001277609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK075612, BM114408, BU058771, CO040919
    Consensus CDS
    CCDS24516.1
    UniProtKB/Swiss-Prot
    P47759
    UniProtKB/TrEMBL
    Q5SS02
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 169
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  2. NM_001290681.1 → NP_001277610.1  neuronal vesicle trafficking-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001277610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK075612, AL669946, BM114408, CD352422, CO040919
    Consensus CDS
    CCDS24516.1
    UniProtKB/Swiss-Prot
    P47759
    UniProtKB/TrEMBL
    Q5SS02
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 169
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  3. NM_001347080.1 → NP_001334009.1  neuronal vesicle trafficking-associated protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' terminal exon, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK041338, DN176718
    Consensus CDS
    CCDS88140.1
    UniProtKB/TrEMBL
    Q5SS03
    Related
    ENSMUSP00000090907.4, ENSMUST00000093219.4
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 74
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  4. NM_008741.4 → NP_032767.1  neuronal vesicle trafficking-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_032767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK075612, BM114408, CO040919, DN176718
    Consensus CDS
    CCDS24516.1
    UniProtKB/Swiss-Prot
    P47759
    UniProtKB/TrEMBL
    Q5SS02
    Related
    ENSMUSP00000020537.3, ENSMUST00000020537.9
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 169
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    31949678..32009211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245647.2 → XP_030101507.1  neuronal vesicle trafficking-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P47759
    UniProtKB/TrEMBL
    Q5SS02
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 169
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  2. XM_036156412.1 → XP_036012305.1  neuronal vesicle trafficking-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    Q5SS03
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 74
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47759.1 GenPept UniProtKB/Swiss-Prot:P47759

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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